Evaluation of gastroprotective activity and acute toxicity of<i>Solidago chilensis</i>Meyen (Asteraceae)

Bucciarelli, Alejandro; Minetti, Alejandra; Milczakowskyg, Cristina; Skliar, Mario

doi:10.3109/13880200903453131

Cited by 32 publications

(43 citation statements)

References 21 publications

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“…Its main chemical constituents are acetophenone, carotenes, diterpenoids with labdanic and clerodanic skeletons (Soares-Valverde et al, 2009), flavonoids, glycosides, 3-methoxybenzaldehyde, essential oils, and saponins (Silva et al, 2010), with quercetrin being the major constituent (Torres et al, 1987 Ethnopharmacological investigations have found this species to have antispasmodic, antihemorrhagic (Alonso, 1998), woundhealing (Facury-Neto et al, 2004, and anti-inflammatory effects (Tamura et al, 2009). Recently, there has been considerable progress in the investigation of S. chilensis and gastric protection (Bucciarelli et al, 2010) as well as a better understanding of the effect of S. chilensis on insulin resistance in obese mice (Melo et al, 2011). However, the hypoglycemic and hypolipidemic effects of S. chilensis on the glucose tolerance curve have not yet been studied.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Schneider

Sachett

Schönell

et al. 2015

Revista Brasileira de Farmacognosia

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a b s t r a c tSolidago chilensis Meyen, Asteraceae, is traditionally used to treat inflammation. However, phytochemical and pharmacology investigations are lacking. This study evaluated the hypoglycemic and hypolipidemic effects of hydroalcoholic extract from S. chilensis aerial parts in rats. In oral glucose tolerance tests the rats received saline (0.5 ml/100 g) in control group (C), hydroalcoholic extract (125, 250 or 500 mg/kg p.o.; n = 6) or glibenclamide (10 mg/kg p.o.; n = 6). After 30 min, glucose (4 g/kg) was administered. Rats treated with hydroalcoholic extract 500 demonstrated decreased glucose levels at 180 min (−22.1%), when compared with group C, similar to glibenclamide. Moreover, treatment with hydroalcoholic extract 500 significantly increased the glycogen content in the liver and soleus muscle, and hydroalcoholic extract 250 specifically inhibited the enzyme maltase when compared with group C. Furthermore, all hyperglycemic rats treated with hydroalcoholic extract (125, 250 and 500) exhibited an accentuated decrease in total cholesterol levels (−36.8%, −36.7% and −41.3%, respectively). Our results suggest that hypoglycemic and hypolipidemic effects of hydroalcoholic extract could be associated with increased production and release of insulin as well as with insulinotropic and antioxidant effects.

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Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Schneider

Sachett

Schönell

et al. 2015

Revista Brasileira de Farmacognosia

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“…The immediate cause of peptic ulcer is considered as the disturbance in the protection of stomach mucosa against gastric acid (Bucciarelli et al, 2010). Nowadays the risk of gastric attacks is significantly increased due to exposure of human to many noxious agents and chemicals (Chaturvedi et al, 2007) and it is estimated that nearly 20% of the world population suffer from peptic ulcer.…”

Section: Introductionmentioning

confidence: 99%

“…Meal-stimulated gastrin levels, decreased gastric mucus production and duodenal mucosal bicarbonate secretion are common with patients having Helicobacter pylori infection, all of which favor ulcer formation. Even though many synthetic drugs are available in the clinical practice, the researchers still in search of antiulcer compounds from natural resources (Bucciarelli et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action

Abdelwahab

Mohan

Abdulla

et al. 2011

Journal of Ethnopharmacology

114

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“…[21] However, genotoxicity could be an example of side effect caused by long term exposure to chemical agents. For example, no toxicity was observed in mice upon short-term oral administration of the S. chilensis aqueous extract.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba – Goldenrod

Woźniak

Ślusarczyk

Domaradzki

et al. 2018

Chemistry & Biodiversity

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European Pharmacopoeia accepts two equivalent species Solidago canadensis L. and S. gigantea Aiton as goldenrod (Solidaginis herba). We compared phytochemical profile of both species from invasive populations in Poland. Further, we compared in vitro antimutagenic and antioxidant activities of solvent extracts from aerial (AP) and underground parts (UP). In S. gigantea, flavonoid profile was dominated by quercetin glycosides, with quercitrin as the major compound. In S. canadensis, quercetin and kaempferol rutinosides were two major constituents. Caffeoylquinic acids (CQAs) were less diverse with 5-CQA as a main compound. In UP, over 20 putative diterpenoids were detected, mostly unidentified. Several CQAs were present in higher amounts than in AP. Antioxidant and antimutagenic activities were different between species and organs, with the strongest inhibition of lipid peroxidation by Et O and AcOEt fractions from AP of both species (IC 13.33 - 16.89 μg/mL) and BuOH fraction from S. gigantea UP (IC = 13.32 μg/mL). Chemical mutagenesis was completely inhibited by non-polar fractions, but oxidative mutagenesis was inhibited up to 35% only by S. canadensis. No clear relationship was found between chemical profiles and antimutagenic activity. In conclusion, both species have diverse activity and their phytochemical profiles should be considered in quality evaluation. UP of these weeds can also provide potential chemopreventive substances for further studies.

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Evaluation of gastroprotective activity and acute toxicity ofSolidago chilensisMeyen (Asteraceae)

Cited by 32 publications

References 21 publications

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action

Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba – Goldenrod

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