Evaluation of Hyaluronic Acid/Agarose Hydrogel for Cartilage Tissue Engineering Biomaterial

Choi, Joo Hee; Kim, Jin Su; Kim, Won Kyung; Lee, Wonchan; Kim, Namyeong; Song, Cheol Ui; Jung, Jun Jae; Song, Jeong Eun; Khang, Gilson

doi:10.1007/s13233-020-8137-6

Cited by 24 publications

(14 citation statements)

References 49 publications

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“…Hyaluronic acid (HyA) is a natural linear polysaccharide, being naturally present and abundant in all biologic fluids of some bacteria and all vertebrates [ 2 , 3 , 4 ]. Due to its biocompatibility, biodegradability and presence in the native extracellular matrix of tissues [ 5 ], HyA has been extensively applied for medical [ 6 , 7 ] and biomedical applications [ 8 , 9 ], including drug delivery [ 10 , 11 , 12 ], bioprinting [ 13 ] and tissue engineering [ 14 ], cosmetics [ 15 ] and wastewater treatment [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Musilová

Mráček

Kašpárková

et al. 2021

IJMS

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Tracer diffusion coefficients obtained from the Taylor dispersion technique at 25.0 °C were measured to study the influence of sodium, ammonium and magnesium salts at 0.01 and 0.1 mol dm−3 on the transport behavior of sodium hyaluronate (NaHy, 0.1%). The selection of these salts was based on their position in Hofmeister series, which describe the specific influence of different ions (cations and anions) on some physicochemical properties of a system that can be interpreted as a salting-in or salting-out effect. In our case, in general, an increase in the ionic strength (i.e., concentrations at 0.01 mol dm−3) led to a significant decrease in the limiting diffusion coefficient of the NaHy 0.1%, indicating, in those circumstances, the presence of salting-in effects. However, the opposite effect (salting-out) was verified with the increase in concentration of some salts, mainly for NH4SCN at 0.1 mol dm−3. In this particular salt, the cation is weakly hydrated and, consequently, its presence does not favor interactions between NaHy and water molecules, promoting, in those circumstances, less resistance to the movement of NaHy and thus to the increase of its diffusion (19%). These data, complemented by viscosity measurements, permit us to have a better understanding about the effect of these salts on the transport behaviour of NaHy.

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Section: Introductionmentioning

confidence: 99%

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Musilová

Mráček

Kašpárková

et al. 2021

IJMS

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“…This feature can be used for the precise design of a material for a given biomedical task. For instance, agarose gels are considered prospective biomaterials for the regeneration of cartilage and brain implants ( Lecomte et al, 2018 ; Choi et al, 2020 ; Salati et al, 2020 ). Being in contact with tissues, agarose hydrogels undergo bioresorption ( Rousselle et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Dendriplex-Impregnated Hydrogels With Programmed Release Rate

et al. 2022

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Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA–dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.

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“…Therefore, HA was combined with other polysaccharides or proteins to form copolymer hydrogels for CTE. Successfully used composite hydrogels include a chitosan–HA hydrogel [ 80 ], a chitosan–HA-based biomimetic matrices [ 74 ], HA–agarose Hydrogel [ 79 ] and fibrin–HA hydrogel [ 105 ]. The addition of hyaluronic acid to polysaccharide-based ion complexes improves the ability of the complexes to form stable hydrogels.…”

Section: 3d Printing Of Hydrogels In Ctementioning

confidence: 99%

Recent Advancements in 3D Printing of Polysaccharide Hydrogels in Cartilage Tissue Engineering

et al. 2021

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The application of hydrogels coupled with 3-dimensional (3D) printing technologies represents a modern concept in scaffold development in cartilage tissue engineering (CTE). Hydrogels based on natural biomaterials are extensively used for this purpose. This is mainly due to their excellent biocompatibility, inherent bioactivity, and special microstructure that supports tissue regeneration. The use of natural biomaterials, especially polysaccharides and proteins, represents an attractive strategy towards scaffold formation as they mimic the structure of extracellular matrix (ECM) and guide cell growth, proliferation, and phenotype preservation. Polysaccharide-based hydrogels, such as alginate, agarose, chitosan, cellulose, hyaluronan, and dextran, are distinctive scaffold materials with advantageous properties, low cytotoxicity, and tunable functionality. These superior properties can be further complemented with various proteins (e.g., collagen, gelatin, fibroin), forming novel base formulations termed “proteo-saccharides” to improve the scaffold’s physiological signaling and mechanical strength. This review highlights the significance of 3D bioprinted scaffolds of natural-based hydrogels used in CTE. Further, the printability and bioink formation of the proteo-saccharides-based hydrogels have also been discussed, including the possible clinical translation of such materials.

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Evaluation of Hyaluronic Acid/Agarose Hydrogel for Cartilage Tissue Engineering Biomaterial

Cited by 24 publications

References 49 publications

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Dendriplex-Impregnated Hydrogels With Programmed Release Rate

Recent Advancements in 3D Printing of Polysaccharide Hydrogels in Cartilage Tissue Engineering

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