Evaluation of interim PET response criteria in paediatric Hodgkin's lymphoma—results for dedicated assessment criteria in a blinded dual-centre read

Abstract

The iPET interpretation assured low interobserver variability. High sensitivity for identification of pHL patients suffering relapse is achieved if [18F]-fluorodeoxyglucose uptake above the MBPS value is rated as a PET-positive finding.

PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study

“…[17][18][19][20][21] Response assessment with the 5-PS has been reported by a number of investigators to have good interobserver agreement in a training set of 50 patients, 22 in a study of 260 advanced HL patients with international expert readers, 23 and in pediatric HL. 24 The 5-PS also improves the positive predictive value of PET compared with previous International Harmonization Criteria. 25 These studies, however, were all retrospective, and the 5-PS was not used to direct therapy.…”

“…7 PET-CT is recommended for response assessment in FDGavid lymphomas using the 5-PS. 34 The 5-PS has good interobserver agreement 22,24,25,[35][36][37] and is predictive of patient outcomes, 29,35,[38][39][40] especially in advanced HL. 37,41 An advantage of the 5-PS is that the threshold used to define complete metabolic response can be altered according to the clinical context or research question.…”

Assessment of Response to Therapy

“…The value of mid-treatment 18F-FDG PET is also confirmed for Hodgkin disease (HD) (Furth et al 2010;Zaucha et al 2009;Markova et al 2008Markova et al , 2009aEich et al 2008a, b;Krochmalczyk et al 2008). It is recommended to use 18F-FDG PET scanning after 4 cycles of BEACOPP regimen (PET-4).…”

Response Assessment Criteria and Their Applications in Lymphoma: Part 1

“…Another study on diffuse large B-cell lymphoma, by Itti et al, found lower interobserver agreement with D5PS (k 5 0.66) than with a semiquantitative counterpart based on SUV max (k 5 0.83) (55). In larger standardized studies of HL that used D5PS, Barrington et al, Furth et al, and Gallamini et al reported k-values of 0.79-0.85, 0.748, and 0.69-0.84, respectively, proving its superiority (56)(57)(58). The implications of these findings on the reproducibility and clinical applicability of the Lugano classification have yet to be determined in prospective studies with large datasets.…”