Evaluation of Hesperidin Protective Effect on Lipopolysaccharide-Induced Inflammation and lipid Peroxidation in BALB/C Mail Mice

Al-Rikabi, Rasha H.; Al-Shmgani, Hanady S.

doi:10.5958/0974-360x.2018.01003.x

Rese. Jour. of Pharm. and Technol.

2018

DOI: 10.5958/0974-360x.2018.01003.x

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Evaluation of Hesperidin Protective Effect on Lipopolysaccharide-Induced Inflammation and lipid Peroxidation in BALB/C Mail Mice

Rasha H. Al-Rikabi¹,

Hanady S. Al-Shmgani²

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Cited by 5 publications

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Investigation of Antibacterial Activity and Wound Healing Promotion Properties Induced by Bromelain-Loaded Silver Nanoparticles

Ashij,

Al-Shmgani,

Sulaiman

et al. 2023

Plasmonics

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Investigation of Antibacterial Activity and Wound Healing Promotion Properties Induced by Bromelain-Loaded Silver Nanoparticles

Ashij,

Al-Shmgani,

Sulaiman

et al. 2023

Plasmonics

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Immobilization of Bromelain on Gold Nanoparticles for Comprehensive Detection of Their Antioxidant, Anti-Angiogenic, and Wound-Healing Potentials

Ausaj,

Al-Shmgani,

Abid

et al. 2024

Inorganics

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Bromelain (Br) is a proteolytic enzyme with various pharmacological properties, such as antibacterial, antioxidant, anti-inflammatory, anticancer, and anti-angiogenic properties. However, due to its low solubility and bioavailability, its absorption is low, so a delivery mechanism is needed to achieve the desired therapeutic effects. Bromelain was chemically synthesized and loaded onto gold nanoparticles (AuNPs). Different methods and techniques were used for detection and characterization, including color-change detection, UV spectroscopy, XRD, SEM, TEM, and FTIR. The in vitro antioxidant activity was detected using DPPH assays, and the wound-healing activity was investigated in mice. The current study revealed that the formulated AuNPs-Br showed effective antioxidant activity and the strongest wound-healing properties, as demonstrated by histopathological and in vivo studies, and showed anti-angiogenic effects.

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In Vivo and In Vitro Evaluation of the Protective Effects of Hesperidin in Lipopolysaccharide-Induced Inflammation and Cytotoxicity of Cell

et al. 2020

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(1) Background: Plant flavonoids are efficient in preventing and treating various diseases. This study aimed to evaluate the ability of hesperidin, a flavonoid found in citrus fruits, in inhibiting lipopolysaccharide (LPS) induced inflammation, which induced lethal toxicity in vivo, and to evaluate its importance as an antitumor agent in breast cancer. The in vivo experiments revealed the protective effects of hesperidin against the negative LPS effects on the liver and spleen of male mice. (2) Methods: In the liver, the antioxidant activity was measured by estimating the concentration of glutathione (GSH) and catalase (CAT), whereas in spleen, the concentration of cytokines including IL-33 and TNF-α was measured. The in vitro experiments including MTT assay, clonogenity test, and sulforhodamine 101 stain with DAPI (4′, 6-diamidino-2-phenylindole) were used to assess the morphological apoptosis in breast cancer cells. (3) Results: The results of this study revealed a significant increase in the IL-33 and TNF-α cytokine levels in LPS challenged mice along with a considerable elevation in glutathione (GSH); moreover, the catalase (CAT) level was higher compared to that of the control group. Cytotoxicity of the MCF-7 cell line revealed significant differences among the groups treated with different concentrations when compared to the control groups, in a concentration-dependent manner. Hesperidin significantly inhibited the colony formation of MCF7 cells when compared to that of control. Clear changes were observed in the cell shape, including cell shrinkage and chromatin condensation, which were associated with a later apoptotic stage. (4) Conclusion: The results indicate that hesperidin might be a potential candidate in preventing diseases.

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Evaluation of Hesperidin Protective Effect on Lipopolysaccharide-Induced Inflammation and lipid Peroxidation in BALB/C Mail Mice

Cited by 5 publications

References 0 publications

Investigation of Antibacterial Activity and Wound Healing Promotion Properties Induced by Bromelain-Loaded Silver Nanoparticles

Investigation of Antibacterial Activity and Wound Healing Promotion Properties Induced by Bromelain-Loaded Silver Nanoparticles

Immobilization of Bromelain on Gold Nanoparticles for Comprehensive Detection of Their Antioxidant, Anti-Angiogenic, and Wound-Healing Potentials

In Vivo and In Vitro Evaluation of the Protective Effects of Hesperidin in Lipopolysaccharide-Induced Inflammation and Cytotoxicity of Cell

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