Evaluation of intestinal transit time of root and leaves of Ipomea sepiaria

Abstract

Ipomoea sepiaria Koenig Ex. Roxb is considered to be one of the source plants of the classical herb Lakshmana. In folklore, the herb is well known for its laxative activity. This plant belongs to Convolvulaceae family. It is observed that the plants of this family especially the species of Ipomoea are rich in purgative resins. The present experimental study was carried out to evaluate the effect of leaf and root of I. sepiaria on intestinal transit time on Swiss albino mice and the test drugs were administered in dose of 400 mg/kg. Evaluation of intestinal transit time was carried out by adopting Kaolin expulsion test and latency of onset of kaolin expulsion in fecal matter. The results shows that both root and leaf samples of I. sepiaria have marked intestinal motility enhancing property, among which leaf sample is found to be better. Hence, for the therapeutic purpose leaf can be preferred to get better activity profile and also to prevent destructive harvesting of the plant.

Assessment of Trisama, an ayurvedic formulation on intestinal transit time in swiss albino mice

“…Therefore, the present experimental study was designed to evaluate the effects on intestinal motility of Trisama powder and decoction dosage forms in Swiss albino mice. It is well established that the drugs having purgative property are supposed to increase intestinal motility;[8] hence, the effect of test drug on intestinal transit time of kaolin was evaluated in mice.…”