Evaluation of Oxidative Stress, the Activities of Paraoxonase and Arylesterase in Patients with Subclinical Hypothyroidism

Cebeci, Egemen; Alıbaz-Öner, Fatma; Usta, Murat; Yurdakul, Selen; Ergüney, Mecdi

doi:10.2310/jim.0b013e31823581dd

Cited by 46 publications

(52 citation statements)

References 40 publications

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“…Similarly, Cebeci et al (30) revealed in their study that PON and arylesterase levels were lower in patients with subclinical hypothyroidism when compared to the healthy control group. Similar to the above studies, we have also found lower arylesterase and log(PON1) levels in patients with subclinical and overt hypothyroidism than in the healthy controls.…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

The relationship between oxidative stress and autoimmunity in Hashimoto's thyroiditis

Ateş

Yılmaz

Altay

et al. 2015

European Journal of Endocrinology

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Objective: We have aimed to study the relation between Hashimoto's thyroiditis (HT) and thyroid autoantibodies and oxidative stress parameters in euthyroid, subclinical and overt hypothyroid stages. Design and methods: A total of 124 patients were included in the study; 93 of whom were newly diagnosed with HT (31 patients in each of the euthyroid, subclinical hypothyroid and overt hypothyroid subgroups), aged over 18 and had not received any prior treatment and 31 of whom were healthy volunteers. Results: Total oxidant status (TOS) and oxidative stress index (OSI) levels were higher, and total antioxidant status (TAS) and total thiol and arylesterase levels were lower in the overt hypothyroid group compared to other groups. TOS and OSI levels increased, and TAS levels decreased significantly in each phase from euthyroid, subclinical hypothyroid, to overt hypothyroid subgroups among HT patients. There was a negative correlation between TAS, log (paraoxonase1) and paraoxonase1/HDL and anti-thyroid peroxidase and a negative correlation between anti-thyroglobulin and total thiol. It was also determined that overt hypothroidism was an individual predictor that effects all of the oxidative stress parameters, but not total thiol, levels. Conclusion: Our results suggest that oxidative stress increases continuously during the development of subclinical hypothyroidism and overt hypothyroidism in patients with HT. To determine whether this is a cause or result, randomized, controlled trials that study the effect of antioxidant treatment on the development of overt hypothyroidism and its consequences, e.g., increase in total cholesterol levels, may be performed in euthyroid and/or subclinical hypothyroid patients with HT.

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Section: European Journal Of Endocrinologymentioning

confidence: 99%

The relationship between oxidative stress and autoimmunity in Hashimoto's thyroiditis

Ateş

Yılmaz

Altay

et al. 2015

European Journal of Endocrinology

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“…Indices of oxidative stress were found to be increased [7,[9][10][11][12][13], decreased [8] or unchanged [14] in hypothyroid state. Meanwhile, there is little and controversial knowledge about oxidative stress in subclinical hypothyroidism defined as the presence of high levels of thyroid stimulating hormone (TSH) and normal values of free triiodothyronine (fT 3 ) and free thyroxine (fT 4 ) [9,[14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress parameters in serum and low density lipoproteins of Hashimoto's thyroiditis patients with subclinical and overt hypothyroidism

Öztürk

Vural

Özderya

et al. 2012

International Immunopharmacology

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“…Previous studies reported increased OS in adult patients with SHT [11-13]; these studies either included only patients with autoimmune hypothyroidism [11-13] or the presence of autoimmune thyroiditis was not reported [20, 21]. Hashimoto thyroiditis is a chronic inflammatory autoimmune disease.…”

Section: Discussionmentioning

confidence: 99%

“…Thiol/disulphide homeostasis is regarded as an indicator of OS [9, 10]. OS markers have been found to be increased in patients with autoimmune SHT [11-13]. …”

Section: Introductionmentioning

confidence: 99%

Dynamic Thiol/Disulphide Homeostasis in Children and Adolescents with Non-Autoimmune Subclinical Hypothyroidism

et al. 2018

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Objective: To evaluate the thiol/disulphide homeostasis in children with non-autoimmune subclinical hypothyroidism (SHT). Subjects and Methods: Thiol/disulphide homeosta sis, involving native thiol (SH), disulphide (SS), and total thiol (SS + SH), was evaluated in 60 children and adolescents who were negative for thyroid auto-antibodies (anti-thyroid peroxidase, anti-thyroglobulin) and had a thyroid-stimulating hormone (TSH) value of > 5 mIU/L, and in 40 sex- and age-matched healthy control subjects who were negative for thyroid autoantibodies and had normal TSH levels. Lipid profiles and urine iodine levels were also determined. Results: SH (466 ± 32.8 vs. 462 ± 32.1 μmol/L p = 0.59), SH + SS (508 ± 34.0 vs. 506 ± 32.7 μmol/L, p = 0.81), SS (21 ± 5.5 vs. 22 ± 5.8 μmol/L, p = 0.41), SS/SH (4.5 ± 1.2 vs. 4.8 ± 1.3%, p = 0.36), SS/SH + SS (4.1 ± 1.0 vs. 4.3 ± 1.1%, p = 0.36) and SH/SH + SS (91 ± 2.1 vs. 91 ± 2.1%, p = 0.31) levels were similar in children with SHT and control subjects (p > 0.05). There was no difference between total cholesterol, triglyceride, and low-density lipoprotein levels in SHT patients and controls. No difference was detected between the patients with or without iodine deficiency in the SHT group in terms of thiol/disulphide homeostasis parameters. Conclusion: The status of dynamic thiol/disulphide homeostasis did not change in children and adolescents with non-autoimmune SHT. Future studies are needed for the evaluation of oxidative stress in patients with long-standing non-autoimmune SHT.

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Evaluation of Oxidative Stress, the Activities of Paraoxonase and Arylesterase in Patients with Subclinical Hypothyroidism

Abstract: The activity of PON and ARE were significantly decreased, and oxidative stress was increased in patients with SH. Lower activities of these 2 biomarkers indicate increased oxidative damage in SH. Atherosclerosis in SH can be attributed to increased oxidative stress.

Cited by 46 publications

References 40 publications

The relationship between oxidative stress and autoimmunity in Hashimoto's thyroiditis

The relationship between oxidative stress and autoimmunity in Hashimoto's thyroiditis

Oxidative stress parameters in serum and low density lipoproteins of Hashimoto's thyroiditis patients with subclinical and overt hypothyroidism

Dynamic Thiol/Disulphide Homeostasis in Children and Adolescents with Non-Autoimmune Subclinical Hypothyroidism

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