Evaluation of genotoxic and antioxidant activity of an Aesculus hippocastanum L. (Sapindaceae) phytotherapeutic agent

Felipe, Maria Beatriz Mesquita Cansanção; Carvalho, Fabíola Marques de; Félix-Silva, Juliana; Fernandes-Pedrosa, Matheus de Freitas; Scortecci, Kátia Castanho; Agnez-Lima, Lucymara Fassarella; Medeiros, Sílvia Regina Batistuzzo de

doi:10.1016/j.bionut.2012.10.014

Cited by 12 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Introductionmentioning

confidence: 99%

“…1 Its popularity is still maintained due to the cultural and historical reasons, and to the primary health care needs added by modern medicine. 1,2 For instance, beneficial effects including antimutagenicity, 3 chemoprotection, and antioxidant activity have been reported. 4 Aesculus hippocastanum L., commonly known as "horse chestnut", is a native, stable and important elements of urban and rural landscapes, which is widely distributed all over the world.…”

Section: Introductionmentioning

confidence: 99%

“…4 Aesculus hippocastanum L., commonly known as "horse chestnut", is a native, stable and important elements of urban and rural landscapes, which is widely distributed all over the world. 1,5 It is used for a variety medical conditions, including malary, fever, bladder and gastrointestinal disorders. Moreover, the seeds extract have been prescribed traditionally for the treatment of several chronic venous insufficiency, to reduce its associated symptoms, including leg swelling and heaviness as well as vascular problems.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of Four Major Saponins in Skin and Endosperm of Seeds of Horse Chestnut (Aesculus Hippocastanum L.) Using High Performance Liquid Chromatography with Positive Confirmation by Thin Layer Chromatography

Abudayeh¹,

Azzam²,

Naddaf³

et al. 2015

Adv Pharm Bull

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of Four Major Saponins in Skin and Endosperm of Seeds of Horse Chestnut (Aesculus Hippocastanum L.) Using High Performance Liquid Chromatography with Positive Confirmation by Thin Layer Chromatography

Abudayeh¹,

Azzam²,

Naddaf³

et al. 2015

Adv Pharm Bull

View full text Add to dashboard Cite

“…Na medicina, as sementes e casca de ramos jovens são utilizadas, sendo o extrato da semente amplamente divulgado como medicamento fitoterápico, recomendado para o tratamento de insuficiência venosa crônica, edema traumático, hemorroidas ou edema pós-operatório (12).…”

Section: Resultsunclassified

“…Para ser utilizada com fins terapêuticos, devem estar secas e maduras. A maior parte do efeito terapêutico dessa planta é devida à aescina, principal constituinte químico da espé-cie (12). A β-aescina é o principal constituinte, presente nas sementes, que pode ser detectada através da verificação da presença de saponinas triterpênicas (14).…”

Section: Resultsunclassified

Estudos Pré-Clínicos E Clínicos De Espécies Vegetais Selecionadas De Países Pertencentes Ao Mercosul E Aspectos Toxicológicos

Cechinel-Zanchett¹

2017

Infarma

View full text Add to dashboard Cite

Medicinal plants are used to prevent and treat diseases and have been used by about 80% of the population for primary health care. The rich biodiversity of Brazil and neighboring Countries offers a unique and unparalleled potential for the discovery and development of bioactive agents. This study aimed to do a review of preclinical and clinical studies of herbal and plant species selected from Mercosul countries, and toxicological aspects. Based on previous work, the species with the highesAt number of register in Brazil (Anvisa), Aesculus hippocastanum (Horse Chestnut) and Mikania glomerata (Guaco); the most used as simple herbal medicines in Argentina Cynara scolymus L. (Artichoke) and Solanum dulcamara (Dulcamara); the sold medicinal plants in Paraguay Peumus boldus Mol. (Bilberry), and Borago officinalis (Borage); the most consumed in northern Uruguay Aloe vera (Aloe) and Passiflora edulis (Passion flower) and from Venezuela, Hedera helix (Hera) were selected for a review about pharmacology studies. Surveys on pre-clinical and clinical trials of these species were conducted on Google Scholar, PubMed and Science Direct databases in April 2016, in Portuguese and English. Then the most relevant articles were selected, using animals (rats, rabbits or mice), cellular or bacterial strains or clinical trials. About preclinical and clinical studies, Aloe and Artichoke showed the most substantial number of publications.Keywords: phytotherapy; Mercosul; medicinal plants RESUMOAs plantas medicinais são utilizadas para a prevenção e tratamento de doenças, sendo usada por cerca de 80% da população para o cuidado primário à saúde. A rica biodiversidade do Brasil e países vizinhos oferece um potencial único e incomparável para a descoberta e desenvolvimento de agentes bioativos. O objetivo desse trabalho foi fazer uma revisão sobre estudos pré-clínicos e clínicos de espécies vegetais selecionadas dos países do Mercosul e aspectos toxicológicos. Com base em trabalho publicado anteriormente pelo autor, foram selecionadas as espécies com maior nú-mero de registro na Anvisa no Brasil (Aesculus hippocastanum -Castanha da Índia e Mikania glomerata-Guaco); as mais utilizadas como medicamentos fitoterápicos simples na Argentina (Cynara scolymus L. -Alcachofra e Solanum dulcamara -Dulcamara); as plantas medicinais mais vendidas no Paraguai (Peumus boldus Mol. -Boldo e Borago officinalis -Borragem); as mais consumidas no norte do Uruguai (Aloe vera -Aloe e Passiflora edulis -Maracujá) e da Venezuela a Hedera helix (Hera) por ser muito popular no país seu consumo. Foram realizadas pesquisas nas bases de dados Google Acadêmico, PubMed e Science Direct no mês de abril de 2016, sobre ensaios pré-clínicos e clínicos dessas espécies vegetais, em português e inglês, sendo selecionados os artigos mais relevantes, com uso de animais (ratos, coelhos ou camundongos), linhagens celulares ou bacterianas, ou estudos clínicos. Em relação aos estudos pré-clínicos e clínicos, Aloe e Alcachofra, foram as que apresentaram maior número de publi...

show abstract

Development of a photoprotective and antioxidant nanoemulsion containing chitosan as an agent for improving skin retention

Cerqueira-Coutinho

Santos-Oliveira

Santos

et al. 2015

Engineering in Life Sciences

View full text Add to dashboard Cite

Sunscreens are destined to topical application and should protect skin against ultraviolet radiation; furthermore, they are toxic substances and should not reach the bloodstream, so they must be retained in the skin. In the present work, an oil-inwater photoprotective and antioxidant nanoemulsion (NE) containing chitosan was developed. Preliminary studies were performed aiming to choose the surfactant to be used in this NE; stability of the formulas was determined by dynamic light scattering after their preparation and after 7 days. A blend of surfactants, polyoxyethylene sorbitan monooleate, and sorbitan monooleate was selected for the preparation of the NE, as well as the following organic sunscreens: benzophenone-3, diethylamino hydroxybenzoyl hexylbenzoate, octocrylene and octylmethoxycinnamate, and also pomegranate antioxidant extract and chitosan. The antioxidant extract with the highest antioxidant activity was chosen based on a screening of plant extracts by DPPH• (2,2-diphenyl-1-picrylhydrazyl) assay. Photostability of the sunscreens and in vitro efficacy and safety of the formulations were also evaluated. Results showed that the developed photoprotective and antioxidant NE containing chitosan was stable for at least 6 months, photostable when irradiated in a solar simulator, and effective. Additionally, chitosan acted by promoting retention of the formulation in epidermis, thus increasing formulation safety.

show abstract

Evaluation of genotoxic and antioxidant activity of an Aesculus hippocastanum L. (Sapindaceae) phytotherapeutic agent

Cited by 12 publications

References 42 publications

Determination of Four Major Saponins in Skin and Endosperm of Seeds of Horse Chestnut (Aesculus Hippocastanum L.) Using High Performance Liquid Chromatography with Positive Confirmation by Thin Layer Chromatography

Determination of Four Major Saponins in Skin and Endosperm of Seeds of Horse Chestnut (Aesculus Hippocastanum L.) Using High Performance Liquid Chromatography with Positive Confirmation by Thin Layer Chromatography

Estudos Pré-Clínicos E Clínicos De Espécies Vegetais Selecionadas De Países Pertencentes Ao Mercosul E Aspectos Toxicológicos

Development of a photoprotective and antioxidant nanoemulsion containing chitosan as an agent for improving skin retention

Contact Info

Product

Resources

About