Evaluation of Efficacy of 1% Curcuminoids as Local Application in Management of Oral Lichen Planus – Interventional Study

Thomas, Anju Elizabeth; Varma, Beena; Kurup, Seema; Jose, Renju; Chandy, Marina Lazar; Kumar, Sreeja P.; Shanmugham, Aravind M; Ramadas, Athira Aruna

doi:10.7860/jcdr/2017/20898.9715

Cited by 38 publications

(68 citation statements)

References 21 publications

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“…The improvement of the clinical aspect of the lesions was assessed using the Thongprasom scale (5 = white striae with erosive area >1 cm 2 , 4 = white striae with erosive area <1 cm 2 , 3 = white striae with atrophic area >1 cm 2 , 2 = white striae with atrophic area <1 cm 2 , 1 = only white striae, 0 = no lesions); the principal exceptions are represented by some studies that used alternative scales, but were still comparable to the classification system of Thongprasom [15,18,20,27], and three studies only recorded the dimensional change of the lesion without using any classification system [10,19,29].…”

Section: Discussionmentioning

confidence: 88%

“…The outcomes evaluated regarding these therapeutic approaches were different; in relation to the symptomatologygenerally characterized by a burning sensation and pain -the majority of studies evaluated symptoms by using the Visual Analog Scale (VAS), and 4 studies used the Numerical Rating Scale (NRS) [10,11,18,19]. Only two studies did not consider symptomatology as an outcome [15,27], while the results of one study were based exclusively on evaluating the improvement of symptoms, using the VAS [13].…”

Section: Discussionmentioning

confidence: 99%

“…In the analysed literature, the most frequently recurrent therapy was based on the use of topical corticosteroids [12-19, 22, 24, 25, 30-34], followed by photo-dynamic therapy [13,17,30,[32][33][34], then by treatment with calcineurin inhibitors, such as tacrolimus and pimecrolimus [15,16,26,27,31], and finally by topical therapy with curcumin gel [18,22,23]. We also observed the use of various other types of intervention, namely cryotherapy [12], ozone therapy [30], excisional surgery [11], inhibitors of neo-angiogenesis [24], tocopherol [21], hydroxychloroquine [10], chamomile [28], hyaluronic acid [29], and Gluscosides of Paeony Capsule (GPC) [25].…”

Section: Methodsmentioning

confidence: 99%

“…It should be noted that some studies also excluded smokers [11][12][13] or heavy drinkers of alcohol [11] and patients with genital or skin lichenoid lesions [14][15][16][17][18], or patients affected by other types of oral lesions, different from those caused by OLP [19][20][21]. Finally, all trials using curcumin excluded patients with a history of gastric or duodenal ulcers, due to the irritative effect of turmeric on gastro-intestinal mucosa, and patients undergoing orthodontic treatment [22,23].…”

Section: Exclusion Criteriamentioning

confidence: 99%

“…Curcumin is one of the three curcuminoids contained in Curcuma Longa, a plant often used in oriental medicine due to its well-known anti-inflammatory, antioxidant, biostimulant and anti-cancer properties [22,35]. Its anti-inflammatory activity is expressed by inhibiting arachidonic acid metabolism that reduces the synthesis of prostaglandins and leukotrienes; moreover, it can modulate the immune response by stimulating the activation of macrophages, T lymphocytes and natural killer lymphocytes [18]. The analysed studies show that there are no statistically significant differences between the use of a 5% curcumin oral paste and the use of topical triamcinolone [22].…”

Section: Curcuminmentioning

confidence: 99%

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Clinical Management of Oral Lichen Planus: A Systematic Review

Oberti

Lucchese

Petruzzi

et al. 2019

MRMC

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Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment. Materials and Methods:We searched and analyzed PubMed database for articles on OLP management. Only randomized controlled trials, comparing an active treatment with placebo, or between different active treatments, were considered in this systematic review. Only patients with symptomatic OLP were included and interventions of all types were considered (topical treatment, systemic drugs, non pharmacological intervention). Results:A total of 25 randomized controlled trials were examined and included in this review. Steroids are the most frequently employed drug in the treatment of OLP and their efficacy and safety are demonstrated. Also calcineurin inhibitors and photo-dynamic therapy are used in different studies for OLP management, with positive results. Conclusion:Topical steroids remain the first-line treatment for symptomatic OLP, however, many different pharmacological and non-pharmacological therapies would represent a valid alternative for its management, but, nowadays they require further investigations. atrophic-erosive type, but are rarely present in reticular forms [3].It is important to distinguish OLP from oral lichenoid lesions, which can be similar in appearance, but the latter represent a reaction to specific causal factors (e.g. dental materials, traumas, drugs) [5].Managing OLP is aimed at reducing symptoms and the manifestation of lesions, characterized by periods of exacerbation and quiescence. The first-line treatment is represented by the use of topical corticosteroids, although other effective therapies, like photodynamic therapy and the use of calcineurin inhibitors have recently been made available. MATERIALS AND METHODSWe examined the main publications related to OLP management, identified by searching the PubMed electronic database. We used the following search items: oral lichen planus, oral lichen planus management, oral lichen planus treatment, oral lichen planus therapy, randomized trial oral lichen planus, oral lichen planus placebo, oral lichen planus

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Exclusion Criteriamentioning

confidence: 99%

Section: Curcuminmentioning

confidence: 99%

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Clinical Management of Oral Lichen Planus: A Systematic Review

Oberti

Lucchese

Petruzzi

et al. 2019

MRMC

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Interventions for treating oral lichen planus: corticosteroid therapies

Lodi

Manfredi

Mercadante

et al. 2020

Cochrane Database of Systematic Reviews

100

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Background Oral lichen planus (OLP) is a relatively common chronic T cell-mediated disease, which can cause significant pain, particularly in its erosive or ulcerative forms. As pain is the indication for treatment of OLP, pain resolution is the primary outcome for this review. This review is an update of a version last published in 2011, but focuses on the evidence for corticosteroid treatment only. A second review considering non-corticosteroid treatments is in progress. Objectives To assess the e ects and safety of corticosteroids, in any formulation, for treating people with symptoms of oral lichen planus. Search methods Cochrane Oral Health's Information Specialist searched the following databases to 25 February 2019: Cochrane Oral Health's Trials Register, CENTRAL (2019, Issue 1), MEDLINE Ovid, and Embase Ovid. ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions on language or date of publication. Selection criteria We considered randomised controlled clinical trials (RCTs) of any local or systemic corticosteroid treatment compared with a placebo, a calcineurin inhibitor, another corticosteroid, any other local or systemic (or both) drug, or the same corticosteroid plus an adjunctive treatment. Data collection and analysis Three review authors independently scanned the titles and abstracts of all reports identified, and assessed risk of bias using the Cochrane tool and extracted data from included studies. For dichotomous outcomes, we expressed the estimates of e ects of an intervention as risk ratios (RR), with 95% confidence intervals (CI). For continuous outcomes, we used mean di erences (MD) and 95% CI. The statistical unit of analysis was the participant. We conducted meta-analyses only with studies of similar comparisons reporting the same outcome measures. We assessed the overall certainty of the evidence using GRADE. Main results We included 35 studies (1474 participants) in this review. We assessed seven studies at low risk of bias overall, 11 at unclear and the remaining 17 studies at high risk of bias. We present results for our main outcomes, pain and clinical resolution measured at the end of Interventions for treating oral lichen planus: corticosteroid therapies (Review)

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Herbal medicine in oral lichen planus

Ghahremanlo

Boroumand

Ghazvini

et al. 2018

Phytotherapy Research

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Oral lichen planus (OLP) is a common chronic inflammatory and T cell‐mediated autoimmune disease in which the oral mucosa, tongue, and gingiva are involved. Different treatments have been suggested to reduce the symptoms of this disease. Currently, a common treatment for OLP is the use of corticosteroids as the gold standard, although they have considerable side effects. The chronicity of the disease needs the long‐term use of these drugs with ensuing side effects. Therefore, various studies have been done to find an alternative and effective treatment. The use of herbal medicine as an alternative therapy with antioxidant and anti‐inflammatory properties seems promising. Hence, this review study was done to summarize the efficiency of different herbal medicine in the treatment of OLP.

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Evaluation of Efficacy of 1% Curcuminoids as Local Application in Management of Oral Lichen Planus – Interventional Study

Cited by 38 publications

References 21 publications

Clinical Management of Oral Lichen Planus: A Systematic Review

Clinical Management of Oral Lichen Planus: A Systematic Review

Interventions for treating oral lichen planus: corticosteroid therapies

Herbal medicine in oral lichen planus

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