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Background: Recently concern has been raised regarding possible health effects resulting from exposure of a group of pesticide retailers to chemicals they handle. Objective: To investigate the prevalence of respiratory and dermal symptoms, as well as biomarkers of oxidative stress, among pesticide retailers and to compare them with those of an unexposed comparison group. Methods: 70 male pesticide retailers and 64 male construction workers (served as the comparison group) were investigated. Blood samples were taken from all participants to assess the biomarkers of oxidative stress. A data sheet and the European Community Respiratory Health Survey II questionnaire were used to determine the prevalence of dermal and respiratory disorders, respectively. Results: After adjusting for age, weight, height, education level, job tenure, average daily work, presence of family history of respiratory diseases, marital status, smoking status, and number of cigarettes smoked per day, we found that wheezing (OR 4.07, 95% CI 1.17 to 14.17), cough (OR 3.38, 95% CI 1.15 to 9.98), and mucus hypersecretion (OR 3.66, 95% CI 1.45 to 9.05) were significantly more prevalent among pesticide retailers compared with the comparison group. The prevalence of tingling and dryness of skin exposed individuals was significantly higher than unexposed participants. The mean serum concentrations of glutathione and malondialdehyde in the exposed group were significantly higher than those in the comparison group. Conclusion: Occupational exposure to low doses of a mixture of pesticides by retailers was associated with increased prevalence of dermal and respiratory symptoms as well as raised concentrations of biomarkers of oxidative stress.

The mechanism by which granulocyte colony-stimulating factor (G-CSF) could lead to the protection from liver injury is not well known. Therefore, the resolution of this role needs further basic and clinical experimental investigation. Acute liver injury was induced in rats by single intraperitoneal injection of a 0.50-mL/kg dose of carbon tetrachloride (CCl4 ). Granulocyte colony-stimulating factor or vehicle of 150 µg/kg was given immediately after intoxicating the liver by CCl4 . The animals were divided into four groups of twelve each. Administration of G-CSF caused a decrease in the activity of liver enzymes,  aminotransferases, compared with the untreated group.