Evaluation of a Portable Haemoglobin Metre Performance in Children with Sickle Cell Disease and Implications for Healthcare in Resource-poor Settings

Olatunya, Oladele Simeon; Olu-Taiwo, Adebola; Ogundare, Ezra Olatunde; Oluwayemi, Isaac Oludare; Olaleye, Abiola O; Fadare, Joseph; Adekoya-Benson, Tolulope; Fatunla, Odunayo Adebukola; Agaja, Oyinkansola Tolulope; Omoniyi, Evenly; Oluwadiya, Kehinde Sunday

doi:10.1093/tropej/fmw015

Cited by 6 publications

(25 citation statements)

References 22 publications

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“…These observations make the POCT device ideal for use in SSA. 7,8,14,[20][21][22][23] Nothing drives home the reliability of the POCT for detecting and diagnosing HbSS among patients than its 100% agreement with the gold standard in this study. This high accuracy as found in this study, has also been previously reported regarding the performance of HemotypeSC among different study populations.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Accuracy of HemotypeSC as a Point-of-Care Testing Device for Sickle Cell Disease: Findings from a Southwestern State in Nigeria and Implications for Patient Care in Resource-Poor Settings of sub-Saharan Africa

Olatunya

Albuquerque

Fagbamigbe

et al. 2021

Global Pediatric Health

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This study aimed to determine the performance of a rapid, point-of-care testing device (HemotypeSC)™ for diagnosing sickle cell disease (SCD) relative to 2 commonly-used methods compared to DNA polymerase chain reaction (PCR) as the reference standard. The diagnostic performance of (HemotypeSC)™ in diagnosing SCD and determining various other Hb genotypes relative to high performance liquid chromatography (HPLC) and cellulose acetate Hb electrophoresis in alkaline buffer (CAE) was investigated among 156 participants aged 4 to 23 years in Ekiti, Southwest Nigeria. PCR was considered as the reference method/gold standard. The sensitivity and specificity for SS, SC, AS, AC, and AA genotypes by HemotypeSC and HPLC when compared with PCR, were each 100%. Similarly, their positive and negative predictive values were each 100%. However, sensitivity and specificity for identifying these Hb genotypes by CAE were 100, 100, 96.5, 0, 99.2%, and 99, 100, 92.9, 0, 91.7%. Also, CAE did not identify any of the 2 HbAC individuals that were correctly identified by PCR and both HemotypeSC, and HPLC, thus representing 100% HbAC misdiagnosis. In conclusion, this study shows that HemotypeSC has perfect concordance with PCR and 100% accuracy in diagnosing SCD in the population tested. Its ease of use, accuracy and other attributes make it suitable for use in sub-Saharan Africa for rapid determination of Hb genotypes.

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Section: Discussionmentioning

confidence: 99%

“…These observations make the POCT device ideal for use in SSA. 7 , 8 , 14 , 20 - 23 …”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Accuracy of HemotypeSC as a Point-of-Care Testing Device for Sickle Cell Disease: Findings from a Southwestern State in Nigeria and Implications for Patient Care in Resource-Poor Settings of sub-Saharan Africa

Olatunya

Albuquerque

Fagbamigbe

et al. 2021

Global Pediatric Health

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“…Thirteen studies (32%) reported challenges to POC(Hb)T use [13,15,19,29,31,32,47,49,50,54,55,58,60]. Overestimation of Hb concentration (n = 5) and errors in sampling and environmental factors (n = 5) were the most frequently reported challenges.…”

Section: Challengesmentioning

confidence: 99%

“…Difficulty in obtaining measurement/capillary sample in agitated children-can take longer to take measurement Rad-67 [58] HemoCue 801 [13] Aptus [49] 3 [15,19,54,58]. Specificity to detect anaemia and severe anaemia ranged from 70%-96.7% (median 84.7%, IQR: 6.1, n = 4) and 74.5%-100% (median 93.2%, IQR: 16.5, n = 7), respectively.…”

Section: Clinically Unacceptable Accuracymentioning

confidence: 99%

Use of point‐of‐care haemoglobin tests to diagnose childhood anaemia in low‐ and middle‐income countries: A systematic review

Brehm,

South,

George

2023

Tropical Med Int Health

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ObjectivesAnaemia is a major cause of mortality and transfusion in children in low‐ and middle‐income countries (LMICs); however, current diagnostics are slow, costly and frequently unavailable. Point‐of‐care haemoglobin tests (POC(Hb)Ts) could improve patient outcomes and use of resources by providing rapid and affordable results. We systematically reviewed the literature to investigate what, where and how POC(Hb)Ts are being used by health facilities in LMICs to diagnose childhood anaemia, and to explore challenges to their use.MethodsWe searched a total of nine databases and trial registries up to 10 June 2022 using the concepts: anaemia, POC(Hb)T, LMIC and clinical setting. Adults ≥21 years and literature published >15 years ago were excluded. A single reviewer conducted screening, data extraction and quality assessment (of diagnostic studies) using QUADAS‐2. Outcomes including POC(Hb)T used, location, setting, challenges and diagnostic accuracy were synthesised.ResultsOf 626 records screened, 41 studies were included. Evidence is available on the use of 15 POC(Hb)Ts in hospitals (n = 28, 68%), health centres (n = 9, 22%) and clinics/units (n = 10, 24%) across 16 LMICs. HemoCue (HemoCue AB, Ängelholm, Sweden) was the most used test (n = 31, 76%). Key challenges reported were overestimation of haemoglobin concentration, clinically unacceptable limits of agreement, errors/difficulty in sampling, environmental factors, cost, inter‐observer variability and supply of consumables. Five POC(Hb)Ts (33%) could not detect haemoglobin levels below 4.5 g/dL. Diagnostic accuracy varied, with sensitivity and specificity to detect anaemia ranging from 24.2% to 92.2% and 70% to 96.7%, respectively.ConclusionsPOC(Hb)Ts have been successfully utilised in health facilities in LMICs to diagnose childhood anaemia. However, limited evidence is available, and challenges exist that must be addressed before wider implementation. Further research is required to confirm accuracy, clinical benefits and cost‐effectiveness.

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Effect of Umbilical Cord Milking on Maternal and Neonatal Outcomes in a Tertiary Care Hospital in South India: A Randomized Control Trial

George

Isac

2021

J Obstet Gynecol India

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Evaluation of a Portable Haemoglobin Metre Performance in Children with Sickle Cell Disease and Implications for Healthcare in Resource-poor Settings

Cited by 6 publications

References 22 publications

Diagnostic Accuracy of HemotypeSC as a Point-of-Care Testing Device for Sickle Cell Disease: Findings from a Southwestern State in Nigeria and Implications for Patient Care in Resource-Poor Settings of sub-Saharan Africa

Diagnostic Accuracy of HemotypeSC as a Point-of-Care Testing Device for Sickle Cell Disease: Findings from a Southwestern State in Nigeria and Implications for Patient Care in Resource-Poor Settings of sub-Saharan Africa

Use of point‐of‐care haemoglobin tests to diagnose childhood anaemia in low‐ and middle‐income countries: A systematic review

Effect of Umbilical Cord Milking on Maternal and Neonatal Outcomes in a Tertiary Care Hospital in South India: A Randomized Control Trial

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