Evaluation of mediators of oxidative stress and inflammation in patients with acute appendicitis

Machado, Sandra Lorena de Oliveira; Bagatini, Margarete Dulce; Costa, Pauline da; Baldissarelli, Jucimara; Reichert, Karine Paula; Oliveira, Lizielle Souza de; Lemos, Jéssica Gonçalves; Duarte, Thiago; Schetinger, Maria Rosa Chitolina; Morsch, Vera Maria

doi:10.3109/1354750x.2016.1160426

Cited by 20 publications

(15 citation statements)

References 36 publications

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“…The finding of an elevated risk of PD among women who reported appendectomy for appendicitis, but not among those who reported incidental appendectomy, is consistent with the postulated role of inflammation or invasion by a bacterial pathogen in triggering PD pathogenesis. A recent study reported evidence of elevated interleukin‐1α (IL‐1α), among other inflammatory factors, in PD patients, and elevation of IL‐1 has also been noted in patients with acute appendicitis . It is possible that appendicitis in these women could have been the result of invasion by a neurotrophic enteric pathogen that contributed to the triggering of PD pathology .…”

Section: Discussionmentioning

confidence: 99%

“…A recent study reported evidence of elevated interleukin-1α (IL-1α), among other inflammatory factors, in PD patients, 23 and elevation of IL-1 has also been noted in patients with acute appendicitis. 24 It is possible that appendicitis in these women could have been the result of invasion by a neurotrophic enteric pathogen that contributed to the triggering of PD pathology. 1 Alternatively, appendicitis may have promoted a systemic inflammatory response that may have contributed to PD onset, such as the triggering of propagation of α-synuclein from the gut/appendix to the brain.…”

Section: Discussionmentioning

confidence: 99%

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Appendectomy and risk of Parkinson's disease in two large prospective cohorts of men and women

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Appendectomy and risk of Parkinson's disease in two large prospective cohorts of men and women

et al. 2018

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“…Oxidative stress condition develops when the balance becomes disturbed and an inequity among pro‐oxidant and antioxidant occurs. The latest studies have shown that oxidative stress plays a significant role in the pathogenesis of many inflammatory diseases , and oxidative stress induces apoptosis .…”

Section: Introductionmentioning

confidence: 99%

Polydatin reduces Staphylococcus aureus lipoteichoic acid‐induced injury by attenuating reactive oxygen species generation and TLR2‐NFκB signalling

Zhao

Jiang

et al. 2017

J Cellular Molecular Medi

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Staphylococcus aureus (S. aureus) causes severe inflammation in various infectious diseases, leading to high mortality. The clinical application of antibiotics has gained a significant curative effect. However, it has led to the emergence of various resistant bacteria. Therefore, in this study, we investigated the protective effect of polydatin (PD), a traditional Chinese medicine extract, on S. aureus lipoteichoic acid (LTA)‐induced injury in vitro and in vivo. First, a significant improvement in the pathological conditions of PD in vivo was observed, suggesting that PD had a certain protective effect on LTA‐induced injury in a mouse model. To further explore the underlying mechanisms of this protective effect of PD, LTA‐induced murine macrophages were used in this study. The results have shown that PD could reduce the NF‐κB p65, and IκBα phosphorylation levels increased by LTA, resulting in a decrease in the transcription of pro‐inflammatory factors, such as TNF‐α, IL‐1β and IL‐6. However, LTA can not only activate NF‐κB through the recognition of TLR2 but also increase the level of intracellular reactive oxygen species (ROS), thereby activating NF‐κB signalling. We also detected high levels of ROS that activate caspases 9 and 3 to induce apoptosis. In addition, using a specific NF‐κB inhibitor that could attenuate apoptosis, namely NF‐κB p65, acted as a pro‐apoptotic transcription factor in LTA‐induced murine macrophages. However, PD could inhibit the generation of ROS and NF‐κB p65 activation, suggesting that PD suppressed LTA‐induced injury by attenuating ROS generation and TLR2‐NFκB signalling.

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“…Its prevalence in society was reported to be 0.4%. [4][5][6] The most important symptom and findings of acute appendicitis are pain, sensitivity, and rebound tenderness in the right lower quadrant. 7 In the United States of America, 80,000 children are treated for appendicitis every year and this rate is reported to be 4/1,000 in children under 14 years of age.…”

Section: Introductionmentioning

confidence: 99%

The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children

Uğur

Madenci

Kurku

et al. 2020

Journal of Pediatric Infectious Diseases

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Objective The aim of this study was to determine the role of thiol/disulfide homeostasis (TDH) parameters which are new oxidative stress markers for the diagnosis of acute appendicitis (AA) in children with abdominal pain complaints. Methods A total of 40 patients with AA and 45 patients with abdominal pain were included in this study. Two groups were compared in terms of age, gender, white blood cell count, neutrophil-to-lymphocyte ratio, C-reactive protein (CRP), appendix diameter, and TDH parameters (native and total thiol levels, native thiol/total thiol ratio [antioxidant parameters] and disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio [oxidant parameters]). Results Compared with the abdominal pain group, it was found that disulfide level, disulfide/native thiol, and disulfide/total thiol ratios (p < 0.001 for all) in patients with AA were significantly higher and their native thiol level (p = 0.02) and native thiol/total thiol ratio (p < 0.001) were significantly lower. There was no significant difference between the two groups in terms of total thiol level. There was no significant difference between the perforated and nonperforated groups in patients with AA in terms of TDH parameters. In addition, the CRP level was higher in the perforated group than the nonperforated group. Conclusion To our knowledge, the present study is a first in the literature in which TDH parameters were used in children with AA compared with the abdominal pain group. We thought that these parameters may be useful as new biomarkers supporting AA diagnosis in children.

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Evaluation of mediators of oxidative stress and inflammation in patients with acute appendicitis

Abstract: Evaluating these biomarkers could aid in diagnosing AA.

Cited by 20 publications

References 36 publications

Appendectomy and risk of Parkinson's disease in two large prospective cohorts of men and women

Appendectomy and risk of Parkinson's disease in two large prospective cohorts of men and women

Polydatin reduces Staphylococcus aureus lipoteichoic acid‐induced injury by attenuating reactive oxygen species generation and TLR2‐NFκB signalling

The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children

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