Evaluation of Acyclovir Cream and Gel Formulations for Transdermal Iontophoretic Delivery

Siddoju, Srujana; Sachdeva, Vishal; Friden, Phillip M.; Banga, Ajay K.

doi:10.4155/tde.11.152

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Showed the most prolonged local analgesic effects and enhanced local anesthetic action (Kang & Shin, 2012). Acyclovir Showed enhanced iontophoretic transdermal delivery of acyclovir (ACV), a model hydrophilic smalldrug molecule, across hairless rat skin on Franz diffusion cells (Siddoju et al, 2012).…”

Section: Vancomycinmentioning

confidence: 99%

Comprehensive review on additives of topical dosage forms for drug delivery

2014

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Skin is the largest organ of the human body and plays the most important role in protecting against pathogen and foreign matter. Three important modes such as topical, regional and transdermal are widely used for delivery of various dosage forms. Among these modes, the topical dosage forms are preferred because it provides local therapeutic activity when applied to the skin or mucous membranes. Additives or pharmaceutical excipients (non-drug component of dosage form) are used as inactive ingredients in dosage form or tools for structuring dosage forms. The main use of topical dosage form additives are controling the extent of absorption, maintaining the viscosity, improving the stability as well as organoleptic property and increasing the bulk of the formulation. The overall goal of this article is to provide the clinician with information related to the topical dosage form additives and their current major applications against various diseases.

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Section: Vancomycinmentioning

confidence: 99%

Comprehensive review on additives of topical dosage forms for drug delivery

2014

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“…Rashes or other serious side effects can occur when a more active ingredient penetrates into the skin [2]. Various controlled drug-delivery systems, such as microcapsules, microspheres, nanoemulsion, liposomes and niosomes, have been investigated in order to maximize the duration of active ingredients being present either on the epidermis or within skin layers, while minimizing their transdermal penetration into the body [3][4][5][6]. However, the release rate of active drugs from microcapsules cannot be controlled once the capsule wall is ruptured.…”

mentioning

confidence: 99%

Investigation of Ethyl Cellulose Microsponge Gel for Topical Delivery of Eberconazole Nitrate for Fungal Therapy

et al. 2014

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“…37 A number of studies have been reported in the literature where VDCs have been employed for testing the drug release and/or permeation from acyclovir topical formulations. [38][39][40][41][42][43] Considering the advantages of immersion cells, we decided to study the IVRT of acyclovir cream formulations by using immersion cells. We initially studied the effect of test variables such as type of membrane, stirring speed, media temperature, media volume, and cell size on the acyclovir release from its marketed cream formulation.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Release Testing of Acyclovir Topical Formulations Using Immersion Cells

Kulkarni

Potdar

Date

et al. 2021

ASSAY and Drug Development Technologies

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The objective of the study was to reinforce the applicability of the immersion cells for the in vitro release testing (IVRT) of topical formulations by using marketed acyclovir 5% cream formulation (Cream 1) as a model. The method employing the immersion cells was optimized by studying the effect of variables, such as membrane type, media temperature and volume, agitation speed, and cell size, on acyclovir release from the formulation. The in-house formulation similar to the qualitative and quantitative composition of Cream 1 and the other trial formulations with variable compositions were prepared and studied by using the immersion cells. Various other brands of acyclovir topical formulations available in the Indian market were also subjected to IVRT by using the optimized method. An increase in the media temperature from 32°C to 37°C and the stirring speed from 50 to 100 to 150 rpm led to an increase in the drug release. As the immersion cell size increased (0.5, 2 and 4 cm 2 surface area), the release rate also increased. Nitrocellulose membrane showed the highest drug release and Fluoropore Ô the least. The optimized IVRT method could establish the differences in the drug release rates among the formulations with the altered compositions. The method could also prove its discriminatory potential for various marketed formulations. The immersion cell method could serve as a simpler, facile, and reliable aid during product development and also as a quality control tool in assessing stability, aging, and batch-tobatch uniformity of semisolid formulations.

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Evaluation of Acyclovir Cream and Gel Formulations for Transdermal Iontophoretic Delivery

Cited by 6 publications

References 23 publications

Comprehensive review on additives of topical dosage forms for drug delivery

Comprehensive review on additives of topical dosage forms for drug delivery

Investigation of Ethyl Cellulose Microsponge Gel for Topical Delivery of Eberconazole Nitrate for Fungal Therapy

In Vitro Release Testing of Acyclovir Topical Formulations Using Immersion Cells

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