Evaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazil

Abstract

RESULTS:Our results showed many secretory canals in resin fruit and leaf; identifying lipids, starch, lignin and phenolic compounds.The leaf extract induced genotoxicity and apoptosis in B16-F10 cells, since the fragmentation of DNA in the comet assay. The ethanolic extract of mangosteen obtained in the resin, leaf and fruit showed antimicrobial activity against Staphylococcus aureus and Escherichia coli with a MIC at 0.1 mg/mL. CONCLUSION:In conclusion, we have demonstrated both antimicrobial and antitumor activity of ethanol extract of mangosteen emphasizing its therapeutic potential in infectious diseases and in cancer, such as melanoma.

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

“…Another study by Kaur and co-workers showed that eugenol has protective activity against cutaneous chemical carcinogenesis [ 170 ]. Examples of plant extracts containing phenolic compounds with anti-apoptotic properties are the extracts from Garcinia mangostana L. (mangosteen) [ 174 ], propolis [ 175 , 176 , 177 , 178 , 179 ], and Phyllanthus [ 180 , 181 , 182 , 183 , 184 , 185 ] (it also has the ability to induce cell necrosis [ 186 ]).…”

In vitro genotoxicity assessment and 28-day repeated dose oral toxicity study of steady-calcium formula in rats

“…The test substance SCF contained five major ingredients possessed the potential with joint care. Despite the safety assessment of hydrolyzed chicken sternal cartilage extract, calcium citrate, mangosteen extract, turmeric extract and soybean extract by themselves have been investigated [30] , [31] , [32] , [33] , the genotoxicity and 28-day oral toxicity of SCF containing them have not been verified. However, the uncertain cross-reactivity among these included ingredients cannot be excluded.…”

“…For instance, soy isoflavones by themselves had no effects on the induction of bone marrow chromosomal aberration and micronuclei in vivo , but could antagonize the benzo[a]pyrene-induced genotoxicity [31] . The leaf ethanoic extracts of mangosteen have been found to induce genotoxicity and apoptosis in B16-F10 melanoma cells [30] . In contrast, our genotoxicity results suggest that the mixture of these ingredients, including the leaf ethanoic extracts of mangosteen in SCF does not induce genotoxicity.…”

Antifungal and Antibacterial Activities of Juice and Ethanolic Extracts of Garcinia Mangostana L. Leaves

“…G. mangostana leaves contain polyphenolic major role in the prevention of various diseases [8]. Juice of G. mangostana contains polyphenolic compound such as flavonoid and tannin [9].…”

“…The leaves of G. mangostana are proven to have high phenolic compounds and have the potential as antibacterial and antitumor activity [7]. Juice of leaves of G. mangostana was shown to have free radical scavenging activity against α,α-diphenylβ-picrylhydrazyl (DPPH) radicals with IC 50 19 ppm [8]. The results of the previous research show the great potential as of G. mangostana.…”