Evaluation of <i>Abelmoschus moschatus</i> seed extract in psychiatric and neurological disorders

Abstract

In the world, 450 million people suffered from mental disorders also the particular global burden will be increased from 12.3 to 15% by 2020. 1 Depression are extremely dramatic and debilitating multifacetic disorders, which ranked as the fourth leading cause of mortality, disability and life threatening disease, characterized by a downcast mood, loss of pleasure, negative thoughts, disturbed sleep or appetite, low energy and suicidal ideations. 2 Several antidepressant therapies aimed for enhance the neurotransmitter level and normalize the transmission. 3 Although majority of commercially available anti-depressant drugs have proven to be effective, but they caused adverse side-effects such as tiredness, blurred vision, weight gain, nausea, dry mouth, agitation fatigue and sexual dysfunction. 4 Anxiety is a high prevalent physiological state characterized by sympathetic hyperactivity, psychomotor tension, and vigilance syndrome. 5 Benzodiazepines, diazepam are used to treat anxiety disorders and causes adverse side-effects such as amnesia, sedation, changes in body weight and physical dependence. 6 Commercial drug benzodiazepines for insomnia have adverse effect viz., hangover, addiction and subsequent drug resistance. Even though, zolpidem, zopiclone and zaleplon are non-benzodiazepine, which is most recently permitted for the short-term executive of insomnia, also have side-effects such as headache, anxiety and wooziness. 7 Epilepsy associated with high rhythmic high frequency of impulses discharges by a group of neurons in the central nervous system (CNS). Researchers focused

Seed Extract of Abelmoschus Moschatus Medik Reverses Naf-Induced Behavioral Changes Through Neurodegeneration and Oxidative Stress in Brain of Rat

“…A. moschatus (L) Medik, family Malvaceae, is an aromatic and medicinal plant popularly known as mushkdana or kasturi bhendi or ornamental okra. It is a prostate herb widely cultivated for its seeds and essential oil along the tropical regions of Asia, Africa, and South America [18]. Phytochemical studies of the seed extract showed the presence of flavonoids, phenols, saponins, carbohydrates, terpenoids, myricetin,…”

A Review on CNS Effects of Abelmoschus moschatus

“…Abelmoschus moschatus have several pharmacological 20 22 properties such as anti diabetic , Insulin sensitizing , antimicrobial, antioxidant, anti proliferative, free radical 21 23 24 scavenging , hepatoprotective , anti lithiatic , anti 26 27 28 diuretic , antibacterial , anti fungal , memory 25 strenthing and also has an effect on some psychiatric 29 and neurological conditions . In this review article, we have attempted to delineate the CNS effects of AM extract.…”

Organogenesis of Abelmoschus moschatus Medik. Using Aseptic Seedling Explants

“…It also shows protective mechanism in respiratory troubles and asthma antispasmodic itch [12]. Sheik et al [13] reported A. moschatus is an alternative source for central nervous system (CNS) drug development. Abelmoschus moschatus is usually propagated from its seeds but seeds lose their germination viability soon after harvesting.…”