Evaluation of hs-CRP, antioxidant markers and MDA in patients of Coronary Artery Disease (CAD) containing Non-Smokers and Non-Diabetics

Khaki, Khatibi Fatemeh; Yaghoubi, Ali; Zarghami, N.; Rahbani, Mohamad

doi:10.1016/j.clinbiochem.2011.08.384

Cited by 3 publications

(5 citation statements)

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“…This reduced NO generation eventually led to endothelial dysfunction. A connection was demonstrated between Arginase activity and endothelial dysfunction in experimental models of some cases including diabetes [19], [20], aging [21], hypertension [13], pulmonary hypertension [22], and atherosclerosis [23]. Additionally, rabbits with hyperlipidemia who developed atheromatous lesions showed elevated Arginase activity [24].…”

Section: Discussionmentioning

confidence: 98%

“…Additionally, rabbits with hyperlipidemia who developed atheromatous lesions showed elevated Arginase activity [24]. In apoE-/atherosclerotic mice, Arginase II is thought to be the dominant isoform of Arginase [25], [20], [26]. Furthermore, Arginase 1 has shown that the impact of cardiac damage in wild mice following AMI by suppressing NO production and enhancing the concentration of inflammatory cells in infarcted regions [27].…”

Section: Discussionmentioning

confidence: 99%

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Study of the Arginase Activity and Other Biochemical Parameters in Patients with Coronary Artery Disease in Baghdad Governorate-Iraq

Hussain

Muftin

Al-jibouri

et al. 2023

Al-Mustansiriyah Journal of Science

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The most prevalent form of heart disease and the main cause of death in both developed and developing nations is CAD. It happens when "plaque," or cholesterol or other fatty deposits that accumulate on the inner wall of the artery, narrows or blocks the arteries that deliver blood to the heart. Over time, chest pain might develop as a result of the reduction in blood flow to the heart caused by this plaque accumulation. The study was designed to find if Arginase acts as a biomarker for diagnosing Coronary Artery Disease (CAD). A total of 90 individual samples were included in the present study, the control group consist of 40 healthy individual samples, while the CAD patients were 50 individual samples. Some biochemical parameters such as fasting blood glucose (FBG), troponin I(TnI), high sensitivity C-reactive protein (hs-CRP), lipid profile, lactate dehydrogenase (LDH), and Arginase activity were analyzed. The results of the current study showed no significant differences in the average age of patients (67.00±6.78) when compared with the control group (61.10±6.46), P>0.05. A significant increase Was found in the FBI level, cholesterol, triglycerides, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), TnI, hs-CRP, LDH, and Arginase activity in the patient's group when compared with the control group. While significant decrease (P<0.05) was revealed in the high-density lipoprotein (HDL) level in CAD patients in comparison to the control group. Also, there was a positive significant correlation between Arginase activity with each age and FBG. As for the ROC operator curve for Arginase, it was found that the area under the curve (AUC) was 0.953 with a sensitivity of 90%, and specificity of 95%. The results in the present study indicate a possible use of Arginase as a diagnostic marker for CAD.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Study of the Arginase Activity and Other Biochemical Parameters in Patients with Coronary Artery Disease in Baghdad Governorate-Iraq

Hussain

Muftin

Al-jibouri

et al. 2023

Al-Mustansiriyah Journal of Science

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“…Atherosclerosis is the underlying disease process that may result in atherosclerotic CVD (ASCVD) including myocardial infarction, ischaemic stroke and peripheral arterial disease [4] .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…It has been estimated that men with the MetS have a 3-fold increased risk of CVD (3) . Atherosclerosis is the underlying disease process that may result in atherosclerotic CVD (ASCVD) including myocardial infarction, ischaemic stroke and peripheral arterial disease (4) .…”

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confidence: 99%

Dietary patterns and their associations with the metabolic syndrome and predicted 10-year risk of CVD in northwest Chinese adults

et al. 2020

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The diet impact on metabolic syndrome(MetS) and cardiovascular diseases has been investigated widely, but few studies investigated the association between dietary patterns(DPs) and the the predicted cardiovascular disease, derived from reduced-rank regression (RRR). The objectives of this study were to derive DPs using RRR and principal component analysis (PCA), and investigate their associations with MetS and estimated 10-year atherosclerotic cardiovascular disease (ASCVD). We used the baseline dataset from the Xinjiang multi-ethnic cohort study in China, collected from June 2018 to may 2019. A total of 14982 subjects aged 35-74 years from Urumqi, Huo Cheng, and Mo Yu were included in the analysis. The 10-year ASCVD risk was estimated using the Chinse ASCVD risk equations. The associations of DPs with MetS and 10-year ASCVD were determined using multivariable logistic regression models. In Urumqi and Mo yu, the increased RRR DP score was associated with a higher odds ratio (OR) of having the MetS and with a higher OR of elevated 10-year ASCVD risk. However, Only the first DP determined by PCA in Urumqi were inversely associated with MetS and elevated 10-year ASCVD risk. The prevalence of MetS and elevated ASCVD risk in urban population is higher than that in rural areas. Our results may help nutritionists develop more targeted dietary strategies to prevent MetS and ASCVD in different regions in China.

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“…Overweight and obesity are the fifth leading risk for global deaths (Lemoine et al, 2013). At least 2.8 million adults die each year as a result of obesity (Hardeman et al, 2000; Khatibi et al, 2013; Organization, 2016).…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of circulating macrophage inhibitory cytokine 1-growth differentiation factor 15 (MIC-1/GDF15) in obesity: Relation with vascular endothelial growth factor (VEGF) and markers of oxidative stress

et al. 2022

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Background: Macrophage inhibitory cytokine 1-Growth differentiation Factor 15 (MIC-1/GDF15) and vascular endothelial growth factor (VEGF) are novel regulators of obesity and energy homeostasis and food intake. Aims: In the current cross-sectional study, we aimed to evaluate MIC-1 and VEGF concentrations and their association with serum lipids and biomarkers of oxidative stress in obese individuals. Methods: Fifty six obese subjects, aged between 20–50 years old, participated in the current study. Anthropometric and nutritional parameters were assessed and serum and blood concentrations of MIC-1/GDF15, VEGF, markers of oxidative stress and serum lipids were evaluated. Results: Serum VEGF was strongly associated with serum lipids and MIC-1/GDF15 concentrations while serum MIC-1/GDF15 was associated with total cholesterol (TC) and VEGF levels. In multivariate regression analysis, serum VEGF, appetite and GPX were potent determinants of MIC-1/GDF15 concentrations while VEGF was only associated with serum MIC-1/GDF15. Conclusion: The findings of the current study demonstrated the association between MIC-1/GDF15 and VEGF. Moreover, a positive association between these cytokines and serum lipids, was also observed. The results suggest that MIC-1/GDF15 and VEGF might be considered as prognostic markers in obesity-related metabolic disorders. Although further mechanistic studies are needed to better clarify the underlying mechanism.

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Evaluation of hs-CRP, antioxidant markers and MDA in patients of Coronary Artery Disease (CAD) containing Non-Smokers and Non-Diabetics

Cited by 3 publications

References 0 publications

Study of the Arginase Activity and Other Biochemical Parameters in Patients with Coronary Artery Disease in Baghdad Governorate-Iraq

Study of the Arginase Activity and Other Biochemical Parameters in Patients with Coronary Artery Disease in Baghdad Governorate-Iraq

Dietary patterns and their associations with the metabolic syndrome and predicted 10-year risk of CVD in northwest Chinese adults

Prognostic value of circulating macrophage inhibitory cytokine 1-growth differentiation factor 15 (MIC-1/GDF15) in obesity: Relation with vascular endothelial growth factor (VEGF) and markers of oxidative stress

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