Evaluation of Clinical Outcomes With Alvimopan in Clinical Practice

Delaney, Conor P.; Craver, Christopher; Gibbons, Melinda M.; Rachfal, Amy W.; Vandepol, C.; Cook, Suzanne F.; Poston, Sara; Calloway, Michael; Techner, Lee

doi:10.1097/sla.0b013e31824a36cc

Cited by 49 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the large-scale report of alvimopan used in treatment of 3525 patients after open or laparoscopic bowel resection revealed that the administration of alvimopan reduced the length and costs of hospitalization [153]. Lower incidence of GI morbidity, mortality and intensive care unit (ICU) stay were also reported.…”

Section: Opioid System In Pathophysiological Conditions Of the Gi Tractmentioning

confidence: 99%

Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

et al. 2013

View full text Add to dashboard Cite

Opioid receptors are widely distributed in the human body and are crucially involved in numerous physiological processes. These include pain signaling in the central and the peripheral nervous system, reproduction, growth, respiration, and immunological response. Opioid receptors additionally play a major role in the gastrointestinal (GI) tract in physiological and pathophysiological conditions. This review discusses the physiology and pharmacology of the opioid system in the GI tract. We additionally focus on GI disorders and malfunctions, where pathophysiology involves the endogenous opioid system, such as opioid-induced bowel dysfunction, opioid-induced constipation or abdominal pain. Based on recent reports in the field of pharmacology and medicinal chemistry, we will also discuss the opportunities of targeting the opioid system, suggesting future treatment options for functional disorders and inflammatory states of the GI tract.

show abstract

Section: Opioid System In Pathophysiological Conditions Of the Gi Tractmentioning

confidence: 99%

Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Good analgesia promotes early activities of patients, reduces complications, improves selfcare ability in daily life, and accelerates recovery. Early getting out of bed helps improve blood circulation throughout the body, can effectively reduce the occurrence of complications, such as deep vein thrombosis and pulmonary infection, promote patient recovery, shorten postoperative hospital stay, improve quality of life, and reduce economic pressure (14)(15)(16). Respiratory system management is an important part of ERAS and runs through the entire operation period.…”

Section: Eras Could Reduce the Occurrence Of Complications After Surgerymentioning

confidence: 99%

Application of and Clinical Research on Enhanced Recovery After Surgery in Perioperative Care of Patients With Supratentorial Tumors

Zhang

Chen

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

PurposeThis study intends to explore the safety and effectiveness of the concept of enhanced recovery after surgery (ERAS) in the perioperative care of patients with supratentorial tumors.MethodsA total of 151 supratentorial tumor patients were enrolled in this study, and they were divided into control group (n = 75) and observation group (n = 76) according to the random number table method. Patients in the control group received routine neurosurgery care, and patients in the observation group received enhanced recovery after surgery care. The incidence of perioperative complications, postoperative hospital stays, early postoperative eating time, catheter removal time, and time to get out of bed were observed for the two groups of patients, and the quality of postoperative recovery was evaluated.ResultsThere was no statistically significant difference in the basic data of the two groups of patients, such as age, gender, lesion location, and condition (P>0.05), and they were comparable. The observation group’s postoperative eating time, catheter removal time, and time to get out of bed were significantly earlier than those of the control group. Postoperative hospital stays and hospitalization expenses were less than those of the control group. There was a statistically significant difference in postoperative hospital stay between the two groups (P<0.05).ConclusionApplying the ERAS concept to implement perioperative care for patients with supratentorial tumors is safe and effective. It can not only reduce after-surgical stress and accelerate postoperative recovery, but also shorten hospital stays and reduce hospital costs. It is worthy of clinical application.

show abstract

“…380–382 Most of the nonrandomized studies have shown modest benefits in favor of alvimopan for laparoscopic resection albeit within traditional care pathways. 383–385 Given the low quality of the available evidence, it may be difficult to justify the use and cost of alvimopan in laparoscopic surgery in the setting of an ERP.…”

Section: Postoperative Interventionsmentioning

confidence: 99%

“…[380][381][382] Most of the nonrandomized studies have shown modest benefits in favor of alvimopan for laparoscopic resection albeit within traditional care pathways. [383][384][385] Given the low quality of the available evidence, it may be difficult to justify the use and cost of alvimopan in laparoscopic surgery in the setting of an ERP. Urinary catheterization is routinely used in abdominal and pelvic colorectal surgery for intraoperative bladder decompression and monitoring urinary output.…”

Section: Sham Feeding (Ie Chewing Gum For ≥10 Min 3-4×mentioning

confidence: 99%

Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons

Irani

Hedrick

Miller

et al. 2022

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

Funding/Support: None reported.Financial Disclosure: The funding bodies (ASCRS and SAGES) did not influence the content of this work, and no other specific funding was received from other entities. This publication was approved by both the ASCRS and SAGES executive council and then peer-reviewed by the Diseases of the Colon & Rectum and Surgical Endoscopy And Other Interventional Techniques. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. Either citation can be used when citing this article. In order to encourage its wide dissemination, this article is freely accessible on Surgical Endoscopy And Other Interventional Techniques and Diseases of the Colon & Rectum journal web sites.

show abstract

Evaluation of Clinical Outcomes With Alvimopan in Clinical Practice

Cited by 49 publications

References 38 publications

Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

Application of and Clinical Research on Enhanced Recovery After Surgery in Perioperative Care of Patients With Supratentorial Tumors

Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons

Contact Info

Product

Resources

About