Evaluation of cases of pemphigus vulgaris and pemphigus foliaceus from a reference service in Pará state, Brazil

Pires, Carla Andréa Avelar; Viana, Viviane Brito; Araújo, Fernando Costa; Müller, Silvia Ferreira Rodrigues; Oliveira, Miguel Saraty de; Carneiro, Francisca Regina Oliveira

doi:10.1590/abd1806-4841.20142679

Cited by 26 publications

(23 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 and 12 weeks respectively. Similar results were observed in different studies with corticosteroid alone, 17 corticosteroid plus azathioprine 18 and corticosteroid plus rituximab 19 treatment in Pemphigus vulgaris. Corticosteroid decreases inflammation by suppressive effects on cytokines and other mediators of inflammation.…”

Section: Quality Of Lifesupporting

confidence: 77%

An Evaluation of Pharmacological Management of Pemphigus Vulgaris and its Impact on Quality of Life

M¹,

M²,

P³

et al. 2018

JYP

View full text Add to dashboard Cite

Pemphigus vulgaris is a rare autoimmune blistering disease of skin and mucous membranes. The Worldwide incidence of Pemphigus vulgaris is 0.5 to 3.2 cases per one lakh populations/year. 1 In India, incidence of Pemphigus vulgaris is 4.4 cases per million populations/year. 2 Patients of Pemphigus vulgaris are presented with flaccid, thin walled vesicles and/ or bullae which are commonly rupture to leave an area of erosion and ulceration. Involvement of various mucosal surfaces such as oral, ocular, nasal, pharyngeal, laryngeal, upper respiratory and anogenital mucous membrane is present in Pemphigus vulgaris. Majority of patients with Pemphigus vulgaris develop painful erosions of the oral and skin lesion due to involvement of peripheral nerves. 3 The choice of therapy depends on severity of the disease, efficacy, safety, availability and cost of drugs. 4 Corticosteroid are preferred therapy for Pemphigus vulgaris, azathioprine is used for its corticosteroid-sparing effect and it is first line adjuvant immunosuppressant agent. 5 Rituximab, an anti-CD20 monoclonal antibody is indicated for moderate to severe refractory cases, contraindication or severe ADR to systemic corticosteroids and immunosupressants. 6 High-dose Intravenous immunoglobulin G (IVIG) and plasmapheresis can also be indicated in resistant cases. 5 Disease symptoms e.g. painful lesions, disease severity and complications due to treatment e.g. ADR may adversely affect the quality of life of patients. 7 Therefore, quality of life measures can be used to guide and evaluate treatment interventions. During extensive literature search, we observed studies reported from different countries about efficacy (i.e. Pemphigus area and activity score, Pemphigus disease area index), evaluation of quality of life (i.e. skindex-29, short form-36, autoimmune Bullous Disease Quality of Life Questionnaire) and correlation of efficacy and QOL in patients of Pemphigus vulgaris. 8-10 We did not find any Indian study showing efficacy and correlation of efficacy with QOL over a period of time. Hence, this study was carried out to study the use and effect of the drugs as well as its impact on quality of life in patient suffering from Pemphigus vulgaris. MATERIALS AND METHODS Permissions to conduct the study were obtained from the Institutional Ethics committee (IEC No-208/15) and the Head of Department of Dermatology and Venereology. All newly diagnosed patients of Pemphigus vulgaris by Dermatologist, between 18 to 65 years of either gender, who are willing to participate in the study and gave written informed consent were enrolled. Patients who were suffering from severe or uncontrolled cases of hypertension, diabetes mellitus, hepatic, renal, pulmonary, hematologic disorders and pregnant as well as lactating women were excluded. This was an observational, prospective, single center study carried out at department of skin and venereal disease of a tertiary care teaching hospital over a period of 24 months from November 2015 to November 2017. The baseline data like demograp...

show abstract

Section: Quality Of Lifesupporting

confidence: 77%

An Evaluation of Pharmacological Management of Pemphigus Vulgaris and its Impact on Quality of Life

M¹,

M²,

P³

et al. 2018

JYP

View full text Add to dashboard Cite

show abstract

“…La fréquence du pemphigus observée dans notre étude (10 cas/an) était comparable à celle rapportée en Afrique du Sud (9,33 cas/an), mais plus faible qu'en Tunisie (18,4cas/ an) et au Brésil (12,66 cas/an) [12,15,16]. Cette différence pourrait s'expliquer par l'existence de formes endémiques dans ces 2 régions.…”

Section: Discussionunclassified

“…L'âge de survenue semble plus précoce dans le PV (29 ans) que dans les pemphigus superficielles (51 ans). Par contre, le pemphigus survient plus précocément en Tunisie (28 ans) et au Brésil (25 ans), et plus tardivement en Europe (50-70 ans), avec un âge moyen de 62 ans en Allemagne [6,15,16].…”

Section: Discussionunclassified

See 1 more Smart Citation

Epidemiological and clinical aspects of pemphigus in Senegal

Diallo¹,

Diatta²,

Diop³

et al. 2017

Our Dermatol Online

View full text Add to dashboard Cite

Background: The purpose of this study was to specify the epidemiological and clinical characteristics of pemphigus in the Department of Dermatology of the University Hospital of Dakar. Patients and Methodology: All medical records of patients seen for pemphigus in our department over a 11-year period were analyzed retrospectively. Results: We collected 105 cases of pemphigus, corresponding to a frequency of 10 cases/year and a hospital prevalence of 2.7%. Thus, pemphigus held the second rank of blistering autoimmune bullous diseases after bullous pemphigoid. The mean age of patients was 47.62 years and the age group [40-59 years] was predominantly affected (28 cases; 45 %). There were 41 femeles and 21 men (F/M ratio: 2). We did not find an endemic focus in our country. Clinical forms were dominated by pemphigus foliaceus (30 cases; 48.5 %), followed by pemphigus vulguaris (19 cases; 30.6 %) and finally by pemphigus erythematosus (13 cases; 21%). In 16 cases (25 %), the pemphigus had begun after the consumption of a traditional medicinal plant (8 cases). An associated toxidermia was found in12 cases. Pruritus was present in 43 patients (69.35%). Discussion: In Senegal, pemphigus are common diseases, but without however an endemic focuc. They occur in young women, with a predominance of superficial forms, especially pemphigus foliaceus. The presence of pruritus and associated toxidermia to traditional medicinal plants are common.

show abstract

“…To our knowledge, there is no expressive number of reports concerning PV epidemiology in Brazil. Only one study in NSPS reported an increase in PV cases during a 21-year period, 28 and a smallseries of 20 cases (10 PV cases) in Pará state 33 compared its behavior with PF in the same region. Gonçalves et al 28 demonstrated that new cases of PF were decreasing, being overtaken since 1998 by new cases of PV.…”

Section: Discussionmentioning

confidence: 99%

Spatial Distribution of Pemphigus Occurrence over Five Decades in Southeastern Brazil

Celere

Vernal

Serra

et al. 2017

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Well-defined locations of pemphigus cases support the hypothesis of environmental factors' involvement in its etiopathogenesis; however, these foci have never been described using specialized geographical tools. This is the first report to geo-reference pemphigus cases in a high-prevalence Brazilian region using geographic information systems. We aimed to report the spatio-temporal behavior of pemphigus foliaceus (PF) and vulgaris (PV) in southeastern Brazil, over the last five decades to describe geographical clusters, as well as to characterize the land use in the city with the highest number of cases. Patients were identified from 1965 to 2014. Maps were developed using ArcGIS software and organized into decades from 1965 to 2014. Ribeirão Preto was identified as the city with the greatest number of cases. Land use was analyzed within a 2 km-buffer surrounding the residence of each patient. A total of 426 cases of pemphigus were identified. PF was the predominant form (285 cases); notwithstanding, the number of new cases of PV rose, overtaking the number of new cases of PF in the last decade studied. Agricultural area (42%) and exposed soil (33.2%) are the most predominant land uses in Ribeirão Preto surrounding patients' residences. This study shows high-confidence geographical foci of PF and PV, as well as provides evidence of an increase of both clinical forms over the last five decades. All cases of PV and PF are in proximity to rivers and agricultural areas which reinforce the hypothesis that environmental factors play a role in pemphigus etiopathogenesis.

show abstract

Evaluation of cases of pemphigus vulgaris and pemphigus foliaceus from a reference service in Pará state, Brazil

Cited by 26 publications

References 23 publications

An Evaluation of Pharmacological Management of Pemphigus Vulgaris and its Impact on Quality of Life

An Evaluation of Pharmacological Management of Pemphigus Vulgaris and its Impact on Quality of Life

Epidemiological and clinical aspects of pemphigus in Senegal

Spatial Distribution of Pemphigus Occurrence over Five Decades in Southeastern Brazil

Contact Info

Product

Resources

About