Evaluation of Neuropsychiatric Function in Phenylketonuria: Psychometric Properties of the ADHD Rating Scale-IV and Adult ADHD Self-Report Scale Inattention Subscale in Phenylketonuria

Abstract

These findings of reliability, validity, and responsiveness of both the ADHD RS-IV and the ASRS inattention scales, in addition to content validation results, support their use for the assessment of inattention symptoms among persons with PKU aged 8 years or older in both clinical and research settings.

Pegvaliase for the treatment of phenylketonuria: A pivotal, double-blind randomized discontinuation Phase 3 clinical trial

“…Investigators used clinical judgment to decide if a participant should have an observer present during study drug administration or use premedication prior to each dose of study drug with a histamine H1 antagonist, H2 antagonist, and, if tolerated, an antipyretic. Neuropsychiatric assessments for inattention and mood were administered by experienced test raters trained on each instrument, previously validated for use in PKU [22,23]. The ADHD RS-IV instrument was administered by investigators and POMS was self-administered by study participants.…”

“…The ADHD RS-IV instrument was administered by investigators and POMS was self-administered by study participants. The IA subscale score of the ADHD RS-IV is A C C E P T E D M A N U S C R I P T considered more relevant compared to the hyperactivity subscale of the ADHD RS-IV, as inattention symptoms are more prevalent in adults with PKU [23]. The IA subscale score ranges from 0 to 27, with higher scores indicating a greater degree of impairment and a score >9 indicating the presence of inattention symptoms [23].…”

“…The IA subscale score of the ADHD RS-IV is A C C E P T E D M A N U S C R I P T considered more relevant compared to the hyperactivity subscale of the ADHD RS-IV, as inattention symptoms are more prevalent in adults with PKU [23]. The IA subscale score ranges from 0 to 27, with higher scores indicating a greater degree of impairment and a score >9 indicating the presence of inattention symptoms [23]. The POMS instrument consists of a 65-item questionnaire rated using a 5-point Likert scale, and the sum of the scores is reported; scores range from -32 to 200, with higher scores indicating greater mood symptoms [22].…”

Propiedades psicométricas: ADHD Rating Scale IV en formato autoreporte

“…El modelo testeado corresponde con el sustento teórico indicado en el DSM-V 1 (Figura 1), en donde se afirma que la dimensión déficit de atención se compone de los ítems (1-9) y la dimensión hiperactividad-impulsividad se compone de los ítems (10)(11)(12)(13)(14)(15)(16)(17)(18). El procedimiento de AFC se basó en el método robusto de máxima verosimilitud y los parámetros de bondad de ajuste encontrados son χ 2 208,50 (153), p < 0,01, CFI = 0,87, RMSEA 0,047 (0,034-0,059).…”

“…Por lo que, son instrumentos, en especial la ADHD RS IV, de vital importancia en la práctica clínica de la salud mental 15 .…”