Evaluation of anticonvulsant and neuroprotective effects of camel milk in strychnine-induced seizure model

Khatoon, Humera; Najam, Rahila; Mirza, Talat; Sikandar, Bushra; Ishaq, Humera; Anser, Humera

doi:10.1016/s2222-1808(15)60937-9

Cited by 14 publications

(8 citation statements)

References 14 publications

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“…Despite the positive trend of changes in the convulsive activity of Allapinin and N-DAL in the studied doses, this did not have a statistically significant effect on the latency period of clonic seizures associated with isoniazid and the survival of animals. This can be explained by the involvement of other nervous structures in epileptogenesis, unlike other models of seizures caused by GABA receptor blockers [27]. Based on the results obtained, allapinin and N-DAL showed higher activity compared to the control group and carbamazepine of low activity.…”

Section: Results and Their Discussionmentioning

confidence: 84%

Evaluation of Anticonvulsant Activity of Allapinine and N-Deacetylappaconitine in Experimental Animals.

Sanoev¹,

Khamroev²,

Abdinazarov³

et al. 2021

JHTD

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The present article presents a research paper on the evaluation of anticonvulsant activity of allapinine and N-debacetylappaconitine with high antiarrhythmic activity caused at different doses and with different analyzers. The results of the conducted studies showed that allapinine and N-debacetylappaconitine are not inferior and even slightly superior to carbamazepine in anticonvulsant activity. In this regard, based on the conducted studies, it can be concluded that allapinin affects not only cardiomyocytes, but also ion exchange in nerve cells.

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Section: Results and Their Discussionmentioning

confidence: 84%

Evaluation of Anticonvulsant Activity of Allapinine and N-Deacetylappaconitine in Experimental Animals.

Sanoev¹,

Khamroev²,

Abdinazarov³

et al. 2021

JHTD

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“…In this study, treatment with CM (2 ml/rat/day) increased IL-10, improved sensorimotor function, impaired memory and exploration, and increased dopamine (DOPA) and acetylcholinesterase (AChE) levels ( 64 ). By protecting areas of the brain against FNP-induced damage, CM enhanced sensorimotor function ( 80 ). The presence of high amounts of copper, zinc, magnesium, vitamins E and C ( 81 ) has led to the beneficial role of CM in maintaining sensory-motor balance ( 82 , 83 ).…”

Section: Resultsmentioning

confidence: 99%

The Antioxidant, Anti-Inflammatory and Immunomodulatory Effects of Camel Milk

et al. 2022

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Camel milk (CM) has been found to have several health benefits, including antiviral, antibacterial, anti-tumor, anti-fungal, antioxidant, hypoglycaemic and anti-cancer activities. In addition, CM can counter signs of aging and may be a useful naturopathic treatment for autoimmune diseases. The composition of CM varies with geographic origin, feeding conditions, seasonal and physiological changes, genetics and camel health status. In the present review, we collate the diverse scientific literature studying antioxidant, anti-inflammatory and immunomodulatory effects of CM and its bioactive compounds. The databases Scopus, PubMed, and Web of Science were searched until the end of September 2021 using the keywords: camel milk, antioxidant, anti-inflammatory, immunomodulatory. The anti-inflammatory mechanism of CM in various inflammatory disorders was consistently reported to be through modulating inflammatory cells and mediators. The common anti-inflammatory bioactive components of CM seem to be lactoferrin. The antioxidant effects of α-lactalbumin, β-caseins and vitamin C of CM work by reducing or inhibiting the production of reactive oxygen species (ROS), hydroxyl radicals, nitric oxide (NO), superoxide anions and peroxyl radicals, likely alleviating oxidative stress. Higher levels of protective proteins such as lysozyme, IgG and secretory IgA compared to cow’s milk, and insulin-like protein activity of CM on ß cells appear to be responsible for the immunomodulatory properties of CM. The evidence indicates that CM and its bioactive components has the potential to be a therapeutic value for diseases that are caused by inflammation, oxidative stress and/or immune-dysregulation.

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“…The primary search yielded 21 458 publications (PubMed, n = 4778; Scopus, n = 16 680). Only 50 studies met all the inclusion criteria and were included in the current systematic review 9–58 (Figure 1). One study was identified through the scanning of the reference lists of other reviews 41 …”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐two articles were animal/in vitro studies of the relationship between non‐alcoholic drinks and epilepsy/seizures (Table 3). 37–58 One study showed that the inhibition potency of CYP3A by pomegranate juice was similar to that of grapefruit juice and pomegranate juice altered the carbamazepine pharmacokinetics in rats 41 . Lime juice may also increase the bioavailability of carbamazepine 53 .…”

Section: Resultsmentioning

confidence: 99%

Caffeinated drinks, fruit juices, and epilepsy: A systematic review

Asadi‐Pooya

Zeraatpisheh

Rostaminejad

et al. 2021

Acta Neuro Scandinavica

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The aim of this systematic review was to provide the required information regarding different aspects of the relationship between epilepsy/antiseizure medications and non‐alcoholic drinks. The recommendations of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement were followed. MEDLINE and Scopus from the inception until 7 August 2021 were systematically searched. These key words were used: “epilepsy” OR “seizure” OR “antiepileptic” OR “antiseizure” OR “anticonvulsant” AND “coffee” OR “tea” OR “soda” OR “juice” OR “drink” OR “cola” OR “diet” (35 key word combinations). The primary search yielded 21 458 publications (PubMed, n = 4778; Scopus, n = 16 680). Only 50 studies met all the inclusion criteria and were included in the current systematic review. In total, 17 articles investigated various non‐alcoholic drinks in human studies, 11 studies were case reports/series, and 22 articles were animal/in vitro studies. None of the studies provided a class 1 of evidence. There is limited evidence suggesting that certain drinks (eg, caffeinated energy drinks) might trigger seizures. Patients with epilepsy should avoid excessive consumption of certain fruit juices (eg, grapefruit, lime, pomegranate, kinnow, and star fruit) and caffeinated drinks. However, daily coffee and tea intake can be part of a healthy balanced diet, and their consumption does not need to be stopped in patients with epilepsy. Coffee/tea consumption is not harmful if consumed at levels of 200 mg (caffeine) in one sitting (about 2½ cups of coffee) or 400 mg daily (about five cups of coffee).

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Evaluation of anticonvulsant and neuroprotective effects of camel milk in strychnine-induced seizure model

Cited by 14 publications

References 14 publications

Evaluation of Anticonvulsant Activity of Allapinine and N-Deacetylappaconitine in Experimental Animals.

Evaluation of Anticonvulsant Activity of Allapinine and N-Deacetylappaconitine in Experimental Animals.

The Antioxidant, Anti-Inflammatory and Immunomodulatory Effects of Camel Milk

Caffeinated drinks, fruit juices, and epilepsy: A systematic review

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