Evaluation of Antioxidant Activity, Total Phenolic and Flavonoid Contents of Entada africana Guill. et Perr. (Mimosaceae) Organ Extracts

Tibiri, André; Sawadogo, Richard W.; Ouédraogo, Noufou; Banzouzi, J.T.; Guissou, Innocent Pierre; ., G.O. Nacoulma

doi:10.3923/rjmsci.2010.81.87

Cited by 31 publications

(23 citation statements)

References 32 publications

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“…Entada africana is a West African medicinal plant that is quite useful in the treatment of many ailments and diseases such as fever, diabetes, diarrhea, hypertension, arrow poison and as tonic (Bako et al, 2005;Tibiri et al, 2010). The leaves, stem bark, roots, seeds and its gum resins are used in the management of several ailments in traditional medicine in different regions of West Africa such as Mali, Niger, Cameroon and Nigeria.…”

Section: Introductionmentioning

confidence: 99%

“…Due to widespread use, the plant is now considered to be an endangered species (Banzouzi et al, 2007). Despite the existence of several reports on biological studies on the crude extracts of E. africana such as antileishmanial, antibacterial, antiinflammatory, antioxidant and wound healing properties (Tibiri et al, 2010;Mbatchou et al, 2011;Njayou et al, 2013;Marthe et al, 2014;Kwaji et al, 2017), only few reports exists on isolation of bioactive compounds such as the acidic wound healing polysaccharides (Diallo et al, 2001) and the antiproliferative triterpene saponins (Cioffi et al, 2006) from the root extracts of Entada africana. Therefore, this calls for further investigation of the bioactive constituents of Entada africana in order to understand more about its immense healing potential.…”

Section: Introductionmentioning

confidence: 99%

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Isolation, characterization and biological properties of betulin from Entada africana Guill. and Perr. (Mimosaceae).

Kwaji¹,

Adamu²,

Chindo³

et al. 2018

jaar

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The present study is aimed at the isolation, characterization and evaluation of some biological properties of betulin from Entada africana stem bark extract. A dichloromethane soluble portion of the stem bark methanol/acetone (1:1 v/v) extract was subjected to gradient elution using ethyl acetate in hexane (5 -30 %) on an open column. A pure compound was obtained with Rf = 0.61 in hexane/ethyl acetate (8:2 v/v) after repeated washing and recrystallization from methanol and coded Enac1. The pure compound was analyzed using IR, 1 H & 13 C NMR and GC-MS. Clinical isolates of Escherichia coli, Klebsiella pneumoniae, Salmonella typhi and Staphylococcus aureus were used to assess the antibacterial activity of the pure compound while its preliminary Cytotoxicity was evaluated using brine shrimp nauplii. Based on the spectroscopic data obtained and in comparison with literature, the isolated compound was identified as betulin. The minimum inhibitory concentration (MIC) of betulin ranged between 62.50 -250.00 µg/mL for all the four bacterial isolates in the study while its fifty percent lethal concentration (LC50) was 10.00 µg/mL. Significant Cytotoxicity with moderate antibacterial activity was observed. The study therefore justifies the existence of bioactive compounds in the stem bark of Entada africana and its use in traditional medicine.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isolation, characterization and biological properties of betulin from Entada africana Guill. and Perr. (Mimosaceae).

Kwaji¹,

Adamu²,

Chindo³

et al. 2018

jaar

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“…The presence in the totum was remarkable compared to the ethyl acetate extract. However, the ethyl acetate extract is a majority antioxidant compounds with better reducing capacity (Tibiri et al, 2010). The anti-oxidant activity would be increased by less polar and non-polar substances (Jagadeesan et al, 2011;Tiwari et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-hyperglycaemic activity of <i>Euphorbia hirta</i> L. on Wistar rats

Fofie¹,

Sanogo²,

Diarra³

et al. 2014

Int. J. Bio. Chem. Sci

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The objective of this study was to investigate the antioxidant capacity and anti-hyperglycemic activity of aqueous macerate extracts of Euphorbia hirta L., in the treatment of hypertension associated with diabetes. The research focused on the aqueous maceration of the aerial part or totum. The search and evaluation of the antioxidant activity was done according to the method of Blois based on the reduction of 2,2-diphenyl-1-picrylhydrazyl (DPPH). The search for antihyperglycaemic activity was performed on rats having received a glucose overdose. This activity was compared to those of glyburide and metformin. The totum showed a percentage inhibition of 63.66 ± 0.54% for 1 mg/mL of extract and an IC 50 of 0.031 ± 0.001 µg/mL .A 200 mg/kg extract has shown a very good antihyperglycaemic activity; while on normal blood sugar, the activity was not important compared with glyburide and metformin. These results show the presence of antioxidant and normoglycaemic substances in aqueous macerated of Euphorbia hirta L.

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“…The weak antibacterial activities of the methanol extract of E. abyssinica stem bark have also been reported 38 , validating the low inhibitory potential of the plant as documented herein. The presence of alkaloids, flavonoids, tannins, saponins and cardiac glycosides have been reported in E. abyssinica and E. africana 13,39 .…”

Section: Teke and Almentioning

confidence: 97%

Activities of selected medicinal plants against multi-drug resistant Gram-negative bacteria in Cameroon

Tchana

Fankam²,

Mbaveng³

et al. 2014

Afr H. Sci.

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Evaluation of Antioxidant Activity, Total Phenolic and Flavonoid Contents of Entada africana Guill. et Perr. (Mimosaceae) Organ Extracts

Cited by 31 publications

References 32 publications

Isolation, characterization and biological properties of betulin from Entada africana Guill. and Perr. (Mimosaceae).

Isolation, characterization and biological properties of betulin from Entada africana Guill. and Perr. (Mimosaceae).

Antioxidant and anti-hyperglycaemic activity of <i>Euphorbia hirta</i> L. on Wistar rats

Activities of selected medicinal plants against multi-drug resistant Gram-negative bacteria in Cameroon

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