Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats

Hobbie, Kristen; Dixon, Darlene

doi:10.1177/0192623320931768

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…However, no mitosis and apoptosis were recorded in the gland cells. 25,26 In summary, the transplanted uteri from the recipient male rats showed some of the histological changes of proestrus, estrus, and diestrus of female rats. However, whether a transplanted uterus in the castrated male recipient can experience the completed reproductive cycle of female rats deserves further investigations.…”

Section: Discussionmentioning

confidence: 83%

Transplantation of the Uterus in the Male Rat

et al. 2023

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Background. Uterus transplantation (UTx) is one of the potential methods to cure absolute uterine factor infertility of transgender. However, this mostly comes with many technological challenges. Methods. Left inguinal UTx was performed in 13 castrated male rats. End-to-end anastomosis of donor common iliac vessels to recipient femoral vessels was used for transsexual UTx. Sampling was performed on day 30 after transplantation. Grafts were used to analyze the histological changes. TUNEL assay was applied to stain the apoptotic cells. Immunological rejection was judged by flow cytometry. Results. Six uteri, 4 ovaries, and 4 upper vaginas were found at day 30 posttransplantation. Similar histological changes to proestrus, estrus, and diestrus of female rats were examined in the transplanted uteri. The histological changes of transplanted vaginas showed similarity to proestrus, estrus, and metestrus of the female rats. Follicles of different stages and corpus luteum with distinct morphological appearances were also observed. The TUNEL assay revealed a higher apoptosis of granulosa cells in transplanted ovaries compared with normal ovaries. Conclusions. A rat model of transsexual unilateral inguinal uterine transplantation in castrated rats was established, which will provide a reference for bilateral transsexual UTx in animals and genetically 46 XY individuals who wish to become real women through transsexual UTx.

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Section: Discussionmentioning

confidence: 83%

Transplantation of the Uterus in the Male Rat

et al. 2023

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Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits

et al. 2021

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Animals are valuable resources in biomedical research in investigations of biological processes, disease pathogenesis, therapeutic interventions, safety, toxicity, and carcinogenicity. Interpretation of data from animals requires knowledge not only of the processes or diseases (pathophysiology) under study but also recognition of spontaneous conditions and background lesions (pathology) that can influence or confound the study results. Species, strain/stock, sex, age, anatomy, physiology, spontaneous diseases (noninfectious and infectious), and neoplasia impact experimental results and interpretation as well as animal welfare. This review and the references selected aim to provide a pathology resource for researchers, pathologists, and veterinary personnel who strive to achieve research rigor and validity and must understand the spectrum of “normal” and expected conditions to accurately identify research-relevant experimental phenotypes as well as unusual illness, pathology, or other conditions that can compromise studies involving laboratory mice, rats, gerbils, guinea pigs, hamsters, naked mole rats, and rabbits.

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Histomorphological Evaluation of Non-Neoplastic Lesions of Uterine Cervix and a Correlation of the Lesion with the Clinical Factors

Dhanaraj¹,

Ulaganathan²,

Renuka

et al. 2023

CHAMC

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Aim: This study investigates the prevalence of non-malignant lesions of the cervix among various biopsy samples. Methods: This case study consists of 50 cases of cervical biopsy for almost two years. The case history and clinical details of the patients were obtained. Results: 60% of the cases that participated in this study reported white discharge per vaginum as a common clinical symptom. 4 cases (8%) showed koilocytic changes specific to the human papillomavirus during the study. Only 2% of the nonspecific cervicitis showed lymphoid aggregates. Endocervical changes projected papillary endocervicitis with 9 cases, 18%, squamous metaplasia with 7 cases (14%), and nabothian follicle cyst with 3 cases (6%). Conclusion: It has been concluded that 50 cases were studied histologically which had adequate representation of both ecto and endocervical tissue. Moreover, 31-40 years age of patients showed the highest percentage of non-neoplastic lesions of the cervix when compared to other age groups.

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Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats

Cited by 3 publications

References 9 publications

Transplantation of the Uterus in the Male Rat

Transplantation of the Uterus in the Male Rat

Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits

Histomorphological Evaluation of Non-Neoplastic Lesions of Uterine Cervix and a Correlation of the Lesion with the Clinical Factors

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