Evaluation of hematological and biochemical parameters of pesticide retailers following occupational exposure to a mixture of pesticides

Neghab, Masoud; Jalilian, Hamed; Taheri, Shekoufeh; Tatar, Mohsen; Zadeh, Zeynab Haji

doi:10.1016/j.lfs.2018.04.020

Cited by 14 publications

(19 citation statements)

References 27 publications

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“…Efek utama keracunan pestisida adalah gangguan sistem saraf seperti sakit kepala, pusing, paresthesia, tremor, diskoordinasi, kejang; serta menghambat enzim asetylcholinesterase yang menggangu organ gerak. Dampak jangka panjang pestisida antara lain anemia, anoreksia, berkurangnya berat badan dan gangguan fungsi hati (Agustina & Norfai, 2018;Arwin & Suyud, 2016;Azmi, Naqvi, Azmi, & Aslam, 2006;Britt & Budinky A, 2000;Fauziyyah, Suhartono, & Astorina, 2017;Kartini et al, 2019;Nassar, Salim, & Malhat, 2016;Neghab, Jalilian, Taheri, Tatar, & Haji Zadeh, 2018;Okvitasari, Anwar, & Suparmin, 2016;Patil, Patil, & Govindwar, 2003;Prasetyaningsih, Arisandi, & Retnosetiawati, 2017;Sihana, Dawson, & Buckley, 2019).…”

Section: Penggunaanunclassified

Faktor Risiko Keracunan Pestisida Pada Petani Hortikultura Di Kabupaten Lampung Barat

Yushananta

Melinda

Mahendra

et al. 2020

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Pesticide poisoning is still an important health problem in agricultural areas, especially horticultural agriculture. Various chronic health effects can be caused by long-term exposure to pesticides. This study aims to determine the risk factor of pesticide poisoning in horticultural farmers in West Lampung Regency. The study used a cross sectional design which was conducted in four different areas as the center of horticulture agriculture, West Lampung Regency, Lampung Province. The study involved 289 participants by interviewing, observing and examining blood samples to measure cholinesterase levels as an indicator of pesticide poisoning. In this section, we have applied research ethical procedures. The obtained data were analyzed using Chi squre test, Odds Ratio test and Logistic Regression. The results showed that the risk factors for pesticide poisoning were incomplete use of personal protected equipment (PPE), spraying with the wrong dose and spraying frequency. Unwearing a complete PPE had a 4.54 times (OR = 4.54; 95% CI 2.09-9.83) higher risk of experiencing pesticide poisoning, and statistically suggested, a very significant relationship (p-value = 0.0001). While the use of excessive dosage has a risk of 4.39 times (OR = 4.39; 95% CI 1.87-10.33; p-value = 0.001); and the frequency of spraying more than twice a week had a 2.33 times higher risk of experiencing pesticide poisoning (OR = 2.33; 95% CI 1.24-4.40; p-value = 0.009). Excessive use of pesticide dosage and the frequency of spraying with the cover blanked method are the main factors of pesticide exposure to farmers. On the other hand, the use of PPE is a method of protection from exposure. It needs joint efforts through increasing knowledge about the dangers of pesticides, pesticide management, how to work safely, and the use of PPE.

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Section: Penggunaanunclassified

Faktor Risiko Keracunan Pestisida Pada Petani Hortikultura Di Kabupaten Lampung Barat

Yushananta

Melinda

Mahendra

et al. 2020

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“…A large body of evidence on workers who deal with pesticides has reported different health consequences including dermal 5 and respiratory problems, 6-8 hematological and biochemical impairments, 9,10 as well as coronary artery disease 11 and cancer 12,13 . Since 2009, a few studies on the health of pesticide retailers have suggested that exposure to active pesticide ingredients may induce different adverse health effects in this working community.…”

Section: Introductionmentioning

confidence: 99%

“…Since 2009, a few studies on the health of pesticide retailers have suggested that exposure to active pesticide ingredients may induce different adverse health effects in this working community. 9,14-16…”

Section: Introductionmentioning

confidence: 99%

Respiratory and Dermal Symptoms and Raised Serum Concentrations of Biomarkers of Oxidative Stress among Pesticide Retailers

Jalilian

Neghab

Tatar

et al. 2018

Int J Occup Environ Med

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Background: Recently concern has been raised regarding possible health effects resulting from exposure of a group of pesticide retailers to chemicals they handle. Objective: To investigate the prevalence of respiratory and dermal symptoms, as well as biomarkers of oxidative stress, among pesticide retailers and to compare them with those of an unexposed comparison group. Methods: 70 male pesticide retailers and 64 male construction workers (served as the comparison group) were investigated. Blood samples were taken from all participants to assess the biomarkers of oxidative stress. A data sheet and the European Community Respiratory Health Survey II questionnaire were used to determine the prevalence of dermal and respiratory disorders, respectively. Results: After adjusting for age, weight, height, education level, job tenure, average daily work, presence of family history of respiratory diseases, marital status, smoking status, and number of cigarettes smoked per day, we found that wheezing (OR 4.07, 95% CI 1.17 to 14.17), cough (OR 3.38, 95% CI 1.15 to 9.98), and mucus hypersecretion (OR 3.66, 95% CI 1.45 to 9.05) were significantly more prevalent among pesticide retailers compared with the comparison group. The prevalence of tingling and dryness of skin exposed individuals was significantly higher than unexposed participants. The mean serum concentrations of glutathione and malondialdehyde in the exposed group were significantly higher than those in the comparison group. Conclusion: Occupational exposure to low doses of a mixture of pesticides by retailers was associated with increased prevalence of dermal and respiratory symptoms as well as raised concentrations of biomarkers of oxidative stress.

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“…Contrary to Binukumar’s study, Aroonvilairat et al reported that primary signs of the kidney function (creatinine) and liver function (AST, ALT) did not show difference between healthy and organophosphate exposed groups, and their levels were within the normal range of reference values in a pesticide study in farmers [55]. Furthermore, Neghab et al did not find any significant difference for the kidney function status (BUN, creatinine) and liver enzyme (ALT and AST) between pesticide retailers and workers [56]. Herein, we did not observe significant changes for several biochemical parameters (ALT, AST, creatinine, ureas, glucose and calcium).…”

Section: Discussionmentioning

confidence: 99%

Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure

et al. 2019

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Evaluation of hematological and biochemical parameters of pesticide retailers following occupational exposure to a mixture of pesticides

Cited by 14 publications

References 27 publications

Faktor Risiko Keracunan Pestisida Pada Petani Hortikultura Di Kabupaten Lampung Barat

Faktor Risiko Keracunan Pestisida Pada Petani Hortikultura Di Kabupaten Lampung Barat

Respiratory and Dermal Symptoms and Raised Serum Concentrations of Biomarkers of Oxidative Stress among Pesticide Retailers

Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure

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