Evaluation of bone regeneration in periapical osseous defects with and without platelet rich plasma, combined calcium sulfate and autologous bone graft – A comparative study

Nakkeeran, Komagan Prabhu; Saravanan, Kanmani; Babu, Prasoon S; John, R.R.

doi:10.1016/j.jormas.2018.11.008

Cited by 13 publications

(11 citation statements)

References 19 publications

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“…These studies included many types of jaw cysts, such as radicular cysts, keratocysts, and dentigerous cysts. Five studies reported spontaneous bone healing after enucleation[ 15 - 19 ], three studies investigated the efficacy of various bone grafts[ 20 - 22 ], and two randomized comparative studies focused on the comparison between spontaneous healing and bone grafting[ 23 , 24 ]. The article type, treatment, bone regeneration rate, quantitative assessment method of bone regeneration and overall quality of each study are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…In the last study, researchers calculated the volume of defects through cone beam computed tomography (CBCT) scans and reported the volume reduction rate[ 24 ]. In addition to size, Nakkeeran et al [ 23 ] also used a radiopacity scoring scale to further assess bone healing.…”

Section: Resultsmentioning

confidence: 99%

“…In the three studies which evaluated the efficacy of bone grafting, over 90% of bone regeneration occurred in 6 mo[ 20 - 22 ]. Meanwhile, in the two randomized comparative trials, bone grafting after cystectomy showed significant superiority over cystectomy alone, with bone regeneration rates of greater than 80% and 90% after 5 mo and 12 mo, respectively[ 23 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, the role of grafts in promoting bone formation was verified. In randomized trials in which variables were controlled, bone grafting showed a definite advantage over cystectomy within one year[ 23 , 24 ]. Other investigations on bone grafting showed complete bone healing three months after grafting, indicating the role of grafting in early bone formation[ 20 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of bone grafts in jaw cystic lesions: A systematic review

Wang¹,

Yao²,

Zhu³

2022

WJCC

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BACKGROUND Bone grafts have been applied for many years in orthopedic surgery to assist with bone repair for defects or bone discontinuity caused by trauma and tumors as well as periodontal defects. Jaw cysts are another common benign disease of the maxillofacial region which may lead to pathological bone fracture, loss of teeth, and infection. However, whether bone grafts are beneficial for bone regeneration in jaw cystic lesions and when bone grafts should be used remains unclear. AIM To study the efficacy of bone grafts compared to spontaneous healing in the treatment of jaw cystic lesions. METHODS A literature search was performed in Medline, Cochrane Library and Embase to identify related articles published in English in the last ten years. The following key words and MeSH terms were used: “jaw cyst”, “cystic lesion”, “odontogenic cyst”, “periapical cyst”, “dentigerous cyst”, “follicular cyst”, “keratocyst”, “treatment”, “surgery”, “bone graft”, “enucleation”, “cystectomy”, and “bone regeneration”. Case reports, clinical trials, clinical studies, observational studies and randomized controlled trials were included. Study quality was evaluated. RESULTS Ten studies ( n = 10) met the inclusion criteria. Five studies reported spontaneous bone healing after enucleation, three studies investigated the efficacy of various bone grafts, and two randomized comparative studies focused on the comparison between spontaneous healing and bone grafting. Over 90% of bone regeneration occurred within 6 mo after bone grafting. The bone regeneration rate after cystectomy showed great variation, ranging from 50% to 100% after 6 mo, but reaching over 90% after 12 mo. CONCLUSION While the long-term superiority of bone grafting compared with spontaneous healing after cystectomy is unclear, bone grafts accelerate the process of healing and significantly increase bone quality.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of bone grafts in jaw cystic lesions: A systematic review

Wang¹,

Yao²,

Zhu³

2022

WJCC

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“…2018, Nakkeeran et al . 2019, Sahib & Al‐Adili 2019, Soto‐Peñaloza et al . 2020), and two full‐text articles were not available (Kaiser et al .…”

Section: Resultsmentioning

confidence: 99%

Impact of different regenerative techniques and materials on the healing outcome of endodontic surgery: a systematic review and meta‐analysis

2020

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Background Regenerative techniques are increasingly applied in endodontic surgery, but different materials used in regenerative techniques may have varying impacts on wound healing. Objectives This study evaluated the effects of different regenerative techniques and materials on the outcome of endodontic surgery. Participants: patients with persistent periapical lesions, treated with root‐end surgery. Control: endodontic surgery without the use of regenerative techniques/materials. Intervention: endodontic surgery with the use of regenerative techniques/materials. Outcome: combined clinical and radiographic results. Methods PubMed, Web of Science, Embase, SinoMed and the CENTRAL Cochrane were searched up to 10th July 2020, followed by a manual search. Detailed eligibility criteria were applied. Cochrane’s risk‐of‐bias tool 2.0 was used to assess the risk of bias of the eligible studies. Meta‐analysis was conducted using RevMan software. Subgroup analyses were performed based on the regenerative materials used in endodontic surgery. Results Eleven eligible randomized controlled trials (RCTs) were included in the meta‐analysis: two had a low risk of overall bias, and nine had some concerns of overall bias. Generally, the use of regenerative techniques significantly improved the outcome of endodontic surgery (risk ratio [RR]: 0.42; 95% confidence interval [CI], 0.26–0.68; P < 0.001). On subgroup analysis, the use of expanded polytetrafluoroethylene (e‐PTFE) membranes alone had no added benefits (RR: 2.00; 95% CI, 0.22–18.33; P = 0.54). The application of collagen membranes or autologous platelet concentrates (APCs) alone was associated with a trend for better outcomes (RR: 0.51; 95% CI, 0.20–1.25; P = 0.14) (RR: 0.55; 95% CI, 0.18–1.71; P = 0.30). The combined use of collagen membranes and bovine‐derived hydroxyapatite significantly improved the outcome (RR: 0.35; 95% CI, 0.17–0.75; P = 0.007). Discussion This systematic review evaluated the effects of collagen membranes, e‐PTFE membranes, APCs and bone grafting materials, providing detailed information about the risks and benefits of using each regenerative technique/material or its combination in endodontic surgery. Conclusions Regenerative techniques improve periapical lesion healing after endodontic surgery. The combined use of collagen membranes and bovine‐derived hydroxyapatite may be beneficial as an adjunct to endodontic surgery. In contrast, the positive efficacy of e‐PTFE membranes or APCs alone remains doubtful.

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