Evaluation of cysteamine supplementation in red tilapia (Oreochromis sp.) diet: Serum insulin and somatostatin, IGF-1 and GLUT4 genes expression, growth performance, and robustness against stress

Wardani, Wira Wisnu; Alimuddin, Alimuddin; Zairin, Muhammad; Setiawati, Mia; Nuryati, Sri; Suprayudi, Muhammad Agus

doi:10.1016/j.aquaculture.2020.735514

Cited by 10 publications

(16 citation statements)

References 37 publications

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“…The oxidative protein deamination will accelerate the excretion rate of ammonia to the aquatic environment, which may accumulate within the system and harm the fish itself (Lazzari & Baldisserto, 2008). In other side, insulin promoting higher utilization of energy and reducing oxidative stress in red tilapia (Wardani et al, 2020). Insulin levels (Kao et al, 1998;Very et al,.…”

Section: Introductionmentioning

confidence: 99%

Growth performance, robustness against stress, serum insulin, IGF‐1 and GLUT4 gene expression of red tilapia (Oreochromis sp.) fed diet containing graded levels of creatine

et al. 2020

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The experimental diets containing five levels of creatine supplementation, namely control (N = 0 g/kg creatine), B1 (1.00 g/kg glycine), B2 (0.40 g/kg creatine), B3 (0.80 g/kg creatine) and B4 (1.20 g/kg creatine) were tested to red tilapia up to apparent satiation 3 times a day for 56 days. After the feeding trial, fish were stressed by air exposure for challenge test against stress. The results described that creatine supplementation improved final body weight, feed conversion ratio (FCR) and protein retention. Creatine supplementation decreased blood glucose, cholesterol and triglyceride levels (p < .05), indicating more effective usage of non‐protein energy. Furthermore, creatine supplementation also increased plasma insulin levels and upregulated IGF‐1 and GLUT4 gene expressions in the liver significantly; it also improved robustness against stress, which was shown by higher superoxide dismutase, higher postchallenge survival and plasma cortisol, malondialdehyde and lower glucose levels. In conclusion, creatine supplementation at a dose of 0.289–0.389 g/kg diet escalated fish growth and improved robustness against stress via improving the SOD activity in red tilapia.

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Section: Introductionmentioning

confidence: 99%

Growth performance, robustness against stress, serum insulin, IGF‐1 and GLUT4 gene expression of red tilapia (Oreochromis sp.) fed diet containing graded levels of creatine

et al. 2020

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“…The oxidative protein deamination will accelerate the excretion rate of ammonia to the aquatic environment, which may accumulate within the system and harm the fish itself (Lazzari & Baldisserotto, 2008). Synergistic of cysteamine as an insulin stimulator through suppressing somatostatin production (Wardani et al, 2020a; Xiao & Lin, 2003) and creatine as an energy buffer ready to use (Borchel et al, 2014; Wardani et al, 2020b) in fish.…”

Section: Discussionmentioning

confidence: 99%

“…agalactiae as immune modulator. As non‐specific immune responses, these can be through phagocytosis activity (Dawood et al, 2020), producing more super antioxidant (Table 6) to neutralize stress oxidative (Abdel‐Daim et al, 2019, 2020; Wardani et al, 2020a, 2020b) and improving lysozyme activity (Table 6) during challenge infectious.…”

Section: Discussionmentioning

confidence: 99%

“…Challenge in tilapia culture is how to increase the protein sparring effect action so that protein requirement can be reduced, and this is in line with the reduction in the incidence of oxidative deamination (Lupatsch et al, 2010). This phenomenon will increase protein retained (Schrama et al, 2018; Wardani et al, 2020a, 2020b) and improve the feed efficiency (Skov et al, 2017; Wardani et al, 2020a, 2020b), as well as reducing the ammonia excretion and heat production during the metabolic process (Andersen et al, 2016; Lazzari & Baldisserotto, 2008), and increasing immunity and fish health status. Moreover, intensive fish culture and toxin in the water (Abdel‐Daim et al, 2019, 2020) will increase death potency on the cultured fish.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to metabolic processes and cultivation systems, age and method of storage (Fonseca et al, 2013; Goes et al, 2019; Morais et al, 2019) can affect the quality of tilapia fillet. The optimal dosage for cysteamine is reported as 0.59 g/kg of feed (Wardani et al, 2020a), while for creatine is 0.289–0.389 g/kg of feed (Wardani et al, 2020b) for tilapia. The right doses combination of cysteamine and creatine is thought to improve growth performance, fillet quality and immunity of tilapia.…”

Section: Introductionmentioning

confidence: 99%

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Growth performance, fillet quality and immunity after challenge with streptococcus agalactiae of red tilapia ( oreochromis sp .) fed diet containing cysteamine and creatine

Wardani

Ali

Zairin

et al. 2021

Aquaculture Research

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This study aimed to evaluate the effect of creatine and cysteamine supplementation on the growth performance, fillet quality and resistance to bacterial infection of Streptococcus agalactiae in red tilapia. Five types of experimental diet (quadruplicate) with the same energy and protein content were tested. These consist of N (negative control), A (0.5 g/kg cysteamine), B (0.4 g/kg creatine), C (0.5 g/kg cysteamine plus 0.4 g/kg creatine) and D (0.25 g/kg cysteamine plus 0.2 g/kg creatine). Male red tilapia (Oreochromis sp.), with average body weight of 49.51 ± 4.90 g, were kept in 175‐L tank at 10 fish/tank density for 56 days rearing period. The challenge test was carried out through injecting fish (body weight: 152.05 ± 12.2 g) with S. agalactiae 107 CFU/ml as much as 0.10 ml/fish. The results showed that treatment C (0.5 g/kg cysteamine plus 0.4 g/kg creatine) increased (p < 0.05) levels of protein retention, activity of superoxide dismutase (SOD) of the liver (p < 0.05), but decreased levels of malondialdehyde (MDA) and liver glycogen (p < 0.05). This last condition was followed by a decrease (p < 0.05) in plasma protein levels that resulted in a decline (p < 0.05) of water content and MDA of fillet after stored for 24 h. In addition, treatment C increased fish resistance to S. agalactiae infection, demonstrated by higher survival rate and lysozyme activity (p < 0.05). In conclusion, the treatment C boosts protein retention, fillet quality and robustness to pathogenic bacterial infections.

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Effects of taurine supplementation in a high-carbohydrate diet on growth performance, plasma biochemical, digestive and glucose metabolism enzymes in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus)

Qian

Yin

Liu

et al. 2021

Aquaculture Reports

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Evaluation of cysteamine supplementation in red tilapia (Oreochromis sp.) diet: Serum insulin and somatostatin, IGF-1 and GLUT4 genes expression, growth performance, and robustness against stress

Cited by 10 publications

References 37 publications

Growth performance, robustness against stress, serum insulin, IGF‐1 and GLUT4 gene expression of red tilapia (Oreochromis sp.) fed diet containing graded levels of creatine

Growth performance, robustness against stress, serum insulin, IGF‐1 and GLUT4 gene expression of red tilapia (Oreochromis sp.) fed diet containing graded levels of creatine

Growth performance, fillet quality and immunity after challenge with streptococcus agalactiae of red tilapia ( oreochromis sp .) fed diet containing cysteamine and creatine

Effects of taurine supplementation in a high-carbohydrate diet on growth performance, plasma biochemical, digestive and glucose metabolism enzymes in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus)

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