Evaluation of hepatotoxicity effect of methanol leave extract of Gongronema latifolium in Albino rats

Abstract

Gongronema latifolium is highly medicinal in nature. The fundamental ingredients used for medicinal purposes are stored in the various parts of the plant such as the fruits, seeds, leaves, root and stem. This present study is aimed to evaluate the hepatotoxicity effect of methanolic leaf extract of Gongronema latifolium on albino rats. This study was divided into five groups normal control groups: received commercial rat feed and water, group 2: received 1000 mg/kg b.w. of leaf extract of Gongronema latifolium, group 3: received 500 mg/kg b.w of leaf extract of G. latifolium, group 4; received 250 mg/kg of leaf extract of Gongronema latifolium, and group 5: received 125mg/kg of leaf extract of Gongronema latifolium. The result shows a significant (p<0.05) increase in serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total and conjugate bilirubin when compared to the normal control not giving the extract. Administration graded dosage of 1000mg/kg and 500mg/kg body weight significantly (p<0.05) increased the liver damage marker enzymes when compared with groups that received low dosage of 250mg/kg and 125mg/kg body weight and the normal control groups. The histopathological study revealed severe portal inflammation without steatosis and moderate portal inflammation in groups that received 1000mg/kg and 500mg/kg. Therefore, these results suggested that methanol leaf extracts of Gongronema latifolium possess hepatotoxic properties and strict caution must be observed when using the plant extract as a natural remedy of any disease.

Gongronema latifolium Ethanol Crude Leaf Extract Ameliorates Organ Injuries Via Anti-Inflammatory and Anti-Diabetic Mechanisms in Streptozotocin-Induced Diabetic Rats

“…4 Previous investigations claimed that Gongronema latifolium leaf extracts in methanol have hepatotoxic effects, hence extreme caution must be used while taking the plant's extract as a natural treatment for any condition. 32 Histological effects of Gongronema latifolium on the kidney The kidney of the control group displayed normal renal tubules and glomeruli. Normal cellular mesangial and Bowman space were features of the glomeruli.…”

Epigenetics and mitochondrial dysfunction insights into the impact of the progression of non‐alcoholic fatty liver disease

“…It is possible to revert to a healthy liver unless steatohepatitis sets in, but once cirrhosis sets in, it is fatal. As hepatocytes get damaged, blood levels of liver enzymes such as aspartate transaminase and alanine transaminase rise 8 . In addition to metabolic imbalance, researchers have discovered that DNA methylation, histone modification, and noncoding RNAs all play a role in NAFLD.…”

“…As hepatocytes get damaged, blood levels of liver enzymes such as aspartate transaminase and alanine transaminase rise. 8 In addition to metabolic imbalance, researchers have discovered that DNA methylation, histone modification, and noncoding RNAs all play a role in NAFLD. Mitochondria, which mediates the metabolism of carbohydrates, lipids, and fat, have been detected in significant masses in the liver and have some distinct characteristics.…”