Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS

Nicolescu, Cristian; Bedreag, Ovidiu Horea; Osakwe, Henry; Pop, Anamaria; Nicolescu, Laura

doi:10.37358/rc.17.9.5852

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…In the same time we can take into consideration another possible mechanism of lowering the concentration of plasmatic albumin-hemodilution, iatrogenic, induced by the perfusion solutions [4,5].…”

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confidence: 99%

The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions

Nicolescu¹,

Pop²,

Mihu³

et al. 2018

Rev. Chim.

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This article presents an observational randomized prospective study done on 65 patients, who underwent major surgical interventions in the field of orthopedic surgery-total hip replacement or general surgery � total colectomy. The level of albuminemia in these cases were determined before the surgical intervention, after 6 hours of the intervention and after 24 h of the intervention. The measurements of the plasmatic concentration of the pro-inflammatory cytokines Tumor Necrosis factor -alpha (TNF-alpha) and interleukin 6 (IL6) were simultaneously done with the determination of the plasmatic levels of albumin. Values of hemoglobin and hematocrit were determined 24 h after the surgical procedure in order to exclude hemodilution, which could lead to a possible drop in the levels of plasmatic albumin. After the collection of the data, the statistical work was done and it consisted of descriptive statistics, correlation and comparison tests as well as statistical validation tests. Obtained results indicate that IL-6 plays a major role comparatively with that of TNF-alfa, regarding the decrease of the plasmatic level of albumin, and due to this, the primordial cause for hypoalbuminemia is an acute hepatic phase reaction. Supplemental permeability of the capillary wall under the action of TNF alpha has a secondary role, but could lead to a faster decrease in plasmatic albumin in the first hours after the surgical procedure.

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confidence: 99%

The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions

Nicolescu¹,

Pop²,

Mihu³

et al. 2018

Rev. Chim.

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“…The severity of this case with altered mental status and cardiac failure on admission to ICU should be noted. Patient’s altered mental status could be caused by possible cerebral edema [ 24 ], edema that can be explained by tissue hypoxia due to severe anemia [ 25 ] and also by the low level of albumin [ 26 , 27 ]. Clinical research shows that hypoalbuminemia is frequently determined in case of critical patient with systemic inflammatory syndrome [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Esophageal ulcer associated with mild hemophilia A: case report

Nicolescu¹,

Neşiu²,

Uzum³

et al. 2022

Rom J Morphol Embryol

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In this paper, we present the case of a 68-year-old male with personal medical history of coagulopathy issues, who presented to our Emergency Room (Emergency County Hospital, Arad, Romania) with bleeding of the superior tract of the digestive system; the case was difficult to manage, thus warranting the intervention of the Department of Gastroenterology. Endoscopy was performed to localize the site of bleeding and to stop the hemorrhage. This procedure was not successful. The patient was transferred to our Intensive Care Unit where different medications, such as proton pump inhibitor, hemostatic agent and prokinetic drugs were administered. Unfortunately, our attempt to stop bleeding failed; this led us to expand our investigation. We focused on a possible hemophilia as the cause of bleeding, which was confirmed as hemophilia A through the coagulometry test after a period of three days. Patient medical history and coagulation test led us to believe that this is a very rare case of a mild hemophilia A. Finally, the correction of Factor VIII deficiency and repeated endoscopic hemostasis clip was able to stop patients bleeding and ensured a favorable clinical evolution of the patient.

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“…Special attention was required for critically ill patients who were more prone to exhibit added complications. An increase in microvascular permeability as a systemic inflammatory response due to surgical trauma in combination with a COVID-19-stimulated inflammatory response can be fatal [ 15 ]. Testing to detect COVID-19 was implemented on a large scale.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Non-Pharmacological Measures Implemented in the Management of the COVID-19 Pandemic in Romania

et al. 2022

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The management of the COVID-19 pandemic in Romania has included the involvement of not only the medical system, but also that of the administrative and social services. All these organizations are working together to lower the impact on the health of the general population, to increase the health system’s response capabilities and even to diminish the negative effects upon the economy due to the epidemic’s length. Therefore, non-pharmacological measures (NPMs) imposed through restrictive measures (administrative, economic and individual) have influenced the evolution of morbidity and mortality. Even from the first months of the pandemic’s progression, researchers have shown the impact of the NPMs’ existence, as there were many studies on all NPMs in conjunction, as well as those targeting specific measures such as school closures. Our study started by establishing a temporal relationship between the non-pharmacological measures found in most countries (wearing a mask, washing hands and physical distancing, limiting economic activities, closing schools, limiting internal and international movement, banning public and private events in closed spaces) and the evolution of the pandemic in Romania. The degree of novelty brought by this study consists of extending the analysis to the pre-existing state of the health system and to the measures meant to increase the resilience of the population, as well as to the measures aimed at reducing the type of risk, and factors that can equally influence the evolution of the number of cases. The results of the statistical analysis show the important effects of certain NPMs (mask mandates, online schooling, decisions regarding imposing or lifting local restrictions) as well as the reduced impact of other measures (hand disinfection, social distancing or the restriction of public and private events). Hence, it can be concluded that during such pandemics, implementing quick, simple measures can prevent the spread of the disease and help fight the contagion in a better manner.

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Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS

Cited by 5 publications

References 10 publications

The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions

The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions

Esophageal ulcer associated with mild hemophilia A: case report

Evaluation of Non-Pharmacological Measures Implemented in the Management of the COVID-19 Pandemic in Romania

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