Evaluation of poly ε-caprolactone electrospun nanofibers loaded with Hypericum perforatum extract as a wound dressing

Pourhojat, Faegheh; Sohrabi, Mahmoodreza; Shariati, Shahab; Mahdavi, Hamid; Asadpour, Leila

doi:10.1007/s11164-016-2623-7

Cited by 58 publications

(46 citation statements)

References 34 publications

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“…The SEM images show that both layers exhibit a random distribution of nanofibers with interconnected pores. The average diameters of the smooth PCL structure were determined to be 277.63 ± 85.19 nm, which is in agreement with other studies performed with PCL [44]. In turn, the average fiber diameter of the smooth and bead-free structures of PVA_CS-TPP was decreased from 323.85 ± 91.07 nm to 284.34 ± 75.79 nm when the crude CA extract was incorporated, as a result of reduction of the viscosity of the electrospinning solution.…”

Section: Scanning Electron Microscopy (Sem) Imaging and Analysissupporting

confidence: 91%

Preparation and Characterization of Electrospun Double-layered Nanocomposites Membranes as a Carrier for Centella asiatica (L.)

2020

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A wide range of naturally derived and synthetic biodegradable and biocompatible polymers are today regarded as promising materials for improving skin regeneration. Alongside this, these materials have been explored in conjunction with different types of antimicrobial and bioactive agents, especially natural-derived compounds, to enhance their biological properties. Herein, a double-layered nanocomposite dressing membrane was fabricated with two distinct layers. A bottom layer from Chitosan-Sodium tripolyphosphate (CS-TPP) and Poly(vinyl alcohol) (PVA) containing Centella asiatica (L.) (CA) was electrospun directly over a Polycaprolactone (PCL) layer to improve the biologic performance of the electrospun nanofibers. In turn, the PCL layer was designed to provide mechanical support to the damaged tissue. The results revealed that the produced double-layered nanocomposite membrane closely resembles the mechanical, porosity, and wettability features required for skin tissue engineering. On the other hand, the in vitro drug release profile of the PCL/PVA_CS-TPP containing CA exhibited a controlled release for 10 days. Moreover, the PVA_CS-TPP_CA’s bottom layer displayed the highest antibacterial activity against Staphylococcus aureus (S. aureus) (99.96 ± 6.04%) and Pseudomonas aeruginosa (P. aeruginosa) (99.94 ± 0.67%), which is responsible for avoiding bacterial penetration while endowing bioactive properties. Finally, the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay showed that this nanocomposite membrane was not cytotoxic for normal human dermal fibroblasts (NHDF) cells. Therefore, these findings suggest the potential use of the double-layered PCL/PVA_CS-TPP_CA as an efficient bionanocomposite dressing material.

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Section: Scanning Electron Microscopy (Sem) Imaging and Analysissupporting

confidence: 91%

Preparation and Characterization of Electrospun Double-layered Nanocomposites Membranes as a Carrier for Centella asiatica (L.)

2020

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“…fabricated a nontoxic and biocompatible herbal‐based wound dressing. They encapsulated Hypericum perforatum alcoholic extract within PCL electrospun nanofibrous scaffolds . The antibacterial performance of the wound dressing was evaluated using disk diffusion technique against the strains of Staphylococcus aureus and Escherichia coli .…”

Section: Classification Of Wound Dressingsmentioning

confidence: 99%

Wound dressings: Current advances and future directions

Ghomi

Khalili

Khorasani

et al. 2019

J of Applied Polymer Sci

608

247

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Wound healing is a complicated and continuous process affected by several factors, which needs an appropriate surrounding to achieve accelerated healing. Wound healing process recruits three different phases: inflammation, proliferation, and maturation. Due to the different types of wounds, as well as the advancement in medical technology, various products have been developed to repair different skin lesions. Our objective is to investigate the advancement in wound dressings from traditional to the current methods of treatment. The article presents the characteristics of an ideal wound dressing, the requirements for the appropriate selection of different types of wounds, and a detailed classification of wound dressings. Animal origin, herbal origin, and synthetic dressings are firstly introduced and reviewed. Then, nonmedicated dressings including alginate, hydrogel, and hydrocolloid dressings, as well as medicated dressings are discussed. Finally, the developmental prospectives of the new generations of wound dressings for future researches are presented. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47738.

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“…Thymol is a phenolic compound that is one of the most important and abundant components in the thyme or Thymus vulgaris L. (T. vulgaris) essence, and extract also helps wound healing (Karami, Rezaeian, Zahedi, & Abdollahi, 2013). Karimi et al used thymol with PCL and provided the acceptable antibacterial nanofibers that could be an option for wound dressing (Pourhojat et al, 2017). Karami et al also evaluated the nanofibers containing thymol for use in wound dressing.…”

Section: Thymolmentioning

confidence: 99%

“…Nanofibers are one of the types of nanostructures. Electrospinning is one of the best methods for the production of nanofibers (Pourhojat et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Medicinal plants used in wound dressings made of electrospun nanofibers

Fatehi

Abbasi

2020

J Tissue Eng Regen Med

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Nanofibers are a type of nanostructures, which due to their unique properties can be used in wound dressing, and electrospinning is a good way to produce them. The benefits of wound dressings made of electrospun nanofibers include a large surface area to volume ratio, high absorption of secretions from the wound, and high air permeability, mimicking the morphology of extracellular matrix (ECM) of the damaged tissue and the possibility of the gradual release of the drug agents loaded on nanofibers. Because of the adaptability of plants to the body, low side effects and the prevalence of antibiotic resistance, interest in using plants is increasing. Combining nanofibers with plants is a way to integrate the physical properties of the structure of nanofibers and the chemical and antibacterial properties of the plants. In recent years, many plants in the forms of extracts, essential oils, and pure active ingredients have been used in the electrospininng and production of nanofibercontaining plants; some of the plants may be a good choice for wound dressings made of electrospun nanofibers.

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Evaluation of poly ε-caprolactone electrospun nanofibers loaded with Hypericum perforatum extract as a wound dressing

Cited by 58 publications

References 34 publications

Preparation and Characterization of Electrospun Double-layered Nanocomposites Membranes as a Carrier for Centella asiatica (L.)

Preparation and Characterization of Electrospun Double-layered Nanocomposites Membranes as a Carrier for Centella asiatica (L.)

Wound dressings: Current advances and future directions

Medicinal plants used in wound dressings made of electrospun nanofibers

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