Evaluation of Anti-Inflammatory Activity of Aqueous Extract of Leaves of Solanum Melongena Linn . in Experimental Animals

Umamageswari, M S

doi:10.7860/jcdr/2015/10777.5428

Cited by 9 publications

(8 citation statements)

References 9 publications

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“…In comparison to the control group, we noticed that the normal saline-treated group had a significant paw thickness increase which peaked at 3 hours after carrageenan injection. This finding was also described by Umamageswari and Maniyar [27]. Indeed, carrageenan induced an acute inflammatory reaction typically characterized by vasodilation and tissue swelling.…”

Section: Discussionsupporting

confidence: 80%

The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers

Bardaa

Turki

Khedir

et al. 2020

BioMed Research International

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Medicinal plants have been used as a source of effective and safe alternative therapeutic agents for various ailments including inflammation. In fact, the aim of this study is to assess the topical anti-inflammatory and antioxidative potential effects of Cucurbita pepo (pumpkin), Linum usitatissimum (linseed), and Opuntia ficus indica (prickly pear) oils on acute inflammation using carrageenan-induced paw edema model. The study was conducted on 36 rats splitted in 6 groups: a normal control group and 5 carrageenan-treated groups (1%), each treated with either a normal saline, the reference drug (“Inflocine®” 2 mg/paw), pumpkin, linseed, or prickly pear oils (25 μl/paw). The response to these treatments was mainly assessed by the measuring of edema paw size, hematological and biochemical analysis, oxidative stress testing, and histological study. All the studied seed oils especially prickly pear oil proved to be efficient in treating acute inflammation. The oil-treated groups revealed a significant (p<0.05) decrease in the clinical signs of inflammation, hematological parameters (white blood cells and platelets), concentrations of CRP and fibrinogen, and congestion compared to the normal saline-treated group. The results also showed that the tested oils, endowed with a radical scavenging ability, could significantly increase the activities of SOD, CAT, and GPx in carrageenan-treated skin by reducing the lipid peroxidation and protein oxidation (TBARS, AOPP). The anti-inflammatory effect of the tested oils was closely related to both their antioxidant properties as well as their bioactive compounds (polyunsaturated fatty acids, vitamin E, and phytosterols). For the first time, the findings of the current study highlight the “in vivo” anti-inflammatory property of pumpkin, linseed, and prickly pear oils on carrageenan-induced acute inflammation by regulating inflammatory mediators and oxidative stress markers.

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Section: Discussionsupporting

confidence: 80%

The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers

Bardaa

Turki

Khedir

et al. 2020

BioMed Research International

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“…Umamageswari and Maniyar [ 22 ] reported the presence of saponins in the aqueous extract of eggplant leaves ( S. melongena L.), which differs from our study since saponins were only found in the aqueous extract of the stem and fruit, and the methanolic extract of the fruit, perhaps due to the process used to obtain the extract. On the other hand, these same authors reported the presence of tannins and flavonoids, similar to our study.…”

Section: Resultscontrasting

confidence: 99%

“…For this reason, eggplant is one of the top ten vegetables with high oxygen radical absorbance capacity [ 16 , 18 , 19 ]. In some eggplant studies, the antioxidant [ 20 ], antidiabetics [ 21 ], anti-inflammatory [ 22 , 23 ], antiproliferative [ 24 ], analgesic [ 25 ], antimicrobial [ 26 , 27 ], and anticancer properties [ 28 , 29 , 30 ] are mainly related to its secondary metabolite content. A group of researchers has developed a product from eggplant peel (generally considered waste), showing an anticancer effect on skin cancer cells [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Analysis of Phytochemical Compounds from Agricultural Residues of Eggplant (Solanum melongena L.)

et al. 2022

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The eggplant is a fruit rich in natural products and produced worldwide. However, its cultivation generates a large amount of scarcely used agricultural residues with poor chemical characterization. This study aimed to identify and quantify the metabolome and determine the composition of select phytochemicals and the overall antioxidant capacity of various anatomical parts of the plant. The plant’s root, leaf, stem, and fruit were analyzed by quantitative mass spectrometry-based untargeted metabolomics and chemoinformatics, and phytochemicals were quantified by spectrophotometric analysis. Moreover, we determined the total antioxidant capacity of the distinct plant parts to infer a possible biological effect of the plant’s metabolites. Various secondary metabolites were identified as terpenes, phenolic compounds, alkaloids, and saponins, distributed throughout the plant. The leaf and fruit presented the highest concentration of phenolic compounds, flavonoids, anthocyanins, and alkaloids, accompanied by the highest antioxidant capacity. Although the stem and root showed the lowest abundance of secondary metabolites, they provided around 20% of such compounds compared with the leaf and fruit. Overall, our study improved the understanding of the eggplant metabolome and concluded that the plant is rich in secondary metabolites, some with antioxidant properties, and shows potential nutraceutical and biopharmaceutical applications.

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“…After 1 hr all the animals received 10 ml/kg of 0.7% v/v acetic acid injection intraperitoneally. The writhing episodes were recorded for 30 minutes; stretching movements consisting of arching of the back, elongation of body and extension of hind limbs were counted (Umamageswari and Yasmeen, 2015).…”

Section: Acetic Acid Induced Writhingmentioning

confidence: 99%

Synergistic effect of Lemon and Ginger juice for analgesic activity on Swiss albino mice

Bhandare¹,

Kotade²

2018

Asian J Pharm Pharmacol

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Objective: The present study was carried out to investigate the synergestic effect of and juice for central lemon ginger and peripheral analgesic activity on experimental animals using Acetic acid induce writhing, Hot plate and Tail immersion methods. The central analgesic activity was measured by Hot plate and Tail Material and methods: immersion methods in Swiss albino mice and peripheral analgesic activity was measured by acetic acid induced writhing in Swiss albino mice. Aspirin was used as the standard drug in the dose of 100 mg/kg. The juice and lemon ginger juice was administered at 0.8 ml per animal. Phytochemical analysis showed the presence of flavonoids, alkaloids, glycosides, saponins, tannins, sterols, carbohydrates, and resins. All the doses showed significant Result: central and peripheral analgesic activity i.e (p<0.05), which is comparable to that of the control and standard drug aspirin. The test and standard drugs significantly (p<0.05) reduced the number of abdominal constriction and stretching of hind limb induce by the injection of acetic acid in a dose dependent manner. The Hot plate and Tail immersion test useful in the elucidating centrally mediated antinociceptive responses, which focused mainly on changes above the spinal cord level. All the test and standard drugs significantly (p<0.05) reduced the pain as compare to the control group. Conclusion: The results of pharmacological tests performed in the present studies suggest that the and lemon ginger juice in combination gives Synergestic effect for analgesic activity.

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Evaluation of Anti-Inflammatory Activity of Aqueous Extract of Leaves of Solanum Melongena Linn . in Experimental Animals

Cited by 9 publications

References 9 publications

The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers

The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers

Metabolomic Analysis of Phytochemical Compounds from Agricultural Residues of Eggplant (Solanum melongena L.)

Synergistic effect of Lemon and Ginger juice for analgesic activity on Swiss albino mice

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