Evaluation of Localized Inflammatory Reactions Secondary to Intramuscular Injections of Enrofloxacin in Striped Bass (Morone Saxatilis)

Scott, Gregory; Law, Mac; Christiansen, Emily F.; Lewbart, Gregory A.; Harms, Craig A.

doi:10.1638/2019-0096

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…Experimental IM injection of 2.27% enrofloxacin in striped bass is associated with severe hemorrhage, necrosis, and inflammation. 13 Findings for the iguana of the present report should serve as a reminder for clinicians to carefully administer medications and consider injection reactions as a differential diagnosis for local neurologic signs. Our findings also illustrate that neurologic examination of nonmammalian species is possible and that a thorough neurologic examination can accurately identify the location of a lesion.…”

Section: Commentsmentioning

confidence: 77%

What Is Your Neurologic Diagnosis?

Pfund

Biegen

Boyer³

et al. 2022

javma

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Section: Commentsmentioning

confidence: 77%

What Is Your Neurologic Diagnosis?

Pfund

Biegen

Boyer³

et al. 2022

javma

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“…This means that muscle inflammation is not caused by enrofloxacin administration. Inflammation of the muscles due to administration of enrofloxacin could occur if the administration was carried out by intramuscular injection [14]. Inflammation of muscles could also be generated by pathogens such as bacteria [15], parasites [16], fungi [17], exposure to heavy metals [18], and administration of nanoparticles [19].…”

Section: Musclementioning

confidence: 99%

Determination of withdrawal time, efficacy, and safety test of enrofloxacin in carp (Cyprinus carpio)

Bond,

Senggagau,

Anshori

2023

E3S Web Conf.

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The use of antibiotic such as enrofloxacin for the treatment of fish diseases needs to be appropriately controlled so that the medicine function effectively and does not cause antibiotic residues above the maximum residues limit (MRL). The study aims to determine the duration of administration, efficacy, and safety of enrofloxacin in carp. The size of the carp used was 10-40 g, with a length of 8-12 cm. The methods used in this study were (a) withdrawal time test, (b) efficacy and safety test, and (c) histopathology analysis. The results of determining enrofloxacin withdrawal time for 0.5 MRL and 1 MRL were two days and eight days, respectively. The survival rates of carp in post-challenge with Aeromonas hydrophila for the positive control and efficacy groups were 86.7% and 88.9%, respectively, and were not significantly different. The results of histopathological observations on the liver, spleen, kidney, and muscle of the carp showed no significant pathological changes between the safety test dose treatment and the control treatment.

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“…Recent studies indicated that this effect could also occur in fish. The intramuscular injection of enrofloxacin in striped bass led to hemorrhage, necrosis, and inflammation [ 141 ].…”

Section: The Safety Of Enrofloxacin Usementioning

confidence: 99%

Enrofloxacin—The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?

Grabowski

Gaffke

Pierzynowska

et al. 2022

IJMS

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Enrofloxacin is a compound that originates from a group of fluoroquinolones that is widely used in veterinary medicine as an antibacterial agent (this antibiotic is not approved for use as a drug in humans). It reveals strong antibiotic activity against both Gram-positive and Gram-negative bacteria, mainly due to the inhibition of bacterial gyrase and topoisomerase IV enzymatic actions. The high efficacy of this molecule has been demonstrated in the treatment of various animals on farms and other locations. However, the use of enrofloxacin causes severe adverse effects, including skeletal, reproductive, immune, and digestive disorders. In this review article, we present in detail and discuss the advantageous and disadvantageous properties of enrofloxacin, showing the benefits and risks of the use of this compound in veterinary medicine. Animal health and the environmental effects of this stable antibiotic (with half-life as long as 3–9 years in various natural environments) are analyzed, as are the interesting properties of this molecule that are expressed when present in complexes with metals. Recommendations for further research on enrofloxacin are also proposed.

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Evaluation of Localized Inflammatory Reactions Secondary to Intramuscular Injections of Enrofloxacin in Striped Bass (Morone Saxatilis)

Cited by 6 publications

References 19 publications

What Is Your Neurologic Diagnosis?

What Is Your Neurologic Diagnosis?

Determination of withdrawal time, efficacy, and safety test of enrofloxacin in carp (Cyprinus carpio)

Enrofloxacin—The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?

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