“…In comparison with this study, Damin et al (2007), Chen et al (2012) and Burnett-Hartman et al (2013) found HPV-16 as the most frequently detected HPV type in patients with CRC. Therefore, this study supports the hypothesis that expresses the different frequency patterns of HPV infection according to geographical variations and ethnicity of the populations (Jung et al, 2004;Chansaenroj According to Table 3, analysis of medical data in infected patients with CRC in compare to non-infected patients with CRC explained a possible association between high-risk types of HPV infections and accession Gillison and shah (2003), Chen et al (2012), Hamid and Mustafa (2012), Ghasemian et al (2013), Zandberg et al (2013) in comparison with results from Motlagh et al (2007), Giuliani et al (2008) investigate the ability of HPV infection to induce advanced stages of cancer in different malignancies. Furthermore, this study highlights the impact of high-risk types of HPV infection in distant metastasis and malignant lymph nodes invasion in compare with non-infected patients, which have been previously reported in several investigations (Chen et al, 1993;Gillison and shah, 2003;Bognar et al, 2008;McHugh et al, 2009;Zandberg et al, 2013).…”