Evaluation of LncRNA ANRIL Potential in Hepatic Cancer Progression

Ji, Yongjian; Sun, Hao; Liang, Haiqing; Wang, Yong; Lü, Meili; Guo, Zhaoyang; Lv, Zhuozhen; Ren, Wei

doi:10.1615/jenvironpatholtoxicoloncol.2019028282

Cited by 14 publications

(12 citation statements)

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“…However, detailed information about earlier reports can be found in the following reviews: [ 134 – 136 ]. Additionally, the following bibliographic data [ 134 – 214 ] afford an extensive exposition of the most recent HCC lncRNA-oriented work. Beside the compendious run-through below, Table 5 affords an encyclopedic overview of the lncRNAs studied in these resources which were not discussed in the text for practical reasons.…”

Section: Noncoding Rnasmentioning

confidence: 99%

Hepigenetics: A Review of Epigenetic Modulators and Potential Therapies in Hepatocellular Carcinoma

Yousef

El-Fawal

Abdelnaser

2020

BioMed Research International

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Hepatocellular carcinoma is the fifth most common cancer worldwide and the second most lethal, following lung cancer. Currently applied therapeutic practices rely on surgical resection, chemotherapy and radiotherapy, or a combination thereof. These treatment options are associated with extreme adversities, and risk/benefit ratios do not always work in patients’ favor. Anomalies of the epigenome lie at the epicenter of aberrant molecular mechanisms by which the disease develops and progresses. Modulation of these anomalous events poses a promising prospect for alternative treatment options, with an abundance of felicitous results reported in recent years. Herein, the most recent epigenetic modulators in hepatocellular carcinoma are recapitulated on.

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Section: Noncoding Rnasmentioning

confidence: 99%

Hepigenetics: A Review of Epigenetic Modulators and Potential Therapies in Hepatocellular Carcinoma

Yousef

El-Fawal

Abdelnaser

2020

BioMed Research International

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“…Several lncRNAs act as competing endogenous RNAs for miRNAs, thus regulating expression of cell cycleassociated miRNAs. Examples include (but not limited to): loc285194/miR-211 (176), HOTAIR/miR-1 (23), HOTAIR/ miR-206 (24), and ANRIL/miR-384 (177). In addition to this kind of interaction between lncRNAs and miRNAs, some lncRNAs serve as precursors for miRNAs.…”

Section: Discussionmentioning

confidence: 99%

The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells

et al. 2020

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Cell cycle is regulated by a number of proteins namely cyclin-dependent kinases (CDKs) and their associated cyclins which bind with and activate CDKs in a phase specific manner. Additionally, several transcription factors (TFs) such as E2F and p53 and numerous signaling pathways regulate cell cycle progression. Recent studies have accentuated the role of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the regulation of cell cycle. Both lncRNAs and miRNAs interact with TFs participating in the regulation of cell cycle transition. Dysregulation of cell cycle regulatory miRNAs and lncRNAs results in human disorders particularly cancers. Understanding the role of lncRNAs, miRNAs, and TFs in the regulation of cell cycle would pave the way for design of anticancer therapies which intervene with the cell cycle progression. In the current review, we describe the role of lncRNAs and miRNAs in the regulation of cell cycle and their association with human malignancies.

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“…ANRIL functions as a ceRNA to sponge miRNAs, thereby regulating gene expression in HCC. The high expression of ANRIL in HCC is related to HCC cell proliferation, migration, and invasion; mechanistically, ANRIL exerts its biological action in HCC by sponging miR-384 to upregulate signal transducer and activator of transcription 3 (STAT3) expression[ 85 ]. ANRIL can also promote HCC cell proliferation, metastasis, and invasion by acting as a ceRNA of miR-122-5p[ 86 ].…”

Section: Role Of Lncrnas As Cernas In Hccmentioning

confidence: 99%

Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma

Niu¹,

Wang²,

Dong³

et al. 2020

WJG

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Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are noncoding RNAs (ncRNAs) that occupy over 90% of the human genome, and their main function is to directly or indirectly regulate messenger RNA (mRNA) expression and participate in the tumorigenesis and progression of malignances. In particular, some lncRNAs can interact with miRNAs as competing endogenous RNAs (ceRNAs) to modulate mRNA expression. Accordingly, these RNA molecules are interrelated and coordinate to form a dynamic lncRNA-mediated ceRNA regulatory network. Mounting evidence has revealed that lncRNAs that act as ceRNAs are closely related to tumorigenesis. To date, numerous studies have established many different regulatory networks in hepatocellular carcinoma (HCC), and perturbations in these ceRNA interactions may result in the initiation and progression of HCC. Herein, we emphasize recent advances concerning the biological function of lncRNAs as ceRNAs in HCC, with the aim of elucidating the molecular mechanism underlying these HCC-related RNA molecules and providing novel insights into the diagnosis and treatment of HCC.

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Evaluation of LncRNA ANRIL Potential in Hepatic Cancer Progression

Cited by 14 publications

References 0 publications

Hepigenetics: A Review of Epigenetic Modulators and Potential Therapies in Hepatocellular Carcinoma

Hepigenetics: A Review of Epigenetic Modulators and Potential Therapies in Hepatocellular Carcinoma

The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells

Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma

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