Evaluation of commercial soft contact lenses for ocular drug delivery: A review

Fan, Xin; Torres-Luna, Cesar; Azadi, Marjan; Domszy, R. C.; Hu, Naiping; Yang, Arthur; David, Allan E.

doi:10.1016/j.actbio.2020.08.025

Cited by 49 publications

(19 citation statements)

References 149 publications

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“…With the rapid growth in the aging population and the prevalence of electronic products, the number of people afflicted with ocular diseases (cataracts, dry eye syndrome, infections, glaucoma, age-related macular degeneration, etc.) is increasing year by year [ 1 ]. Topical delivery (i.e., eye drops and ointments), is the preferred route of administration and accounts for more than 90% of ophthalmic formulations on the market [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…They are biocompatible, safe, durable and comfortable, thus providing a new route for ophthalmic drug delivery [ 6 ]. Numerous animal studies demonstrated that ophthalmic medications delivered by therapeutic contact lenses could prolong the time a drug stays on the cornea and increase its bioavailability by at least 50%, compared with eye-drop formulations [ 1 , 7 ]. A conventional soaking method is the most straightforward and cost-effective way to load drugs into contact lenses [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Wang

Zhang

et al. 2021

Nanomaterials

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Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability have been developed to circumvent tedious eye drop instillation. In this work, zwitterionic nanogels based on poly(sulfobetaine methacrylate) (PSBMA) were easily fabricated by one-step reflux-precipitation polymerization, with the advantages of being surfactant-free and morphology controlled. Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels. A set of contact lenses with varied nanogel-loading content was fabricated by the cast molding method, with the drug-loaded nanogels dispersed in pre-monomer solutions composed of 2-hydroxyethyl methacrylate (HEMA) and N-vinyl-2-pyrrolidone (NVP). The structure, surface morphology, water contact angle (WCA), equilibrium water content (EWC), transmittance, and mechanical properties of the contact lenses were subsequently investigated, and in vitro drug release and biocompatibility were further evaluated. As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Wang

Zhang

et al. 2021

Nanomaterials

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“…[6] Copyright 2016, ACS. Alden Optical Drug delivery Developed (Alden HP) [113] as there was weak correlation between glucose in the tear and blood. As another example, InWith Corporation and Bausch & Lomb have investigated to create an augmented reality contact lens.…”

Section: Market and Regulatory Process For Smart Contact Lensesmentioning

confidence: 99%

Smart Contact Lenses for Biosensing Applications

Ahadian

Liu

et al. 2021

Advanced Intelligent Systems

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Smart contact lenses have emerged as novel wearable devices. Due to their multifunctional biosensing capabilities and highly integrated performance, they provide a great platform for the diagnosis of eye diseases and the delivery of drugs. Herein, a brief history of the development of contact lenses is given. Then, the state‐of‐the‐art design and fabrication of smart contact lenses for biomedical applications, including contact lens materials, fabrication technologies, and integration, are presented. Furthermore, biosensors implemented in contact lenses to measure lactic acid, glucose, intraocular pressure, and other key metabolites in tears are highlighted. Applications of smart contact lenses in drug delivery are also described. These unique features make smart contact lenses promising diagnostic and treatment devices. Challenges and future opportunities for further applications of smart contact lenses in biomedicine are also discussed.

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“…The human eye is a complex system, so the administration of drugs to the eye is in continuous research. Studies are designed to develop modern drug delivery systems that increase the delivery of the active pharmaceutical ingredient to the ocular system [1], such as inserts [2,3], contact lenses [4], hydrogels [5], nanostructured lipid carriers, nanoparticles, liposomes [1] and so on. Certain systems may cause discomfort to the patient in the eye system, and in some situations, the method of administration is invasive.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Chitosan-Hydroxypropyl Methylcellulose In Situ Gelling Systems for Ophthalmic Delivery of Bupivacaine Hydrochloride

et al. 2021

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The aim of this study was the development and optimization of chitosan and hydroxypropyl methylcellulose (HPMC) in situ gelling systems, loaded with bupivacaine hydrochloride for topical ocular administration. This study is based on the properties of two polymers: chitosan, which has mucoadhesive action and is a pH-sensitive polymer, but also the cellulose derivative hydroxypropyl methylcellulose, a thermosensitive polymer which has mucoadhesive properties and increases the viscosity of systems. The analysis and optimization of in situ gelling systems were performed based on an experimental design and response surface methodology. The following formulation parameters were considered: X1 = chitosan concentration (0.5%, 1%), X2 = HPMC E 5 LV concentration (2%, 5%) and X3 = Chitosan/HPMC E 5 LV ratio (1/1, 2/1). In addition, the parameters to be optimized were represented by the contact angle (CA (°)), viscosity and cumulative percentage of bupivacaine hydrochloride released in vitro. The results indicate that the designed in situ gelling systems are suitable for bupivacaine prolonged ophthalmic release and overcome the principal disadvantages of the liquid’s ocular formulations. An immediate therapeutic effect corresponding to ocular anesthetic installation was assured in the first stage: burst bupivacaine release. In the second phase, the gradual drug release was assured for over 6 h. This drug release profile, together with the corresponding rheological profile and a collection of superficial properties for good ocular adhesion balanced with an adequate hydrophilic character, assured the desired quality of the attributes for the proposed systems. The system, based on chitosan 1%, HPMC E 5 LV 5% and a 1/1 polymer ratio, could be a solution for the proposed formulation of in situ gelling colloidal systems, since the viscosity of the system was within the range of the optimal viscosity of the eye, and the amount of bupivacaine hydrochloride released after 6 h was the highest at 69.55%.

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Evaluation of commercial soft contact lenses for ocular drug delivery: A review

Cited by 49 publications

References 149 publications

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Smart Contact Lenses for Biosensing Applications

Development and Optimization of Chitosan-Hydroxypropyl Methylcellulose In Situ Gelling Systems for Ophthalmic Delivery of Bupivacaine Hydrochloride

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