Evaluation of Plasma Total Antioxidant Capacity Levels and Osteocalcin in Prediabetes and Healthy Subjects

Abstract

Prediabetes can also be termed as intermediate or borderline hyperglycaemia. These individuals were defined as having impaired fasting glucose IFG. Prediabetes is associated with oxidative stress predisposing the patients to an increased risk of cardiovascular disorders. Osteocalcin OCN is a protein that is secreted in large amounts in the bone extracellular matrix. OCN regulates Beta cell proliferation insulin gene expression and secretion suggesting a potential role in glucose metabolism and in the pathogenesis of glucose alterations in Type2 Diabetes mellitus T2DM physiopathology. Oxidative stress has an inhibitory role on osteoblast. Hence this study was carried out with a total of 80 male subjects within age group of 30-70 years containing 40 controls and 40 cases. Total antioxidant capacity TAC and OCN were evaluated in prediabetic and healthy subjects and were correlated among the study groups. This may lay a step mainly in early diagnosis of diabetes and prevent its complications.