Evaluation of in vitro antioxidant and anticancer activity of Alpinia purpurata

Raj, Chinthamony Arul; Ragavendran, Paramasivam; Sophia, Dominic; Rathi, Muthaiyan Ahalliya; Gopalakrishnan, Vishrawas

doi:10.1016/s1875-5364(12)60053-3

Cited by 11 publications

(9 citation statements)

References 29 publications

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“…It was reported that A. purpurata leaf oil extract was active against S. aureus strains at MIC 10 g/ml. For Gram-negatives it was more than 1000 g/ml [30]. However, in our study the MIC was 5 mg/ml and 1 mg/ml for L. monocytogenes and E. coli, respectively.…”

Section: Cyto-toxic Activity Of Crude Extracts Of T Catappacontrasting

confidence: 71%

In Vitro Antibacterial Activity of Selected Underutilized Plants and Cytotoxic Property of Terminalia Catappa

Somarathna

Premakumara

Mohammad

et al. 2017

Int J Pharm Pharm Sci

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Objective: This study aimed at determining the antibacterial activity of the underutilized plants of Sri Lanka, “Kottamba” (Terminalia catappa), “Purpurata” (Alpinia purpurata) and “Harankaha” (Curcuma zedoaria), against food-borne pathogens. Chemical composition and in vitro cytotxicity of the most active antibacterial plant extract(s) were examined.Methods: Crude rhizome extracts were obtained for all plants whereas in respect of T. catappa, the red pericarp of the fruit was used. The antibacterial activity was determined using the agar disc diffusion and broth dilution assays. Total phenol content, Gas Chromatograph-Mass Spectrometry analysis and cytotoxicity assay were conducted only with the plant which showed the most effective antibacterial activity.Results: T. catappa extract showed significantly (p<0.05) high DIZ (19.6±0.47 mm) against S. aureus 113. A. purpurata showed DIZ (16.3±0.94, 15.0±1.00, 14.3±0.57 mm) against L. monocytogenes V7 (1/2a), S. aureus 25925 and S. aureus MSSASS 25D. The MIC of T. catappa ethanol extract was 10 mg/ml, while MBC was 80 mg/ml for S. aureus 113. The phenolic content of T. catappa ethanol extract was 81.54±1.28 mg GAE/g dry sample and the major compound (31.86 %) was 2, 5-Furandione, 3 methyl. The No-Observed Adverse Effect Concentration (NOAEC) of this extract for COS7 cells was 100 µg/ml whereas for 3T3 it was 300 µg/ml. This indicates that the extract is cytotoxic only at a very high concentration, suggesting that at lower concentrations the extract could be used as a food preservative.Conclusion: The results indicate that T. catappa has potential antibacterial activity as a safe bio-preservative.

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Section: Cyto-toxic Activity Of Crude Extracts Of T Catappacontrasting

confidence: 71%

In Vitro Antibacterial Activity of Selected Underutilized Plants and Cytotoxic Property of Terminalia Catappa

Somarathna

Premakumara

Mohammad

et al. 2017

Int J Pharm Pharm Sci

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“…Lengkuas merah banyak digunakan sebagai suplemen makanan, mengobati sakit kepala, reumatik, sakit tenggorokan dan penyakit ginjal [1]. Disamping itu, ekstrak etanol rimpang lengkuas merah menunjukkan aktivitas yang besar sebagai antibakteri dan antifungi [2], antioksidan maupun antikanker [3].…”

Section: Pendahuluanunclassified

Isolation of Alkaloid Compounds from Ethanol Extract of Rimpang Galang Merah (Alpinia purpurata (Vielli) K. Schum) and nanoparticle production from its Alkaloid Extract. Comparative Study of Antibacterial Properties on Staphylococcus aureus and Eschericia

2018

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Isolation of alkaloid compounds from ethanol extract of red galangal rhizomes to compare their antibacterial properties with extracts formed into nanoparticles has been performed. The isolation of the alkaloid compounds was performed successively by salting using (i) hydrochloric acid (HCl) to pH 3 (when in ethanol) and using (ii) ammonium hydroxide (NH4OH) to pH 10 (when in chloroform). The alkaloid concentrated extract was obtained after chloroform was evaporated using a rotary evaporator. This alkaloid extract was then carried out by TLC silica gel GF254 using chloroform eluent: ethyl acetate (9: 2) to obtain a specific alkaloid type as a single/pure compound. Test of alkaloid purity successfully isolated by one-dimensional or two-dimensional TLC using various types of eluents with varying degrees of polarity, ie acetone, chloroform, ethyl acetate, ethanol and chloroform: ethyl acetate mixture (9: 2). Isolates of pure alkaloids were analyzed using UV-Vis spectrophotometers), FTIR and (LC-MS). The obtained alkaloid isolates were isokuinolin group with UV-visible absorption characteristics at maximum wavelength (λmaks) of 212 nm, 227 nm and 261 nm. The alkaloid isolate also showed the presence of functional groups -OH, -C-H, C = O, C = C, C = N, C-N, and C-O with molecular weight of 262.90 g/mol. The production of ethanol extract nanoparticles containing alkaloid-containing red galangal (EEAlkNPs) was performed using a top-down approach using ultrason (40 kHz, 2x50 watt) for 10 minutes. The EEAlkNPs size was determined by the dynamic light scattering method (DLS) using the Particles size analyzer (PSA) tool and obtained an average particle size of 220.2 nm. The antibacterial properties of EEAlkNPs were tested by disc diffusion method for the culture of S.aureus and E.coli bacteria. It is known that the antibacterial properties of EEAlkNPs are relatively larger than the original ethanol extract at the same concentration, ie, 2000 parts per million (bpj) or g / L.

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“…Additionally, the plant‐derived extracts which contain antioxidant compounds show cytotoxicity towards cancer cells . Ginger is effective in cancer prevention properties and sequential use of ginger can improve the anticancer therapy by inhibiting the proliferation of cancer cells and overcome the side effects caused by long‐term application of chemotherapeutic agents . Different processing (e. g., steaming) will also affect the chemical compositions of ginger which can account for the changes of bioactivities .…”

Section: Introductionmentioning

confidence: 99%

“…[28] Ginger is effective in cancer prevention properties and sequential use of ginger can improve the anticancer therapy by inhibiting the proliferation of cancer cells and overcome the side effects caused by long-term application of chemotherapeutic agents. [29,30] Different processing (e. g., steaming) will also affect the chemical compositions of ginger which can account for the changes of bioactivities. [31] However, the focus of some reports has only been limited to fresh ginger, dried ginger or other herbs, there are few systematic studies concerning the antioxidant and cytotoxic activities of the ginger distillates obtained by multistage MD.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Cytotoxic Activities of Distillates Purified by Means of Molecular Distillation from Ginger Extract Obtained with Supercritical CO₂ Fluid

Wang

Zhao

Lü

et al. 2019

Chemistry & Biodiversity

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The ginger extract obtained with supercritical CO2 fluid was purified by molecular distillation (MD), and the chemical compositions, antioxidant and cytotoxic activities of ginger extract and its distillates were investigated. Analysis revealed that the ginger extract was rich in terpene hydrocarbons, along with oxygenated terpenes and other non‐volatile compounds. The MD distillates were prepared in a series of stages and the active compounds like terpenes and gingerols could be separated by MD. The major compounds of the distillates purified by MD at 40 °C, 80 Pa and 60 °C, 80 Pa were terpene hydrocarbons. Additional distillates obtained by MD at 80 °C, 80 Pa and 100 °C, 60 Pa were predominated by terpene hydrocarbons and oxygenated terpenes. Until the operating conditions of MD reached 150 °C and 2 Pa, some non‐volatile compounds were concentrated in the final distillate. Moreover, antioxidant activities and the cytotoxic effects on three human cancer cells in final MD distillate were superior to other extracts, and this phenomenon could be mainly supported by the phenols. The MD could be used to prepare ginger distillates with better antioxidant and cytotoxic activities.

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Evaluation of in vitro antioxidant and anticancer activity of Alpinia purpurata

Cited by 11 publications

References 29 publications

In Vitro Antibacterial Activity of Selected Underutilized Plants and Cytotoxic Property of Terminalia Catappa

In Vitro Antibacterial Activity of Selected Underutilized Plants and Cytotoxic Property of Terminalia Catappa

Isolation of Alkaloid Compounds from Ethanol Extract of Rimpang Galang Merah (Alpinia purpurata (Vielli) K. Schum) and nanoparticle production from its Alkaloid Extract. Comparative Study of Antibacterial Properties on Staphylococcus aureus and Eschericia

Antioxidant and Cytotoxic Activities of Distillates Purified by Means of Molecular Distillation from Ginger Extract Obtained with Supercritical CO₂ Fluid

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Evaluation of in vitro antioxidant and anticancer activity of Alpinia purpurata

Cited by 11 publications

References 29 publications

In Vitro Antibacterial Activity of Selected Underutilized Plants and Cytotoxic Property of Terminalia Catappa

In Vitro Antibacterial Activity of Selected Underutilized Plants and Cytotoxic Property of Terminalia Catappa

Isolation of Alkaloid Compounds from Ethanol Extract of Rimpang Galang Merah (Alpinia purpurata (Vielli) K. Schum) and nanoparticle production from its Alkaloid Extract. Comparative Study of Antibacterial Properties on Staphylococcus aureus and Eschericia

Antioxidant and Cytotoxic Activities of Distillates Purified by Means of Molecular Distillation from Ginger Extract Obtained with Supercritical CO2 Fluid

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Antioxidant and Cytotoxic Activities of Distillates Purified by Means of Molecular Distillation from Ginger Extract Obtained with Supercritical CO₂ Fluid