Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice

Thummar, Vipul R.; Parasuraman, Subramani; Basu, Debdatta; Raveendran, R

doi:10.1016/j.jtcme.2015.08.004

Cited by 16 publications

(9 citation statements)

References 17 publications

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“…It has been reported that oxidative stress in rat hepatocytes may be improved by drinking water enriched with sage extract [21]. Studies have also shown that the sage extract, rosmarinic acid stimulates the activities of various antioxidant enzymes such as pancreatic catalase, glutathione peroxidase, glutathione-S-transferase and superoxide dismutase in streptozotocin-induced diabetic rats [22].…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxic and hematotoxic effects of sage oil-loaded ifosfamide nanoemulsion in Ehrlich ascites carcinomabearing mice

AlMotwaa¹,

Alkhatib²,

Alkreathy³

2021

Trop. J. Pharm Res

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Purpose: To investigate the hepatotoxic and hematotoxic effects of sage oil-loaded ifosfamide (IFO) nanoemulsion (NE) in Ehrlich ascites carcinoma (EAC)-bearing mice. Methods: Ifosfamide (IFO) was loaded into a NE containing sage oil, and its hepatotoxic and hematotoxic effects were assessed in EAC-bearing mice. Female Swiss albino mice (n = 50) weighing 25 - 30 g (mean weight = 27.5 ± 2.50 g) were randomly assigned to five groups of ten mice each. With the exception of group 1, the mice were inoculated intraperitoneally (i.p.) with 2.5 × 106 EAC/mouse for 48 h. Group I served as negative control, C (-); group II served as positive control, C (+); while groups III - V were treated i.p. with 60 mg/kg IFO in 0.3mL water (free-IFO); 0.3 mL NE (SAGE-NANO), and 60 mg/kg IFO in 0.3 mL SAGE-NANO (SAGE-IFO), respectively. The treatments were administered for three days. Results: Treatment with 60 mg/kg bwt IFO (free-IFO) significantly elevated the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT, p < 0.05). However, subsequent treatment with SAGE-IFO significantly reduced the activity of these liver enzymes (p < 0.05). The concentration of reduced glutathione (GSH) as well as the activities of catalase and glutathione reductase (GR) significantly increased, while malondialdehyde (MDA) level decreased significantly in SAGE-IFO group, when compared with free-IFO group (p < 0.05). Treatment with SAGE-IFO significantly restored white blood cell (WBC) count and platelet levels which were altered by free-IFO (p < 0.05). Conclusion: The results obtained in this study suggest that loading IFO in sage oil-NE greatly reduces its hepatotoxicity and hematotoxicity.

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Section: Discussionmentioning

confidence: 99%

Hepatotoxic and hematotoxic effects of sage oil-loaded ifosfamide nanoemulsion in Ehrlich ascites carcinomabearing mice

AlMotwaa¹,

Alkhatib²,

Alkreathy³

2021

Trop. J. Pharm Res

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“…Rutin, a poly-phenolic bioflavonoid has shown wide range of pharmacological applications due to its significant antioxidant properties and its use is advantageous over other flavonoids as it is a non-toxic and non-oxidizable molecule [40]. To establish the efficacy of any anticancer drug, determination of the prolongation of life span of the treated tumor-bearing hosts as compared to control has been used as an important criterion [41,42]. The results of the survival patterns of the hosts in different groups showed the significant increase in survivability of the hosts after combination treatment as compared to the mice treated with either compound alone (Table 1) which may suggest that combination treatment with rutin plus cisplatin could be a better therapeutic approach against murine ascites Dalton's lymphoma.…”

Section: Discussionmentioning

confidence: 99%

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2018

RJLBPCS

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Rutin, a naturally occurring flavonoid, possesses many pharmacological properties. Cisplatin is a well-known cancer chemotherapeutic drug. However, its full therapeutic efficacy is hindered due to development of various adverse side-effects in the host. The present study was focused on to evaluate rutincisplatin combination therapeutic efficacy and its protective role against cisplatin-induced hematotoxicity in ascites Dalton's lymphoma (DL) bearing mice. Ascites Dalton's lymphoma tumor-transplanted mice were treated with rutin or cisplatin alone and in the combination. The percentage increase in life span (ILS) of the hosts, cell viability, fluorescence-based apoptosis, glutathione and hematological parameters were determined under different treatment conditions. It was observed that cisplatin in combination with rutin has better therapeutic potential against murine ascites Dalton's lymphoma showing about 57 percent more ILS than cisplatin alone. The increased ILS observed during combination treatment could involve increased cytotoxicity and apoptosis in DL cells as compared to alone treatment. The combination treatment caused further decrease in reduced glutathione (GSH) level in tumor cells which could weaken its defensive ability and also assist in tumor cells death thereby increasing the host's survivability. Cisplatin treatment of the tumor-bearing mice caused a decrease in erythrocytes and leukocytes count and hemoglobin content which could lead to develop hematotoxicity in the hosts. However, the combination treatment showed a noteworthy improvement in all these hematological parameters suggesting a protective ability of rutin against cisplatininduced hematotoxicity.

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“…The observed increase in WBC count in phytotreatments is a sign of development of a defense mechanism against malignancy which is in the divergence of the antitumor effect of a chemotherapeutic agent exhibiting a decrease in the WBC count [50]. All the phytotreatments again appear to reduce HB and RBC to a lesser extent compared to the reference drug.…”

Section: Intestinementioning

confidence: 93%

Anti-Melanoma Bio-Efficacy of the Plant Madhuca Longifolia and Its Enhancement Using Bioactive Principle Loaded Gold Nanoparticle

Yadav¹,

Sharma²,

Ganesh³

et al. 2020

Asian J Pharm Clin Res

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Objective: Unexplored in-vivo anti-melanoma bio-efficacy of the plant Madhuca longifolia (bark) has been carried out against C57BL/6 mice. Methods: Optimized experimental conditions of phytofabrication of gold nanoparticles were as follows: flavonoid content (1 ml, 0.5 mg/ml), sodium tetrachloroaurate dihydrate solution (2 ml, 1 mM), and sonication (15 min, 20 KHz) at pH 4. The optical properties; ultraviolet-visible spectrophotometer (UV-Vis), particles size and zeta potential (Zetasizer), miller indices; X-ray diffraction (XRD), morphology; field emission-scanning electron microscope (FE-SEM), particle size; high resolution-transmission electron microscopy (HR-TEM), surface roughness; atomic force microscopy (AFM) and elemental composition; and energy dispersive X-rays (EDX) of flavonoid loaded gold nanoparticles. In-vivo anti-melanoma bio-efficacy has been carried out against C57BL mice. Radioisotopic, hematological, and histopathological studies were carried out using standard procedures. Results: Redox potential of the total flavonoid extracted from the bark of the plant (Madhuca longifolia) has been used for the fabrication of flavonoid loaded gold nanoparticles (F@AuNp) and confirmed for the first time their significant anti-melanoma bio-efficacy. The finding is supported by hematological and histopathological studies carried out in the organs (liver, kidney, and intestine) of C57BL mice. The significant enhancement in phytofabricated F@AuNp compared to native bark extract of the plant has been assigned to enhanced stay period and nanosizing, biocompatibility, nontoxic nature, and enhanced beneficial payload to the cancerous cells. Conclusion: Such phytofabricated gold nanoparticles possess an admirable prospect for the expansion of herbal nanomedicine for anti-melanoma bio-efficacy.

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Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice

Cited by 16 publications

References 17 publications

Hepatotoxic and hematotoxic effects of sage oil-loaded ifosfamide nanoemulsion in Ehrlich ascites carcinomabearing mice

Hepatotoxic and hematotoxic effects of sage oil-loaded ifosfamide nanoemulsion in Ehrlich ascites carcinomabearing mice

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Anti-Melanoma Bio-Efficacy of the Plant Madhuca Longifolia and Its Enhancement Using Bioactive Principle Loaded Gold Nanoparticle

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