Evaluation of neural plasticity in adult stem cells

Ross, Jeffrey; Verfaillie, Catherine M.

doi:10.1098/rstb.2006.2021

Cited by 26 publications

(18 citation statements)

References 88 publications

(117 reference statements)

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“…The fact that NSCs can create functional signal-bearing networks similar to normal neurons has already been demonstrated. [528] Importantly, NSCs can also be developed from hematopoietic CD34-positive stem cells from peripheral blood of adults, [529][530][531][532][533] therefore, making possible the development of the interface with the patient's own stem cells. This will greatly reduce or possibly completely eliminate the immune response of the nervous tissue and can resolve many challenges outlined above.…”

Section: Future Perspectivesmentioning

confidence: 99%

Nanomaterials for Neural Interfaces

et al. 2009

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This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the electronic properties of nanostructures can be tailored to match the charge transport requirements of electrical cellular interfacing. (ii) The unique mechanical and chemical properties of nanomaterials are critical for integration with neural tissue as long‐term implants. (iii) Solutions to many critical problems in neural biology/medicine are limited by the availability of specialized materials. (iv) Neuronal stimulation is needed for a variety of common and severe health problems. This confluence of need, accumulated expertise, and potential impact on the well‐being of people suggests the potential of nanomaterials to revolutionize the field of neural interfacing. In this review, we begin with foundational topics, such as the current status of neural electrode (NE) technology, the key challenges facing the practical utilization of NEs, and the potential advantages of nanostructures as components of chronic implants. After that the detailed account of toxicology and biocompatibility of nanomaterials in respect to neural tissues is given. Next, we cover a variety of specific applications of nanoengineered devices, including drug delivery, imaging, topographic patterning, electrode design, nanoscale transistors for high‐resolution neural interfacing, and photoactivated interfaces. We also critically evaluate the specific properties of particular nanomaterials—including nanoparticles, nanowires, and carbon nanotubes—that can be taken advantage of in neuroprosthetic devices. The most promising future areas of research and practical device engineering are discussed as a conclusion to the review.

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Section: Future Perspectivesmentioning

confidence: 99%

Nanomaterials for Neural Interfaces

et al. 2009

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“…3,[5][6][7] Nevertheless, recent evidence provides further support to the idea of the inherent plasticity of at least some types of adult tissue-specific stem cells. [8][9][10][11][12] The bulge region of the hair follicle serves as a repository of stem cells for hair and skin. The bulge contains cells contributing to the cyclical regeneration of hair and, in response to injury, to the epidermis.…”

Section: Introductionmentioning

confidence: 99%

Neural Potential of a Stem Cell Population in the Hair Follicle

Mignone¹,

Roig-López²,

Fedtsova³

et al. 2007

Cell Cycle

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The bulge region of the hair follicle serves as a repository for epithelial stem cells that can regenerate the follicle in each hair growth cycle and contribute to epidermis regeneration upon injury. Here we describe a population of multipotential stem cells in the hair follicle bulge region; these cells can be identified by fluorescence in transgenic nestin-GFP mice. The morphological features of these cells suggest that they maintain close associations with each other and with the surrounding niche. Upon explantation, these cells can give rise to neurosphere-like structures in vitro. When these cells are permitted to differentiate, they produce several cell types, including cells with neuronal, astrocytic, oligodendrocytic, smooth muscle, adipocytic, and other phenotypes. Furthermore, upon implantation into the developing nervous system of chick, these cells generate neuronal cells in vivo. We used transcriptional profiling to assess the relationship between these cells and embryonic and postnatal neural stem cells and to compare them with other stem cell populations of the bulge. Our results show that nestin-expressing cells in the bulge region of the hair follicle have stem cell-like properties, are multipotent, and can effectively generate cells of neural lineage in vitro and in vivo.

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“…Tissue biopsies from olfactory epithelium represent more practical sources [Roisen et al, 2001;Winstead et al, 2005]. Importantly, new evidence supports the differentiation of AS cells across lineages so that easily accessible stem cells could be used in the therapy of degenerative diseases of the CNS [Ross and Verfaillie, 2008]. For example, neurons and glia can be produced from skin derived precursor cells isolated from human scalp and foreskin [Toma et al, 2005], marrow stromal stem cells [Cho et al, 2005;Togel and Westenfelder, 2007], umbilical cord stem cells [SanchezRamos et al, 2001;Low et al, 2008], and adipose tissue-derived stromal cells [Safford et al, 2002;Schaffler and Buchler, 2007].…”

Section: Human Adult Stem Cellsmentioning

confidence: 99%

Human stem cells for modeling neurological disorders: Accelerating the drug discovery pipeline

Crook

Kobayashi

2008

J of Cellular Biochemistry

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The availability of human stem cells heralds a new era for modeling normal and pathologic tissues and developing therapeutics. For example, the in vitro recapitulation of normal and aberrant neurogenesis holds significant promise as a tool for de novo modeling of neurodevelopmental and neurodegenerative diseases. Translational applications include deciphering brain development, function, pathologies, traditional medications, and drug discovery for novel pharmacotherapeutics. For the latter, human stem cell-based assays represent a physiologically relevant and high-throughput means to assess toxicity and other undesirable effects early in the drug development pipeline, avoiding latestage attrition whilst expediting proof-of-concept of genuine drug candidates. Here we consider the potential of human embryonic, adult, and induced pluripotent stem cells for studying neurological disorders and preclinical drug development.

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Evaluation of neural plasticity in adult stem cells

Cited by 26 publications

References 88 publications

Nanomaterials for Neural Interfaces

Nanomaterials for Neural Interfaces

Neural Potential of a Stem Cell Population in the Hair Follicle

Human stem cells for modeling neurological disorders: Accelerating the drug discovery pipeline

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