Evaluation of Potential Antiviral Activity of the Hydroalcoholic Extract of Lemon Balm L. against Herpes Simplex Virus Type 1

Roudsari, Rouhollah Vahabpour; Shahrabadi, M Shamsi; S.H.R., Monavari; Sajjadi, Seyed Ebrahim; Sajjadi, Nancy

doi:10.21859/isv.4.3.4.52

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…Current therapeutic antiviral drugs have limited clinical efficiency and toxic side effects (3). Antiviral agents of plant origin are easily accessible, mostly nontoxic, and inexpensive (10). Garlic, with a long history of traditional medications, is shown to be effective against different microorganisms including viruses.…”

Section: Discussionmentioning

confidence: 99%

“…These mutations make it extremely difficult to develop effective vaccines and drugs against the virus (2). Therefore it is an essential need to use some of the traditional medicines and combine them with modern medicine to inhibit the viral activity (10). Garlic may be one of the most famous herbal remedies to be used by in human history-dating back to ancient cultures.…”

Section: Introductionmentioning

confidence: 99%

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Antiviral activity of garlic extract on Influenza virus

2009

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Influenza virus is the most important cause of annual morbidities and mortalities worldwide with numerous antigenic drifts and shifts. Inaccessibility to effective drugs and vaccines has made world health authorities to be interested in traditional medicine in order to prevent spread of the infectious agent. Garlic is one of the most famous of all plants in human history. It has been shown that garlic extract has various effects on different diseases. The aim of this study was to evaluate garlic extract antiviral activity against influenza virus in cell culture. To study the potential antiviral activity, MDCK (Madin-Darbey Canin Kidney) cells were treated with effective minimal cytotoxic concentration of the extract and 100 TCID50 (50% Tissue Culture Infectious Dose) of the virus during infection at different time periods. The viral titers were determined by hemagglutination (HA) and TCID50 assays. The antiviral effect of the extract was studied at 1, 8 and 24 hours after treatment on the culture. To measure the amount of the viral genome synthesized at different times after treatment, RNA extraction, Reverse TranscriptionPolymerase Chain Reaction (RT-PCR) and free band densitometry software were performed. Although the precise mechanism has not been defined yet, it was found that garlic extract with a good selectivity index (SI) has inhibitory effect on the virus penetration and proliferation in cell culture.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiviral activity of garlic extract on Influenza virus

2009

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“…These mutations make it extremely diffi cult to develop effective vaccines and drugs against the virus [9]. Therefore it is an essential need to use some of the traditional medicines and combine the modern drug to inhibit the viral activity [10]. principles have been attributed to its poly sulfi des which react with -SH groups free radicals and also stimulants immune cells such as T and Natural killer cells and macrophages.…”

Section: Discussionmentioning

confidence: 99%

Clinical Study of the effects of Immutonic capsule in human volunteers with flu symptoms

Alkadi¹,

Hk²,

Hk³

2020

Arch Pulmonol Respir Care

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Introduction: Many herbs and natural food materials have been historically recognized as an effective panacea that can establish a balanced infl ammatory response and promoting healthy immune response as well as have antibacterial and viral effects. The clinical use of some medications can cause serious side effects. We proposed that natural ingredients could serve as a better therapeutic approach. Objective: The study aimed to evaluate the effect of IMMUTONIC capsule in human volunteers with fl u symptoms. Methods: Twenty-four male and female adult volunteers, aged between 21 and 60 years were selected for the study. Study design: The study has a randomized clinical trials for one week. Volunteers were taken IMMUTONIC capsule three times daily after meal for one week. Improving of Flu symptoms were follow up after 3 days and 7 days using improving health scale 0-5. Results: fl u symptoms and appetite were signifi cantly improving after 3 days of follow up at p <0.05 , while after 7 days were highly signifi cant improving health at p < 0.05. Conclusion: The present study indicated that Immutonic capsule improves Flu symptoms via improved immune system and its antibacterial & viral effects as well as increased appetite which lead to good feeding.

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“…. Therefore it is an essential need to use some of the traditional medicines and combine the modern drug to inhibit the viral activity [12]. H O. Kadi [13], reviewed that garlic, onions, black bean, ginger, black and green pepper, which have an anti-virus effect [14].…”

Section: Introductionmentioning

confidence: 99%

The effects of immutonic capsule on CD4 T-Lymphocytes cells count: A case report

Kadi¹,

Hk²,

Hk³

2020

Glob J Infect Dis Clin Res

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Introduction: Many herbs and natural food materials have been historically recognized as an effective that can establish a balanced infl ammatory response and promoting healthy immune response as well as have antibacterial and viral effects. The clinical use of some medications can cause serious side effects. We proposed that natural ingredients could serve as food supplement, immune tonic and antibacterial & viral which a better prophylactic and therapeutic approach against COVID-19 and others infections. Case presentation: A 52-years-old Yemeni female normal healthy volunteer for taken Immutonic capsule three times after meal daily for one week. She was free from signifi cant cardiac, hepatic, renal, pulmonary, gastrointestinal, neurological or hematological disease as determined by way of medical histories, physical examinations. Blood CD4 T-Lymphocytes cells was tested before and after taken IMMUTONIC capsule. The results show that Immutonic capsule increased CD4 T-Lymphocytes cells count from 49.7% to 61.4% of total white blood cells which was 4.1x103/UL and 4.0x103/UL respectively. Conclusion: The present case indicated that Immutonic capsule boosting and enhancing immune system which can be used as better prophylactic, boosting immunity and therapeutic against COVID-19 and others infections.

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Evaluation of Potential Antiviral Activity of the Hydroalcoholic Extract of Lemon Balm L. against Herpes Simplex Virus Type 1

Cited by 7 publications

References 13 publications

Antiviral activity of garlic extract on Influenza virus

Antiviral activity of garlic extract on Influenza virus

Clinical Study of the effects of Immutonic capsule in human volunteers with flu symptoms

The effects of immutonic capsule on CD4 T-Lymphocytes cells count: A case report

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