Evaluation of CNS activity of<i>Bramhi Ghrita</i>

Achliya, GS; Wadodkar, Sudhir G.; Dorle, A. K.

doi:10.4103/0253-7613.13853

Cited by 45 publications

(30 citation statements)

References 5 publications

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“…4 All these plants are as Medhya (intellect promoting). The CNS activity of this formulation and its effect on learning and memory paradigm in normal animals have been reported by Achilya GS et al 3 The individual plant drugs have also been reported to possess CNS stimulation activity. [5][6][7][8] Hence the present study was planned to study the effect of this formulation in the scopolamine-induced amnesia model in rats using Cook"s pole apparatus.…”

mentioning

confidence: 53%

Evaluation of the efficacy of Brahmi ghrita in scopolamine induced amnesia in rats using Cook's pole apparatus

Munshi

Bhalerao

Nesari

2016

Int J Basic Clin Pharmacol

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mentioning

confidence: 53%

Evaluation of the efficacy of Brahmi ghrita in scopolamine induced amnesia in rats using Cook's pole apparatus

Munshi

Bhalerao

Nesari

2016

Int J Basic Clin Pharmacol

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“…Followed by the treatment, mice were noticed for the incidence and duration of extensor tonus was noted (Achliya et al, 2005).…”

Section: Electro-shock Induced Seizure Modelmentioning

confidence: 99%

Evaluation of Central Nervous System Activities of Cyperus rotundus L. Extract on Rodents

Sheik¹,

Vedhaiyan²,

Sengottuvelu³

2014

Current Research in Neuroscience

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Cyperus rotundus Ethanolic Extract (EECR) investigated for antidepressant, anxiolytic, anticonvulsant and hypnotic and muscle relaxant activities in two different animal models to find out its scientific values. Oral administration of EECR at doses of 200 and 400 mg kgG 1 on various behavioural models such as tail suspension, hole-board, elevated-plus-maze, locomotor, strychnine, maximal electroshock induced seizure, pentylenetetrazole, rotarod, climbing an inclined screen in mice and forced swim light-dark box models in rats was utilized. In the open field test, EECR (200 and 400 mg kgG 1 ) (p<0.05, p<0.01) increased in numbers of rearing. However, the number of central motor and ambulation reduced. The number of entries and the time spent in the open arm were increased while the number of locomotion was decreased (p<0.01) in elevated-plus-maze and actophotometer test, respectively. The EECR (200 and 400 mg kgG 1 ) protected the mice against the pentylenetetrazole and strychnine induced convulsions; it causes significant (p<0.05 and p<0.01) dose dependent increase in latency of convulsion. Treatment with EECR decreased the duration of the tonic hind limb extension induced by electroshock. The EECR treatment also significantly increased the hypnotic's time and decreased motor co-ordination of experimental animals. These findings are consistent with the hypothesis that C. rotundus treatment triggers immobility behavior, time spent in light, locomotor and climbing time in rat and mice model. Further studies will confirm the mechanism of action of C. rotundus for CNS drug development.

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“…This may also suggest that the anticonvulsant action of the formulation is mediated by the chloride channel of the GABA / benzodiazepine receptor complex. 27 Ficus religiosa Linn. (Ashvath) extract showed no toxicity, potentiated pentobarbitone induced sleep and inhibited seizures induced by MES and picrotoxin in a dose dependent manner.…”

Section: Anticonvulsant Activitymentioning

confidence: 99%

Current Trends in Ayurvedic Management of Cerebral Palsy in Children

Verma¹,

Singhal²

2013

J Biol Sci Opin

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Cerebral palsy is most common motor disability affecting a large paediatric population worldwide. Children affected with the disease presents with developmental delay and motor deficits and may have one or more associated problems like mental retardation, seizures, feeding difficulties along with ophthalmologic and hearing impairments. Currently there is no specific treatment in conventional system for the brain insults leading to motor dysfunction in cerebral palsy. The existing therapeutic options are mostly symptomatic and place cerebral palsy amid the costliest chronic childhood conditions. Ayurveda recommend multiple treatment options for cerebral palsy. Out of these treatment options herbal drugs, Panchakarma therapies and yoga are most acclaimed for this disease. This paper reviewed various clinical and experimental studies to ascertain efficacies of these modalities and found that Ayurveda can efficiently manage cerebral palsy along with its associated condition.

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Evaluation of CNS activity ofBramhi Ghrita

Cited by 45 publications

References 5 publications

Evaluation of the efficacy of Brahmi ghrita in scopolamine induced amnesia in rats using Cook's pole apparatus

Evaluation of the efficacy of Brahmi ghrita in scopolamine induced amnesia in rats using Cook's pole apparatus

Evaluation of Central Nervous System Activities of Cyperus rotundus L. Extract on Rodents

Current Trends in Ayurvedic Management of Cerebral Palsy in Children

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