Evaluation of phytochemical composition, toxicity in Drosophila melanogaster and effects on antibiotics modulation of Plathymenia reticulata Benth extract

Luna, Ewerton Moraes; Freitas, Thiago Sampaio de; Campina, Fábia F.; Costa, Maria do Socorro; Rocha, Janaína Esmeraldo; Cruz, Rafael Pereira da; Júnior, D.L. Sena; Silveira, Z.S.; Macêdo, Nair Silva; Pinheiro, Jacqueline Cosmo Andrade; Pereira-Júnior, Francisco Nascimento; Lisboa, Maria Amanda Nobre; Cruz, Gabriel Venâncio; Júnior, João Tavares Calixto; Teixeira, Alexandre Magno Rodrigues; Coutinho, Henrique Douglas Melo

doi:10.1016/j.toxrep.2021.03.020

Cited by 5 publications

(2 citation statements)

References 51 publications

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“…) Antioxidant, in vitro and in vivo antitumor effects [101,102] It is important to underscore that several studies have assessed the toxicity of various plants, with many confirming their safe use [2,54,103,104,[104][105][106][107]. These studies provide additional evidence supporting their therapeutic potential, which is the focus of this work.…”

Section: Sterculia Striatamentioning

confidence: 89%

New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome

Monteiro-Alfredo,

Macedo,

de Picoli Souza

et al. 2023

IJMS

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Brazil has several important biomes holding impressive fauna and flora biodiversity. Cerrado being one of the richest ones and a significant area in the search for new plant-based products, such as foods, cosmetics, and medicines. The therapeutic potential of Cerrado plants has been described by several studies associating ethnopharmacological knowledge with phytochemical compounds and therapeutic effects. Based on this wide range of options, the Brazilian population has been using these medicinal plants (MP) for centuries for the treatment of various health conditions. Among these, we highlight metabolic diseases, namely obesity and its metabolic alterations from metabolic syndrome to later stages such as type 2 diabetes (T2D). Several studies have shown that adipose tissue (AT) dysfunction leads to proinflammatory cytokine secretion and impaired free fatty acid (FFA) oxidation and oxidative status, creating the basis for insulin resistance and glucose dysmetabolism. In this scenario, the great Brazilian biodiversity and a wide variety of phytochemical compounds make it an important candidate for the identification of pharmacological strategies for the treatment of these conditions. This review aimed to analyze and summarize the current literature on plants from the Brazilian Cerrado that have therapeutic activity against obesity and its metabolic conditions, reducing inflammation and oxidative stress.

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Section: Sterculia Striatamentioning

confidence: 89%

New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome

Monteiro-Alfredo,

Macedo,

de Picoli Souza

et al. 2023

IJMS

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“…Further research on phytochemical therapy is essential due to limited scientific evidence and the need for more standardization of the production. The quality and quantity of the phytochemicals depend on the extraction and cultivation, making the production process somewhat expensive[208][209][210][211][212].…”

mentioning

confidence: 99%

Emerging strategies and therapeutic innovations for combating drug resistance in Staphylococcus aureus strains: A comprehensive review

Gopikrishnan,

Haryini,

2024

J Basic Microbiol

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In recent years, antibiotic therapy has encountered significant challenges due to the rapid emergence of multidrug resistance among bacteria responsible for life‐threatening illnesses, creating uncertainty about the future management of infectious diseases. The escalation of antimicrobial resistance in the post‐COVID era compared to the pre‐COVID era has raised global concern. The prevalence of nosocomial‐related infections, especially outbreaks of drug‐resistant strains of Staphylococcus aureus, have been reported worldwide, with India being a notable hotspot for such occurrences. Various virulence factors and mutations characterize nosocomial infections involving S. aureus. The lack of proper alternative treatments leading to increased drug resistance emphasizes the need to investigate and examine recent research to combat future pandemics. In the current genomics era, the application of advanced technologies such as next‐generation sequencing (NGS), machine learning (ML), and quantum computing (QC) for genomic analysis and resistance prediction has significantly increased the pace of diagnosing drug‐resistant pathogens and insights into genetic intricacies. Despite prompt diagnosis, the elimination of drug‐resistant infections remains unattainable in the absence of effective alternative therapies. Researchers are exploring various alternative therapeutic approaches, including phage therapy, antimicrobial peptides, photodynamic therapy, vaccines, host‐directed therapies, and more. The proposed review mainly focuses on the resistance journey of S. aureus over the past decade, detailing its resistance mechanisms, prevalence in the subcontinent, innovations in rapid diagnosis of the drug‐resistant strains, including the applicants of NGS and ML application along with QC, it helps to design alternative novel therapeutics approaches against S. aureus infection.

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Toxic potential of botulinum toxin type A on senescence in a Drosophila melanogaster model

et al. 2021

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Evaluation of phytochemical composition, toxicity in Drosophila melanogaster and effects on antibiotics modulation of Plathymenia reticulata Benth extract

Abstract: Graphical abstract Hghlights The HEPrB showed direct antibacterial activity. The HEPrB showed no bacterial resistance modifying activity. This negative effect must be due the antioxidant effect of phenolic compounds.

Cited by 5 publications

References 51 publications

New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome

New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome

Emerging strategies and therapeutic innovations for combating drug resistance in Staphylococcus aureus strains: A comprehensive review

Toxic potential of botulinum toxin type A on senescence in a Drosophila melanogaster model

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