Evaluation of Central and Peripheral Analgesic Activity of Whole Plant Gomphrena Globosa (L) (Family: Amaranthaceae)

Abstract

Gmophrena globosa (L) including in Amaranthaceae family is an important medicinal plant in our country, especially in hilly tribal people for their folk medicinal practices. The object of my study was to investigate the central and peripheral analgesic activity of the investigated plant based on the use of Gmophrena globosa extract for the wound healing to the tribal people in our country. After collection of whole plant it was first of all washed and then sun dried and made powder by grinding machine. The powder was extracted by methanol. Around 5gm of concentrated methanolic plant extract was partitioned by modified Kupchan partitioning protocol into n-hexane soluble fraction, carbon tetrachloride soluble fraction, chloroform soluble fraction and aqueous soluble fraction. All the fractions were subjected to the investigation of central and peripheral analgesic activity. Among all the fractions crude methanolic extract, nhexane soluble fraction and aqueous soluble fraction at a dose of 400mg/kg had shown significant analgesic activity. They produced an inhibition of writhing 74.6%, 71.4% and 74.5% respectively in comparable with positive control diclofenac. On the other hand central analgesic activity of the test samples were compared with Morphine. The crude methanolic extract and n-hexane soluble fraction have significant central analgesic activity at 400mg/kg dose. The central analgesic activity is highest after 30minutes. As the time progress the analgesic activity decreases. After 60minutes there is almost no central analgesic activity in the plant extracts.