Evaluation of antitumor effects of two vine stalk oligomers of resveratrol on a panel of lymphoid and myeloid cell lines: Comparison with resveratrol

Barjot, Catherine; Tournaire, Magali; Castagnino, Chantal; Vigor, Claire; Vercauteren, Joseph; Rossi, Jean‐François

doi:10.1016/j.lfs.2007.08.047

Cited by 44 publications

(41 citation statements)

References 39 publications

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“…It is tempting to speculate that a putative interaction between raftmediated processes triggered by resveratrol and proteasome inhibition might lead to a potent cell death response. Two naturally occurring resveratrol oligomers, eviniferin and miyabenol C, have been shown to promote apoptosis in lymphoid and myeloid cell lines at lower doses than resveratrol (Barjot et al, 2007). Further investigation on the mode of action of these natural oligomers might set new frameworks for cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions

2009

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We have found that resveratrol (trans-3,4 0 ,5-trihydroxystilbene) induced apoptosis in multiple myeloma (MM) and T-cell leukemia cells through coclustering of Fas/ CD95 death receptor and lipid rafts, whereas normal lymphocytes were spared. Tumor necrosis factor-related apoptosis-inducing ligand receptors, Fas-associated death domain-containing protein (FADD), procaspase-8, procaspase-10, c-Jun amino-terminal kinase and Bid were also recruited into lipid rafts on resveratrol incubation with MM and T-cell leukemia cells. Raft disruption inhibited resveratrol-induced apoptosis. Bcl-X L overexpression prevented resveratrol-induced disruption of mitochondrial transmembrane potential (DW m ) and apoptosis. A FADD dominant-negative mutant, that blocked Fas/CD95 downstream signaling, precluded resveratrolinduced DW m loss and apoptosis, indicating a sequence of Fas/CD95 signaling-mitochondrion in the apoptotic response triggered by resveratrol. Cells deficient in Fas/CD95 did not undergo resveratrol-induced apoptosis. Pretreatment of MM cells with interferon-g upregulated Fas/CD95 and caspase-8, and potentiated resveratrolinduced apoptosis. Our data indicate that recruitment of Fas/CD95 death receptor and downstream signaling molecules into lipid rafts, followed by DW m disruption, underlies the apoptotic action of resveratrol in MM and T-cell leukemic cells. Combination of resveratrol with perifosine or bortezomib potentiated the apoptotic response induced by each single drug. These results also highlight the role of recruitment of Fas/CD95 signaling in lipid rafts in antimyeloma and antileukemia chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions

2009

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“…Vincristine sulphate prevents the formation of mitotic spindles, stops the cell cycle in the G2/M phase, and stimulates apoptosis (Harmsma et al 2004;Ricci and Zong 2006). However, in the present study, e-viniferin was used as an antioxidant to stop the cell cycle in the G2/M phase leading to apoptosis (Barjot et al 2007;Khan et al 2007). Since these two agents affect the cell cycle at the same phase, their usage in combination may increase each other's effects, leading to the consideration that they may be useful in decreasing the dose of vincristine sulphate acting as a chemotherapeutic agent.…”

Section: Discussionmentioning

confidence: 58%

“…There are many studies indicating the facts that dietary antioxidants suppresses the growth of a wide variety of tumor cells, maintain the integrity of normal cells, repair induced cellular damage, and remove the effect of free radicals (Barjot et al 2007;Do Amaral et al 2008;Ganesaratnam et al 2004;Ozben 2007;Sarrias ). e-Viniferin used in this study is a sample of dietary antioxidants (Barjot et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…e-Viniferin used in this study is a sample of dietary antioxidants (Barjot et al 2007). eViniferin, a dimer of resveratrol, is a polyphenolic substance.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have demonstrated that antioxidants may be used in cancer treatment. In these studies, antioxidant substances decrease the proliferation of cancerous cells in vitro and lead to apoptosis, however, they minimize side effects of chemotherapy in vivo (Barjot et al 2007;Do Amaral et al 2008;Ganesaratnam et al 2004;Ozben 2007). …”

Section: Introductionmentioning

confidence: 99%

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Direct and protective effects of single or combined addition of vincristine and ε-viniferin on human HepG2 cellular oxidative stress markers in vitro

et al. 2015

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The objective of this study is to examine the direct effects of low doses and high doses of e-viniferin, a substance known to be an antioxidant, and vincristine sulphate, a chemotherapeutic agent, alone and in combination [e-viniferin ? vincristine] on HepG2 cell strain, as well as evaluate oxidative stress after incubation periods of 3, 6, and 24 h. Direct effect was determined right after the incubation period; however, for protective effect, antioxidant protection response was determined after the treatment for 1 h with 500 lM H 2 O 2 , which is an oxidative stressor. For this purpose, superoxide dismutase was determined for enzyme activity, and lipid hydroperoxide (LPO) and reduced glutathione concentrations were studied as indicators of oxidative stress. Results show that low [3.63 lM vincristine ? 3.75 lM e-viniferin] and high [11.25 lM vincristine ? 15.8 lM e-viniferin] doses of combination groups showed similar direct antioxidant effect on LPO levels as protective when compared to the H 2 O 2 control group (p \ 0.05). Superoxide dismutase enzyme showed a direct antioxidant effect in low and high dose combination groups. In addition, when the incubation period was increased to 24 h, a protective effect was observed in both dose groups (p \ 0.05). Reduced glutathione activities showed a direct effect in the low dose combination group, and a protective effect in both the low and high doses in the 24 h. These results show that combined usage of drugs in HepG2 cell strain possesses a protective effect against exogenically produced oxidative stress conditions.

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2020

Secondary Metabolites of Medicinal Plants

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Evaluation of antitumor effects of two vine stalk oligomers of resveratrol on a panel of lymphoid and myeloid cell lines: Comparison with resveratrol

Cited by 44 publications

References 39 publications

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions

Direct and protective effects of single or combined addition of vincristine and ε-viniferin on human HepG2 cellular oxidative stress markers in vitro

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