Evaluation of Peroperative and Oncological Results in Laparoscopic Surgery of Gastric Cancer in Elderly Patients: Single-Center Study

Gojayev, Afig; Erşen, Ogün; Mercan, Ümit; Yüksel, Cemil; Yalkın, Ömer; Bayar, Sancar; Ünal, Ali Ekrem; Demirci, Salim

doi:10.1089/lap.2020.0472

Cited by 3 publications

(4 citation statements)

References 52 publications

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“…Our study showed that chemotherapy in the nomogram accounted for a large proportion in evaluating whether patients were suitable for PTR. According to a retrospective study, age does not cause senior gastric cancer patients to refuse surgery 24 . However, the perspective must be applied with caution in mGC patients because the benefit of PTR must be evaluated when mGC patients are associated with aging‐related physiologic changes (e.g., decreasing organ function, pharmacokinetic and pharmacodynamic variability, and worsening functional status) 25 .…”

Section: Discussionmentioning

confidence: 99%

“…According to a retrospective study, age does not cause senior gastric cancer patients to refuse surgery. 24 However, the perspective must be applied with caution in mGC patients because the benefit of PTR must be evaluated when mGC patients are associated with aging‐related physiologic changes (e.g., decreasing organ function, pharmacokinetic and pharmacodynamic variability, and worsening functional status). 25 Therefore, our study concluded that age should be specifically analyzed in conjunction with the total score of the nomogram.…”

Section: Discussionmentioning

confidence: 99%

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Identification of optimal primary tumor resection candidates for metastatic gastric cancer: Nomograms based on propensity score matching

Zheng

Zhao

et al. 2023

Cancer Medicine

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Background: This study sought to develop and validate nomograms for screening patients with metastatic gastric cancer (mGC) who are candidates for primary tumor resection (PTR) and evaluating the prognosis of mGC patients after PTR. Methods:From 2010 to 2016, we screened mGC patients with complete data from the Surveillance, Epidemiology, and End Results (SEER) database. Depending on whether or not PTR was performed, we categorized patients into surgery and non-surgery groups. A 1:1 propensity score matching (PSM) analysis was used to balance the characteristics of the two groups. The endpoints were overall survival (OS) and cancer-specific survival (CSS). Two predictive nomograms were developed using logistic regression to assess the likelihood of benefit. Two additional prognostic nomograms were developed to assess prognosis in mGC patients after PTR by Cox regression. Finally, nomograms were evaluated using a variety of methodologies.Results: Our study included 3594 mGC patients who met the criteria. PTR was associated with improved OS and CSS time (median OS time after PSM: 15 vs. 7 months, P < 0.05; median CSS time after PSM: 17 vs. 7 months, P < 0.05). The OS-related predictive nomogram, including age, histologic type, grade, T stage, and chemotherapy, was developed. Moreover, the CSS-related predictive nomogram, including age, histologic type, grade, and chemotherapy, was developed.Sex, histologic type, grade, T stage, N stage, and chemotherapy were found to be correlated with OS. Furthermore, the CSS correlated with histologic type, grade, T stage, N stage, and chemotherapy. Both predictive and prognostic nomograms were found to be valuable and reliable after different types of validation. Conclusion:Predictive nomograms were developed and validated for identifying the optimal PTR mGC candidates. Prognostic nomograms were developed and validated for assessing the prognosis of mGC patients after PTR.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of optimal primary tumor resection candidates for metastatic gastric cancer: Nomograms based on propensity score matching

Zheng

Zhao

et al. 2023

Cancer Medicine

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“…It was noteworthy to note that no standard definition of EGC exists. Previous researchers used artificial cutoff points to divide cases into groups (like 60 [ 10 , 17 ], 70 [ 18 , 19 ], 75 [ 20 , 21 ], and 80 [ 22 , 23 ] years old), then evaluated survival differences between the groups. Here, we performed the KAPS method to determine the most appropriate age partition value to define the EGC group.…”

Section: Discussionmentioning

confidence: 99%

Elderly patients with stage II gastric cancer do not benefit from adjuvant chemotherapy

Guo,

Xiong,

Yin

et al. 2023

World J Surg Onc

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Background With the aging of the population, the burden of elderly gastric cancer (EGC) increases worldwide. However, there is no consensus on the definition of EGC and the efficacy of adjuvant chemotherapy in patients with stage II EGC. Here, we investigated the effectiveness of adjuvant chemotherapy in defined EGC patients. Methods We enrolled 5762 gastric cancer patients of three independent cohorts from the Sixth Affiliated Hospital of Sun Yat-sen University (local), the Surveillance, Epidemiology, and End Results (SEER), and the Asian Cancer Research Group (ACRG). The optimal age cutoff for EGC was determined using the K-adaptive partitioning algorithm. The defined EGC group and the efficacy of adjuvant chemotherapy for them were confirmed by Cox regression and Kaplan–Meier survival analyses. Furthermore, gene set variation analyses (GSVA) were performed to reveal pathway enrichment between groups. Results The optimal age partition value for EGC patients was 75. In the local, SEER, and ACRG cohorts, the EGC group exhibited significantly worse overall survival and cancer-specific survival than the non-EGC group (P < 0.05) and was an independent risk factor. Stratified analyses based on chemotherapy showed that EGC patients derived little benefit from adjuvant chemotherapy. Furthermore, GSVA analysis revealed the activation of DNA repair-related pathways and downregulation of the p53 pathway, which may partially contribute to the observed findings. Conclusion In this retrospective, international multi-center study, 75 years old was identified as the optimal age cutoff for EGC definition, and adjuvant chemotherapy proved to be unbeneficial for stage II EGC patients.

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“…Gastric cancer (GC) is the fifth most common malignancy and third most frequent cause of cancer‐related death worldwide. 1 , 2 , 3 Surgical resection is the only curative approach for resectable GCs; however, locoregional control of advanced GCs may frequently be complicated by postsurgical recurrence and metastasis. The molecular mechanism of GC recurrence and progression is unclear, and investigation of this mechanism is critical for development of targeted therapies to inhibit local recurrence and progression.…”

Section: Introductionmentioning

confidence: 99%

miR‐125a‐5p promotes gastric cancer growth and invasion by regulating the Hippo pathway

Wang

et al. 2021

Clinical Laboratory Analysis

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Evaluation of Peroperative and Oncological Results in Laparoscopic Surgery of Gastric Cancer in Elderly Patients: Single-Center Study

Cited by 3 publications

References 52 publications

Identification of optimal primary tumor resection candidates for metastatic gastric cancer: Nomograms based on propensity score matching

Identification of optimal primary tumor resection candidates for metastatic gastric cancer: Nomograms based on propensity score matching

Elderly patients with stage II gastric cancer do not benefit from adjuvant chemotherapy

miR‐125a‐5p promotes gastric cancer growth and invasion by regulating the Hippo pathway

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