Evaluation of poly (vinyl alcohol) based cryogel–zinc oxide nanocomposites for possible applications as wound dressing materials

Chaturvedi, Archana; Bajpai, A. K.; Bajpai, Jaya; Singh, Sunil Kumar

doi:10.1016/j.msec.2016.04.054

Cited by 87 publications

(27 citation statements)

References 41 publications

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“…The complete water uptake of the wound dressings was in the order of F > E > A > B > I > C over a period of 24 h. Wound dressings F and E contained ZnO NPs which contributed to the high water uptake of the wound dressing. The presence of the ZnO NPs in the wound dressings enhanced the expansion of the wound dressing network, thereby creating pores for water absorption . The hydrophilic nature of the polymers used for the preparation of the wound dressings also contributed to the high water uptake.…”

Section: Resultsmentioning

confidence: 99%

Development, characterization, and in vitro evaluation of water soluble poloxamer/pluronic‐mastic gum‐gum acacia‐based wound dressing

Buyana

Aderibigbe

Ray

et al. 2019

J of Applied Polymer Sci

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Bacterial infections are serious complications associated with wounds. Wounds can become chronic due to bacterial infections. In this research, lyophilized wound dressings were prepared from poloxamer, pluronic, mastic gum, and gum acacia. The wound dressings were loaded with metal‐based nanoparticles and carbon‐based materials. They exhibited effective antibacterial activity, water‐soluble, biodegradable with the capability to absorb large amounts of wound exudates. The bandages were analyzed using Fourier transform infrared spectroscopy, scanning electron microscopy/energy‐dispersive X‐ray spectroscopy, thermogravimetric analysis, and transmission electron microscopy followed by porosity and water uptake. TEM confirmed the successful incorporation of the metal‐based NPs and carbon‐based materials into the wound dressings. The TGA confirmed that the wound dressings are thermally stable. The wound dressings were also characterized by a high uptake of water to form a gel which was soluble in water indicating their useful application for wounds with large wound exudate, sensitive and damaged skin. The unique properties of the wound dressings indicate that they are potential materials for the treatment of chronic wounds in patients with sensitive skin. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48728.

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Section: Resultsmentioning

confidence: 99%

Development, characterization, and in vitro evaluation of water soluble poloxamer/pluronic‐mastic gum‐gum acacia‐based wound dressing

Buyana

Aderibigbe

Ray

et al. 2019

J of Applied Polymer Sci

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“…5 and 6). Stabilization of ZnO nanoparticles is performed in possible applications of ZnO nanoparticles as wound dressing materials (Chaturvedi et al, 2016). The cell cycle analysis of MCF-7 cells incubated with ZnO-MTCP demonstrated an increase in the percentage of cells in S phase compared with controls (Fig.…”

Section: 0 Discussionmentioning

confidence: 99%

Augmentation of the cytotoxic effects of zinc oxide nanoparticles by MTCP conjugation: Non-canonical apoptosis and autophagy induction in human adenocarcinoma breast cancer cell lines

Mozdoori

Safarian

2017

Materials Science and Engineering: C

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Zinc oxide nanoparticles are very toxic, but their agglomeration reduces their lethal cytotoxic effects. Here we tested the hypothesis that conjugation of ZnO nanoparticles via Meso-Tetra (4-Carboxyphenyl) Porphyrin (MTCP) could provide electrostatic or steric stabilization of ZnO nanoparticles and increase their cytotoxic effects. The cytotoxicity and cell death induction were assessed using two human breast adenocarcinoma cell lines (MCF-7 and MDA-MB-468). The MTT results indicated that the toxicity of ZnO nanoparticles was significantly increased upon MTCP conjugation. Annexin/PI and real time RT-PCR results demonstrated that the ZnO-MTCP nanoparticles induced cell death via different non-canonical pathways that are under ca2+ control. Calcium signaling could regulate lysosomal dependent apoptosis and death autophagy, and killing of the two selected types of breast cancer cells.

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“…However, the inherent drawbacks of cryogels are scarce functional monomers or crosslinkers with high activity and good water solubility for direct application or functionalization, difficulty in adjusting macropore structure, and the rather low specific surface area, which have been considered as the major challenges to broaden their applications [10]. Presently, most cryogels are used for purification of large biomolecules [11], such as DNA or dehydrogenase, chromatographic separation or capturing of proteins [12], tissue engineering [13], cell culturing [14], and so on. However, some cryogel composites have been exploited by traditional embedding of functional particles during cryogelation or immobilizing them on the pore surface of cryogels [15,16].…”

Section: Introductionmentioning

confidence: 99%

Organized cryogel composites with 3D hierarchical porosity as an extraction adsorbent for nucleosides

Zhao

Zou

Wang

et al. 2019

J of Separation Science

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Macroscopic monoliths are highly desirable in many fields of application. Herein, well organized organic–inorganic cryogel composite with a three‐dimensional hierarchical meso‐ and macroporous structure are presented, which were produced by in situ copolymerization of mesoporous multifunctional silica (size: 1–20 μm; pore: 2–20 nm mostly) and monomers (hydroxyethyl methacrylate and diallyldimethylammonium chloride) in water below the freezing point. This copolymerization method effectively adjusted the macropores of the basic cryogel, and the nanosilica was more homogeneously dispersed in the basic cryogel. The specific surface area of the cryogel composite was increased 17 times versus than that of the basic cryogel. The abundant meso‐ and macroporous pores on the cryogel composite provided sufficient reactive sites favorable for the efficient mass transport of target compounds. When the cryogel composite, as solid phase extraction adsorbent, was coupled with high‐performance liquid chromatography, an analytical tool, the nucleosides were quantified with good selectivity, lower detection limits (0.9–1.3 ng/mL) and satisfactory recoveries of greater than 80% from spiked human serum.

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Evaluation of poly (vinyl alcohol) based cryogel–zinc oxide nanocomposites for possible applications as wound dressing materials

Cited by 87 publications

References 41 publications

Development, characterization, and in vitro evaluation of water soluble poloxamer/pluronic‐mastic gum‐gum acacia‐based wound dressing

Development, characterization, and in vitro evaluation of water soluble poloxamer/pluronic‐mastic gum‐gum acacia‐based wound dressing

Augmentation of the cytotoxic effects of zinc oxide nanoparticles by MTCP conjugation: Non-canonical apoptosis and autophagy induction in human adenocarcinoma breast cancer cell lines

Organized cryogel composites with 3D hierarchical porosity as an extraction adsorbent for nucleosides

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