Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: Possible involvement of NOS inhibition

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats

“…Further, areca nut has antioxidant, anti-inflammatory, and anti-osteoporotic properties [21][22][23]. Overall, the results of the present study are consistent with those of earlier works, in which extracts and compounds isolated from A. catechu were found to have an analgesic effect in mice and rats [6,7] and antimigraine activity in rats [8,9]. Furthermore, the current study demonstrated the antiallodynic effects of intrathecal areca nut in spinal nerve-ligated and cisplatin-induced NP states.…”

“…tivity in hot plate, formalin, and acetic acid-induced pain tests in mice and rats [6,7]. Also, it has been reported that areca nut had anti-migraine effect in animal models [8,9], but there have been no reports on the effect of areca nut on NP. Furthermore, the mechanism(s) underlying the analgesic action of areca nut have not been determined.…”

Simo decoction promotes contraction of antral circular smooth muscle mainly via muscarinic M3 receptor

“…Activation of b-adrenergic receptor will transmit an inhibitory message to gastric smooth muscle (Mandrek and Kreis, 1992), which suggests that SMD may promote contractions through inhibition of b-adrenergic receptor. Exogenous NO also decreases the SMD-induced contractions, it has been clarified that herb can suppress expression of nitric oxide synthase (Bhandare et al, 2011), which indicates that inhibition of NO releasing may be a way involved in SMD-induced contractions. Even though study shows that excitation of nicotinic receptor will abolish spontaneous contractions of colonic strips (Auli et al, 2008), another study suggests that activation of nicotinic receptor can increase contractile response of rabbit gastric fundus through facilitating release of neurotransmitters (Ilhan et al, 2007), and our results also indicate that the excitation of nicotinic receptor is a way of SMD promoting contractions of antral strips.…”

Migraine: Molecular Basis and Herbal Medicine

“…It is noted that mitogenactivated protein kinase signal transduction participated in initiation and stimulation of inflammatory responses and pain feeling. It has been suggested that high level of borocyanides in Arace catechu as well as inhibitory influence on inducible nitric oxide synthase activity can be involved in its underlying mechanism in anti-migraine properties (Bhandare et al, 2011).…”