Evaluation of immunoreactivity of in vitro and in vivo models against bacterial synthesized cellulose to be used as a prosthetic biomaterial

Kim, Gun Dong; Yang, Hana; Park, Hye Rim; Park, Cheung Seog; Park, Yong Seek; Lee, Seung Eun

doi:10.1007/s13206-013-7302-9

Cited by 42 publications

(23 citation statements)

References 39 publications

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“…Exposure of murine macrophages to BC-DETC did not result in cytotoxicity, at the concentrations of 3.5 and 35 μg/cm 2 corroborating earlier findings293031 and supporting the biocompatibility of BC. Macrophages infected with L. braziliensis and exposed to BC-DETC displayed a significantly decreased infection rate, which was associated with down regulated SOD activity and increased superoxide levels.…”

Section: Discussionsupporting

confidence: 87%

DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis

Celes

Trovatti

Khouri

et al. 2016

Sci Rep

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The treatment of leishmaniasis still relies on drugs with potentially serious adverse effects. Herein, we tested a topical formulation of bacterial cellulose (BC) membranes containing Diethyldithiocarbamate (DETC), a superoxide dismutase 1 inhibitor. Leishmania-infected macrophages exposed to BC-DETC resulted in parasite killing, without pronounced toxic effects to host cells. This outcome was associated with lower SOD1 activity and higher production of superoxide and cytokine mediators. Topical application of BC-DETC significantly decreased lesion size, parasite load and the inflammatory response at the infection site, as well as the production of both IFN-γ and TNF. Combination of topical BC-DETC plus intraperitoneal Sbv also significantly reduced disease development and parasite load. The leishmanicidal effect of BC-DETC was extended to human macrophages infected with L. braziliensis, highlighting the feasibility of BC-DETC as a topical formulation for chemotherapy of cutaneous leishmaniasis caused by L. braziliensis.

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Section: Discussionsupporting

confidence: 87%

DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis

Celes

Trovatti

Khouri

et al. 2016

Sci Rep

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“…It was also suggested that mechanical clearance would be the primary mechanism for lung clearance of cellulose materials [67]. BC is commonly regarded as one of the most biocompatible material in the family of nanocellulose and these claims were supported with evidence from the evaluation on osteoblast cells, endothelial cells, and mouse feeding experiment [68][69][70]. Although all from of nanocellulose can considerably be regarded as safe, further investigation on the mechanism of nanocellulose aggregation in the body and long-term evaluation of in vivo toxicity are very much required.…”

Section: Nanocellulose As Medical Devicesmentioning

confidence: 94%

Nanocellulose: Insight into Health and Medical Applications

Halib¹,

Ahmad²

2017

Handbook of Ecomaterials

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Discovering biomaterials of renewable and sustainable has become primary goal among researchers as a way to mitigate environmental impact. One of those abundantly present is cellulosic materials. Agricultural waste such as banana rachis, wheat straw, cassava bagasse, and coconut husk have been identified as a reliable resources in the production of cellulose fibers, a natural fillers for composite applications. Due to its high strength and stiffness, biodegradable, and biocompatible, this material has found its way in health and medical applications. Crystalline nanocellulose offers several advantages as pharmaceutical excipient that favors the extended and control release of the drugs. Whereas cellulose fiber has been incorporated and used as reinforce material for various

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“…Other studies on BASYC ® tube prosthesis found that the implanted BASYC ® tube completely incorporated with the carotid artery and interlaced with connective tissue . Furthermore, our previous studies have shown that BC is capable of being used as an ideal biomaterial for artificial blood vessels owing to its nontoxicity and nonimmunogenicity . However, under conditions of immune activation by microbial and periprosthetic infections or chronic inflammation, the relative effect of leukocytes on artificial prosthetic biomaterial, such as BC, has not been identified.…”

Section: Introductionmentioning

confidence: 97%

“…15 Furthermore, our previous studies have shown that BC is capable of being used as an ideal biomaterial for artificial blood vessels owing to its nontoxicity and nonimmunogenicity. 16 However, under conditions of immune activation by microbial and periprosthetic infections or chronic inflammation, the relative effect of leukocytes on artificial prosthetic biomaterial, such as BC, has not been identified. 17 PMN recruitment plays a critical role in the regulation of immune response; the early rate-limiting response is accomplished by the polarization and migration of PMN induced by inflammatory mediators such as interleukin-8 or chemotactic peptides like N-formylmethionyl-leucyl-phenylalanine (fMLP).…”

Section: Introductionmentioning

confidence: 99%

“…15 Furthermore, our previous studies have shown that BC is capable of being used as an ideal biomaterial for artificial blood vessels owing to its nontoxicity and nonimmunogenicity. 16 However, under conditions of immune activation by microbial and periprosthetic infections or chronic inflammation, the relative effect of leukocytes on artificial prosthetic biomaterial, such as BC, has not been identified. Polymorphonuclear leukocytes (PMN) are the first immune cells found at sites of infection or inflammation, and function by eliminating invading microbial pathogens in normal vascular tissue.…”

Section: Introductionmentioning

confidence: 99%

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β₂integrins (CD11/18) are essential for the chemosensory adhesion and migration of polymorphonuclear leukocytes on bacterial cellulose

Kim

Lee

Yang

et al. 2014

J Biomedical Materials Res

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Bacterial cellulose (BC) has been studied widely for applications in biomedical materials such as prosthetic artificial blood vessels owing to its unique characteristics, which include nontoxicity and nonimmunogenicity as compared with synthetic biopolymers such as expanded polytetrafluorethylene (ePTFE). However, to date, studies on the relative effect of leukocytes on BC as a prosthetic vascular graft are insufficient. Polymorphonuclear leukocytes (PMN) play a pivotal role in early-phase immune response to bacterial or periprosthetic infection. PMN recruitment at sites of infection or inflammation mediated by various integrins such as β2 integrin family (CD11/CD18 family). Therefore, we discuss our investigations into the mechanisms by which β2 integrins-mediated chemosensory adhesion and migration of PMN on the vascular graft surface, BC. Our results show that CD11b/CD18 components mainly mediate PMN adherence on BC. CD11b/CD18 displays weak coordination with the other two α subunits (CD11a and CD11c). Furthermore, it was found that the β subunit (CD18) plays a critical role in both the adhesion and migration of N-formylmethionyl-leucyl-phenylalanine (fMLP)-stimulated PMN on BC. The activity of CD18 contrasts with that of the individual α subunits. Among these, only CD11b displayed inhibition of PMN migration on BC surfaces.

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Evaluation of immunoreactivity of in vitro and in vivo models against bacterial synthesized cellulose to be used as a prosthetic biomaterial

Cited by 42 publications

References 39 publications

DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis

DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis

Nanocellulose: Insight into Health and Medical Applications

β₂integrins (CD11/18) are essential for the chemosensory adhesion and migration of polymorphonuclear leukocytes on bacterial cellulose

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Evaluation of immunoreactivity of in vitro and in vivo models against bacterial synthesized cellulose to be used as a prosthetic biomaterial

Cited by 42 publications

References 39 publications

DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis

DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis

Nanocellulose: Insight into Health and Medical Applications

β2integrins (CD11/18) are essential for the chemosensory adhesion and migration of polymorphonuclear leukocytes on bacterial cellulose

Contact Info

Product

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β₂integrins (CD11/18) are essential for the chemosensory adhesion and migration of polymorphonuclear leukocytes on bacterial cellulose