Evaluation of Central Nervous System Activities of Cyperus rotundus L. Extract on Rodents

Abstract

Cyperus rotundus Ethanolic Extract (EECR) investigated for antidepressant, anxiolytic, anticonvulsant and hypnotic and muscle relaxant activities in two different animal models to find out its scientific values. Oral administration of EECR at doses of 200 and 400 mg kgG 1 on various behavioural models such as tail suspension, hole-board, elevated-plus-maze, locomotor, strychnine, maximal electroshock induced seizure, pentylenetetrazole, rotarod, climbing an inclined screen in mice and forced swim light-dark box models in rats was utilized. In the open field test, EECR (200 and 400 mg kgG 1 ) (p<0.05, p<0.01) increased in numbers of rearing. However, the number of central motor and ambulation reduced. The number of entries and the time spent in the open arm were increased while the number of locomotion was decreased (p<0.01) in elevated-plus-maze and actophotometer test, respectively. The EECR (200 and 400 mg kgG 1 ) protected the mice against the pentylenetetrazole and strychnine induced convulsions; it causes significant (p<0.05 and p<0.01) dose dependent increase in latency of convulsion. Treatment with EECR decreased the duration of the tonic hind limb extension induced by electroshock. The EECR treatment also significantly increased the hypnotic's time and decreased motor co-ordination of experimental animals. These findings are consistent with the hypothesis that C. rotundus treatment triggers immobility behavior, time spent in light, locomotor and climbing time in rat and mice model. Further studies will confirm the mechanism of action of C. rotundus for CNS drug development.

Citrus maxima (Brum.) Merr. (Rutaceae): Bioactive Chemical Constituents and Pharmacological Activities

“…The exact mechanism for exhibiting antidepressants was not reported, but it might be due to enhancement of norepinephrine neurotransmission in mice [ 20 ]. Similarly, the per-oral administration of ethanolic extracts (200 and 400 mg/kg) of C. maxima in mice increased the number of rearing in both the TST and FST models while imipramine (1 mg/kg) noticeably reduced the immobility time [ 86 ].…”

Analisis Korespondensi untuk Mengetahui Atribut Unggulan Jeruk Pamelo: Studi Kasus Pada Empat Aksesi Jeruk Pamelo di Magetan (Correspondence Analysis to Identified the Superior Attribute of Pummelo: Case Study on Four Pummelo Accession in Magetan)

“…Pamelo memiliki potensi untuk dikembangkan di Indonesia merujuk karakteristiknya yang unik, baik dari sisi ukuran, rasa, maupun lama penyimpanan (Aji et al 2017). Menurut beberapa penelitian, tanaman ini memiliki manfaat untuk kesehatan, misalnya daun untuk penyakit epilepsi (Sheik, Vedhaiyan & Singaravel 2014), bunga sebagai obat penenang (Stewart 1985), buah memiliki potensi sebagai obat diabetes (Oyedepot & Babarinde 2013), selain mengandung vitamin C yang tinggi (Xu et al 2008), sedang batang dan akar dapat digunakan mengatasi mikrobe (Barrion et al 2014;Dubey, Kumar & Tripathi 2004). Pamelo dapat tumbuh dan berproduksi pada ketinggian tempat 100 -400 m dpl., di berbagai jenis tanah, dan merupakan tanaman tahunan, yang berbunga dan berbuah dua sampai empat kali dalam setahun.…”

Methanolic Extract of Peel of Citrus maxima Fruits Exhibit Analgesic, CNS Depressant and Anti-inflammatory Activities in Swiss Albino Mice

“…9 Bactericidal activity of the leaves, peel and pulp is also reported. [10][11][12][13] While bark of this plant is reported to have anti-diabetic activity. 11 In this study we evaluated the analgesic, anti-inflammatory and central nervous system (CNS) depressant activity of methanolic extract of peel of Citrus maxima fruits.…”

“…[10][11][12][13] While bark of this plant is reported to have anti-diabetic activity. 11 In this study we evaluated the analgesic, anti-inflammatory and central nervous system (CNS) depressant activity of methanolic extract of peel of Citrus maxima fruits. malin, the mice were observed for 30 min and the time spent licking of the injected hind paw was recorded.…”