Evaluation of analgesic and anti-inflammatory activity of Bridelia retusa (Spreng) bark

Tatiya, Anil U.; Saluja, A. K.; Kalaskar, Mohan G.; Surana, Sanjay J.; Patil, Prakash H.

doi:10.1016/j.jtcme.2016.12.009

Cited by 58 publications

(31 citation statements)

References 45 publications

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“…Several species of this genus have been used in traditional medicinal systems for the management of multiple diseases, including diabetes, urinary stones, lumbago, rheumatism, venereal diseases, bronchitis, gastrointestinal problems, cardiac pain, infertility, epilepsy, and diarrhoea, among others [9]. Keeping this in view, the biological efficacy of several Bridelia species has been claimed in several research pieces [10][11][12][13][14][15]. In earlier studies, the chemical profiles of the members of the Bridelia genus have been reported.…”

Section: Introductionmentioning

confidence: 99%

Bridelia speciosa Müll.Arg. Stem bark Extracts as a Potential Biomedicine: From Tropical Western Africa to the Pharmacy Shelf

et al. 2020

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Bridelia species have been used in traditional African medicine for the management of diverse human ailments. In the current work, the detailed phytochemical profiles of the extracts of the stem bark of B. speciosa were evaluated and the antioxidant and enzyme inhibitory properties of the extracts were assessed. The anti-bacterial and anti-mycotic effects of the extracts were evaluated against selected pathogen strains. Additionally, the anti-proliferative effects were studied on the liver cancer HepG2 cell line. Finally, the putative protective effects were assessed on isolated rat liver that was challenged with lipopolysaccharide (LPS). The results revealed the presence of 36 compounds in the ethyl acetate extract, 44 in the methanol extract, and 38 in the water extract. Overall, the methanol extract showed the highest antioxidant activity, particularly in LPS-stimulated rat liver. Additionally, this extract exerted the highest antimycotic effect on C. albicans, whereas the water extract showed a promising anti-proliferative effect on liver cancer HepG2 cells. The methanol extract was also the most active as enzyme inhibitor, against acetylcholinesterase and butyrylcholinesterase. The current study appraises the antioxidant and enzyme inhibition properties of B. speciosa methanol extract and showed that this specie could be a promising source of biologically active phytochemicals, with potential health uses. Supplementary Materials: The following are available online at http://www.mdpi.com/2076-3921/9/2/128/s1. Supplementary Materials and Methods; CFF-strains. Author Contributions: Conceptualization, C.F. and G.Z.; methodology, G.O.; L.M.; software, L.M.; validation,: C.F.; G.Z.; L.M.; G.O.; formal analysis, C.F.; G.Z.; investigation, K.I.S.; K.B.; S.L.; L.R.; A.C. (Annalisa Chiavaroli); S.V.; P.A.; V.H.; S.C.; R.V.; L.D.L.; A.C. (Alessandro Cama); M.C.N.P.-A.; Z.C.; J.J.; M.F.M.; resources, C.F.; G.O.; L.M.; data curation, C.F.; G.Z.; writing-original draft preparation, M.F.M.; writing-review and editing, C.F., G.Z.; G.O.; L.M.; visualization, L.B.; supervision, L.B.; project administration, C.F.; L.M.; G.O.; G.Z.; funding acquisition, C.F.; G.O.; L.M. All authors have read and agreed to the published version of the manuscript.

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Section: Introductionmentioning

confidence: 99%

Bridelia speciosa Müll.Arg. Stem bark Extracts as a Potential Biomedicine: From Tropical Western Africa to the Pharmacy Shelf

et al. 2020

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“…Lupeol acetate identified in Cariniana domestica (Mart.) Miers family Lecythidaceae and Bride-lia retusa (Spreng) family Euphorbiaceae presented anti-inflammatory effect in skin inflammation and in adjuvant-induced arthritis models [28,29]. One of the anti-inflammatory mechanisms of lupeol acetate in arthritis models was the suppression of pro-inflammatory cytokines expression and inhibition of osteoclastogenesis [30].…”

Section: Discussionmentioning

confidence: 99%

Supercritical Extracts from Arctium lappa as a Potential Inhibitor for the Activation of Complement System

Fontana

Bavia

Bovo

et al. 2019

PMIO

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Arctium lappa is a perennial species of the Asteraceae family originally from Europe and Asia. Considered a weed species in the southern region of Brazil, it is popularly used as a natural anti-inflammatory. The complement system is an important component of the innate immune response. However, its exacerbated activation can lead to harmful conditions like autoimmune and inflammatory disorders. Plants that inhibit the activation of complement can be a promising tool in the treatment of inflammatory diseases. Here, we evaluated the effect of A. lappa leaves extracts on the activation of the classical and alternative pathways of complement system. Two extracts were obtained under supercritical conditions using scCO2 with ethanol as cosolvent, at 313.15K, 15 MPa (E1) and 25 MPa (E2). Classical and alternative activation were evaluated using complement fixation test. Different concentrations of A. lappa extracts E1 and E2 showed an inhibitory effect on both complement pathways, and heparin was used as control. The IC50 of E1, E2, and heparin were 28.26, 20.12 and 92.54 µg/mL for classical and 26.12, 27.70, 27.78 µg/mL for the alternative pathway. Results demonstrate that A. lappa is a promising complementary treatment for diseases associated with complement activation.

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“…By intravenously injecting Evans blue, we could monitor the vascular permeability to the site of inflammation [42]. Acetic acid causes peritoneal inflammation and induces an increase in PGE 2 and PGF 2a in the peritoneal fluid [43]. This capillary permeability assay is a typical model for acute phase of inflammation, where mediators of inflammation released following stimulation lead to the dilation of both arterioles and venules and increase capillary permeability [24].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect of <i>o</i>-Vanillic Acid on Lipopolysaccharide-Stimulated Macrophages and Inflammation Models

Lee¹,

Lee²,

Shin³

et al. 2018

JFNR

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Inflammation is an important biological reaction in the body in response to external stimuli. Excessive inflammation causes various inflammatory disorders such as allergic hypersensitivity, autoimmune disease, rheumatoid arthritis, and cancer. Macrophages play a major role in the inflammatory response by producing inflammatory mediators such as nitric oxide, prostaglandin E 2 , and pro-inflammatory cytokines. Natural products are often a source of bioactive compounds, which have great potential as novel therapeutic agents. Amomum xanthoides extract has been shown to possess various pharmacological activities including anti-inflammatory activity. This study evaluated the anti-inflammatory potential of o-vanillic acid (o-VA), a major compound in A. xanthoides, using lipopolysaccharide (LPS)-induced macrophages and in vivo animal models. o-VA decreased, in a concentration-dependent manner, the LPS-induced gene expression and production of inflammatory mediators, such as inducible nitric oxidase/cyclooxygenase-2 and pro-inflammatory cytokines, by reducing the nuclear factor-κB activation. In addition, o-VA dose-dependently ameliorated acetic acid-induced vascular permeability and zymosan-induced leukocyte migration. Thus, we suggest that o-VA can be used as a pharmacological agent or food supplement in the treatment of inflammatory conditions.

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Evaluation of analgesic and anti-inflammatory activity of Bridelia retusa (Spreng) bark

Cited by 58 publications

References 45 publications

Bridelia speciosa Müll.Arg. Stem bark Extracts as a Potential Biomedicine: From Tropical Western Africa to the Pharmacy Shelf

Bridelia speciosa Müll.Arg. Stem bark Extracts as a Potential Biomedicine: From Tropical Western Africa to the Pharmacy Shelf

Supercritical Extracts from Arctium lappa as a Potential Inhibitor for the Activation of Complement System

Anti-Inflammatory Effect of <i>o</i>-Vanillic Acid on Lipopolysaccharide-Stimulated Macrophages and Inflammation Models

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