Evaluation of apatite-coated chitosan microspheres for bone regeneration

Xu, Fei; Yin, Miao; Ding, Huifen; Song, Frank M.; Fu, Donglei; Zhang, Jiayin; Wang, Jiawei

doi:10.1007/s11595-014-0927-2

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…There was no difference in bone neoformation scores between rats and mice, as evidenced by two studies that evaluated chitosan/hydroxyapatite scaffolds. 37,38…”

Section: Discussionmentioning

confidence: 99%

“…60,61 The addition of BMP-2 to these materials improved bone neoformation because the growth factor has a well-known effect on osteoinduction. 62 However, even in the absence of BMP-2, Stephan et al 34 observed that a chitosan gel scaffold exhibited a higher bone neoformation score than a chitosan microsphere-based scaffold 38,39 or chitosan/hydroxyapatite electrospun membranes 37 in similar or shorter observation times. This indicated that scaffolds with a gel structure promoted better performance possibly due to the better flow and filling of the defect.…”

Section: Orthotropic Bone Neoformation-calvarial Defectsmentioning

confidence: 99%

“…There was no difference in bone neoformation scores between rats and mice, as evidenced by two studies that evaluated chitosan/hydroxyapatite scaffolds. 37,38 Finally, in all of the investigated materials, except for protease-sensitive polyethylene glycol (PEG-MMP), the presence of pre-differentiated or undifferentiated stem cells improved scaffold performance. For these materials, the stem cells stimulated bone neoformation and recruited other cells to the defect site.…”

Section: Orthotropic Bone Neoformation-calvarial Defectsmentioning

confidence: 99%

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The performance of bone tissue engineering scaffolds in in vivo animal models: A systematic review

2016

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Bone tissue engineering is an excellent alternative for the regeneration of large bone defects caused by trauma or bone pathologies. Scaffolds, stem cells, and bioactive molecules are the three key components of bone regeneration. Although a wide range of biomaterials of various compositions and structures has been proposed in the literature, these materials are rarely used in clinical applications. Therefore, more standardized studies are required to design scaffolds that enable better bone regeneration and are suitable for clinical use. The aim of this systematic review was to compare the performance of scaffolds used in preclinical animal studies to determine which class of materials has achieved a higher rate of bone neoformation (osteoinduction and osteoconduction). The selected studies were divided into three groups according to the following experimental models: studies that used subcutaneous models, bone defects in calvaria, and bone defects in long bones. Despite the large number of parameters in the included studies, we generally concluded that biomaterials containing calcium phosphates had important osteoinductive effects and were essential for better performance of the materials. Furthermore, natural polymers generally had better performance than synthetic polymers did, especially when the materials were associated with stem cells. The combination of materials from different classes was the most promising strategy for bone tissue regeneration.

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“…There was no difference in bone neoformation scores between rats and mice, as evidenced by two studies that evaluated chitosan/hydroxyapatite scaffolds. 37,38…”

Section: Discussionmentioning

confidence: 99%