Evaluation of Immunomodulatory Activity of Clerodendrum phlomidis and Premna integrifolia Root

Gokani, Rina H.; Lahiri, Suman K.; Santani, D. D.; Shah, Mamta B.

doi:10.3923/ijp.2007.352.356

Cited by 18 publications

(2 citation statements)

References 11 publications

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“…Then 3 mL of distilled water was added to 20 µL of blood to lyse the erythrocytes. At the end, absorbance of the mixed solution (20 µL blood in 3 mL distilled water) was measured using a Shimadzu UV-1700 double beam spectrophotometer (Japan) at 650 nm (9). The carbon clearance rate was expressed relative to the control at respective points of time.…”

Section: Selected Pharmacological Testsmentioning

confidence: 99%

Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro

Roy¹,

Ray²

2009

Acta Pharmaceutica

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In immunotherapeutic research, over the last two decades, very intensive investigations were carried out of the preparation, experimental and clinical characteristics of a relatively new category of active substances, the so-called immunostimulants. They are products of natural or synthetic origin with different chemical characteristics and mechanisms of action (1). Such an immunostimulating drug is Sterodin ® . It is the proprietary name of the medicine produced from bile lipids and bacterial metabolites from Staphylococcus albus, Micrococcus catarrhal, E. coli, Paratyphoid A and B, Staphylococcus aureus, etc. Each strain has a definite number of cells in each mL of solution. Sterodin ® has been claimed to possess a non-specific immunopotentiating activity, particularly in infectious diseases. However, the mechanism of action and the exact parameters that are influenced by Sterodin ® are still unknown. Therefore, we performed some toxicological and pharmacological evaluations to get some basic data about Sterodin ® . Sterodin ® is a novel non-specific immunostimulating drug produced by a combination of bile lipids and bacterial metabolites. In the present study, we investigated some of its (i) toxicological and (ii) pharmacological properties in vivo, and (iii) drug-lipid interaction (lipid peroxidation) in vitro. We also evaluated the possible (iv) Sterodin ® -induced lipid peroxidation as well as the effect of ascorbic acid on this peroxidation. We found LD 50 of Sterodin ® to be 31.50 mL kg -1 body mass. In male albino mice, Sterodin ® increased the total white blood cells and neutrophils count by 59 and 26 %, respectively, on the 6 th day, compared to day 0 after injection and stimulated phagocytic activity in vivo. We used goat liver as lipid source in drug-lipid interaction studies in vitro. Our experiments show that Sterodin ® induces lipid peroxidation, which was prevented by ascorbic acid.

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Section: Selected Pharmacological Testsmentioning

confidence: 99%

Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro

Roy¹,

Ray²

2009

Acta Pharmaceutica

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“…The roots are used in the treatment of polyuria, cardiac diseases, oedema and diabetes. 7,8 The plant has been reported for anti-inflammatory 9,10 (leaf, aerial parts, root bark), antidiabetic 11 (stem), hepatoprotective 12 (whole plant), anti-arthritic 13 (leaves), antifungal 14 (leaves and stem), anti fertility 15 (root), immunomodulatory 16 (root) and anti-diarrhoeal 17 (leaves) activity. Several phytoconstituents have been reported in different parts of the plant particularly in roots ß-sitosterol, ceryl alcohol, clerodin, clerosterol and clerodendrin A were reported 18 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and in Vitro Thrombolytic Activity of Clerodendrum Phlomidis Roots

Gowri¹,

Shanbhag²,

Murali³

et al. 2018

Int. Res. J. Pharm.

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The aim of the present study is to evaluate the thrombolytic activity of aqueous and ethanol extracts of Clerodendrum phlomidis roots. The activity was assessed by thrombolytic assay (clot lysis) using streptokinase as standard. The preliminary phytochemical screening revealed the presence of carbohydrates, glycosides, phenolic compounds like tannins and flavonoids. Aqueous and ethanol extracts showed 48.53 % and 30.13 % clot lysis respectively while the standard (streptokinase) showed 50.74 % clot lysis. Aqueous extract at 20 mg/ml dose level showed significant (***P < 0.001) clot lysis when compared to control. The result indicates that aqueous extract has better thrombolytic activity compared to ethanol extract.

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Fortified Foods and Medicinal Plants as Immunomodulators

Abdel-Aziz

Aeron

Garg

2016

Microbes in Food and Health

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Evaluation of Immunomodulatory Activity of Clerodendrum phlomidis and Premna integrifolia Root

Cited by 18 publications

References 11 publications

Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro

Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro

Phytochemical Screening and in Vitro Thrombolytic Activity of Clerodendrum Phlomidis Roots

Fortified Foods and Medicinal Plants as Immunomodulators

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