Evaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism

Tiantian, Shan; Li, Xinran; Yan, Min; Pan, Xiaowen

doi:10.2147/ijgm.s343039

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…It was found that there was significant difference in the level of D-dimer immediately after APE between the high-risk group and low-risk group (P < 0.05). The results of logistic binary regression analysis showed that D-Dimer (or = 1.95% confidence interval 1.0 ~ 1.0, P = 0.006) was one of the independent risk factors for predicting the severity of APE patients in ICU ward, which was similar to the results of previous domestic related studies [Bi 2021;Shan 2021].…”

Section: E194supporting

confidence: 86%

Analysis of the Occurrence of Acute Pulmonary Embolism in the ICU Ward and Related Risk Factors Predicting Its Severity

Chen

Zhu

et al. 2022

HSF

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Objective: To investigate the occurrence of acute pulmonary embolism in the intensive care unit (ICU) and analyze the related risk factors for predicting its severity. Methods: From January 2016 to December 2020, 83 patients with acute pulmonary embolism in the intensive care unit of Peking University People's Hospital were selected as the research subjects, including 34 males (40.96%) and 49 females (59.04%), with an average age of 62.06±16.83 years. The patients were divided into a high-risk group (N = 31), medium-risk group (N = 32), and low-risk group (N = 20), according to the guidelines for diagnosis and treatment of acute pulmonary embolism issued by ASH in 2020. The clinical characteristics, treatment, and prognosis of the three groups were summarized, and the severity of the patients could be predicted and the related risk factors affecting prognosis were analyzed. Results: There were significant statistical differences in respiratory rate, syncope as the first symptom, bilateral pulmonary embolism, and APACHE-II score among the three groups (P < 0.05). There were significant statistical differences in the laboratory indexes, such as BNP, cTnI and D-dimer before and immediately after APE among the three groups (P < 0.05). There were significant statistical differences in cTnI and D-dimer among the three groups (P < 0.05). By pairwise comparison, it was found that there were significant statistical differences between the high-risk and low-risk groups in the immediate test indexes of APE, such as BNP, D-dimer, lower extremity vascular ultrasound abnormalities, and ECG abnormalities (P < 0.05), while there was no significant statistical difference between the medium-risk and low-risk groups in the immediate test indexes of APE (P > 0.05). However, in the medium-risk group, the laboratory indexes tended to increase, in terms of treatment and outcome, thrombolysis rate, and inferior vena cava filter implantation rate. ICU stay (> 2 weeks) of the high-risk group was significantly higher than those of the other two groups, with significant statistical difference (P < 0.05). Logistic regression analysis showed that respiratory rate (or = 1.778,95% CI 1.043-3.032, P = 0.034), D-Dimer (or = 1,95% CI 1.0-1.0, P = 0.006), and APACHE-II score (or = 1.879,95% CI 1.398-2.527, P = 0.000) were independent risk factors for predicting the severity of APE patients in the ICU ward. Conclusion: Acute pulmonary embolism (APE) is a critical disease in ICU. By monitoring BNP, cTnI and D-dimer, we can identify critical patients with APE early. In addition, we found that respiratory rate, D-dimer, and APACHE-II score were independent risk factors for predicting the severity of APE patients in the ICU. Clinically, APE can be identified early. The diagnosis, treatment rate, and prognosis can be improved by monitoring these indicators.

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Section: E194supporting

confidence: 86%

Analysis of the Occurrence of Acute Pulmonary Embolism in the ICU Ward and Related Risk Factors Predicting Its Severity

Chen

Zhu

et al. 2022

HSF

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“… 17 Inflammation can lead to the high expression of hepcidin, which can lead to the inability of the body to use iron and lead to anemia. 9 The values of WBC, NE and SII in the good prognosis group were significantly lower than those in the poor prognosis group, suggesting that the inflammatory response and immune function were abnormal in tumor-related PTE patients. This may explain why the NLR and CAR in the good prognosis group of tumor-related PTE patients were significantly lower than those in the poor prognosis group, which is consistent with the results reported in the literature.…”

Section: Discussionmentioning

confidence: 83%

“…This may explain why the NLR and CAR in the good prognosis group of tumor-related PTE patients were significantly lower than those in the poor prognosis group, which is consistent with the results reported in the literature. 9 , 18–20 …”

Section: Discussionmentioning

confidence: 99%

“… 8 However, there are few reports on the prognosis of thrombotic diseases with CAR and plasma D-dimer (DD). 9 Therefore, this study retrospectively analyzed the characteristics of peripheral hematology and blood coagulation indexes in 109 patients with tumor-related PTE, so as to explore the clinical value of CAR combined with DD in predicting the prognosis and risk assessment of death in patients with tumor-related PTE.…”

Section: Introductionmentioning

confidence: 99%

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Risk Assessment of Death of Tumor-Related PTE by CAR Combined with DD Detection

Li¹,

Zheng²,

Lu³

et al. 2022

VHRM

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Objective To investigate the risk of death in patients with tumor-related PTE (pulmonary thromboembolism) detected by CAR (C-reactive protein/albumin ratio) combined with DD (D-dimer). Methods The peripheral hematology and coagulation-related indexes of 109 patients with tumor-related PTE diagnosed by PTCA were retrospectively analyzed, and the differences in relationship indexes between tumor-related PTE patients with good prognosis and poor prognosis were compared and analyzed. The receiver operating characteristic curve (ROC) was used to analyze the risk of death in patients with tumor-related PTE by CAR and DD. Results ① The values of CAR and DD in the poor prognosis group were 3.90 ± 2.69 and 21.25 ± 21.20, respectively, which were significantly higher than those in the good prognosis group (1.66 ± 1.77, 9.53 ± 3.57) ( P all <0.01). ② WBC, NE and SII in tumor-related PTE patients with poor prognosis were significantly higher than those in patients with good prognosis, while Hb in patients with poor prognosis was significantly lower than that in patients with good prognosis. ③ There was a significant positive correlation between CAR and DD ( P =0.018). ④ The values of CAR and DD in the death group were 4.07 ± 2.42 and 19.65 ± 20.48, respectively, which were significantly higher than those in the survival group (1.94 ± 2.12, 11.52 ± 15.84) ( P all<0.05). ⑤ The results of logistic regression analysis showed that both CAR ( P =0.000) and DD ( P =0.031) were independent prognostic factors in patients with tumor-related PTE. ⑥ CAR combined with DD had high sensitivity (77.8%) and specificity (83.5%), and the Youden index was 0.613. ⑦ The area under the receiver operating characteristic curve of CAR combined with DD was the largest (up to 0.806). Conclusion CAR and DD were highly expressed in patients with poor prognosis of tumor-related PTE. CAR combined with DD detection is helpful to improve the correct assessment of the risk of death in patients with tumor-related PTE.

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“…It can be determined in a cheap and easily available way. Recent studies showed an increase in the blood level of neutrophils in patients with PTE [9,10]. Also, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride (TG) are found to be associated with the incidence and prognosis of venous thromboembolism (VTE) and PTE [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Lipid-to-neutrophil ratios in predicting in-hospital outcomes in pulmonary thromboembolism

Roshanravan,

Hamzehzadeh,

Ghaffari

et al. 2024

Preprint

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Objective Acute pulmonary thromboembolism (PTE) is one of the leading causes of death and severe disability. Considering the availability and accessibility of complete blood count (CBC) and lipid profiles, our study was conducted to assess the predictive value of lipid-to-neutrophil count ratios for the short-term survival of PTE patients. Results The population of this analytical cross-sectional study consists of 547 PTE patients of which 41 patients (7.5%) died during hospitalization. There was a significant difference between death and survived groups regarding cholesterol (146.00[60.50] vs. 165.50[59.75]; p-value < 0.01), LDL (80.00[48.00] vs. 102.00[52.00]; p-value < 0.01), HDL (31.00[19.00] vs. 35.00[14.00]; p-value = 0.04). Cholesterol/neutrophil*1000 with a cut-off value of 22.014 (sensitivity: 56.7%; specificity: 61.3%), LDL/neutrophil*1000 with a cut-off value of 10.909 (sensitivity: 69.3%; specificity: 51.9%) and HDL/neutrophile *1000 with a cut-off value of 4.150 (sensitivity: 61.9%; specificity: 58.1%) can predict short-term survival in patients with acute PTE. Based on our findings, patients with higher cholesterol/neutrophil, LDL/neutrophil, and HDL/neutrophil ratios have a better in-hospital prognosis and measurement of lipid-to-neutrophil ratio in the first 24 hours of hospitalization may be a valuable marker for determining the early prognosis of PTE.

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Evaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism

Cited by 4 publications

References 14 publications

Analysis of the Occurrence of Acute Pulmonary Embolism in the ICU Ward and Related Risk Factors Predicting Its Severity

Analysis of the Occurrence of Acute Pulmonary Embolism in the ICU Ward and Related Risk Factors Predicting Its Severity

Risk Assessment of Death of Tumor-Related PTE by CAR Combined with DD Detection

Lipid-to-neutrophil ratios in predicting in-hospital outcomes in pulmonary thromboembolism

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